Research theme for competitive and other funds (11):
2023 - 2028 Elucidation of mechanisms and functions of the postnatal neutrophil surge
2022 - 2025 転写因子TFEBの分解誘導機構の理解に基づく血管石灰化治療の検討
2021 - 2022 Examination on TFEB-targeted therapy for vascular calcification
2021 - 2022 Elucidation of the Lysosome Dysfunction that leads to vascular calcification in CKD
2019 - 2022 Prostaglandin E3-oriented regulation of chronic inflammation
2019 - 2021 The roles of Prostaglandin E3 in the development of atherosclerosis
2020 - 2021 平滑筋ライソゾームを標的とした血管石灰化治療
2019 - 2021 Treatment of vascular calcification by lysosome activation
2019 - 2020 The preventive effects of Prostaglandin E3, a ω3-derived mediator, on atherosclerosis
2019 - 2020 The roles of umbilical cord-derived G-CSF
2014 - 2017 Inhibition of PGE2-EP4 signaling as a therapeutic strategy for abdominal aortic aneurysm
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Papers (19):
Ryo Ishiwata, Yuji Morimoto. Hyperphosphatemia-induced degradation of transcription factor EB exacerbates vascular calcification. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2022. 1868. 3. 166323-166323
Taro Hiromi, Utako Yokoyama, Daisuke Kurotaki, Al Mamun, Ryo Ishiwata, Yasuhiro Ichikawa, Hiroshi Nishihara, Masanari Umemura, Takayuki Fujita, Shota Yasuda, et al. Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation. Arteriosclerosis, thrombosis, and vascular biology. 2020. 40. 6. ATVBAHA120314297-1573
Yokoyama U, Arakawa N, Ishiwata R, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Matsumoto M, Koizumi N, et al. Proteomic analysis of aortic smooth muscle cell secretions reveals an association of myosin heavy chain 11 with abdominal aortic aneurysm. American journal of physiology. Heart and circulatory physiology. 2018. 315. 4. H1012-H1018
Mechanisms of the Postnatal Neutrophil Surge and its Potential Roles in the Establishment of Postnatal Homeostasis.
(The 101st Annual Meeting of The Physiological Society of Japan 2024)
Hepatic neutrophil pool possibly contributes to the postnatal neutrophil surge
(The 100th Anniversary Annual Meeting of The Physiological Society of Japan 2023)
高リン酸血症による転写因子TFEBの 分解促進は血管石灰化を促す
(筋生理の集い 2022)
Transcription Factor EB Regulates Hyperphosphatemia-induced Vascular Calcification
(the 98th Annual Meeting of The Physiological Society of Japan 2021)
Inhibition of PGE2-EP4 Signaling as a Potential Future Therapeutic Strategy for Abdominal Aortic Aneurysm
(2016)