MOROISHI Toshiro

モロイシトシロウ | MOROISHI Toshiro

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Institute of Science Tokyo Department of Cellular Dynamics Professor

Homepage URL (1)： https://moroishi-lab.com

Research field (5)： Developmental biology , Medical biochemistry , Molecular biology , Cell biology , Tumor biology

Research keywords (5)： Iron metabolism , Signal transduction , Cell-cell communication , Cancer , Development

Research theme for competitive and other funds (15)：

2024 - 2031 Towards the understanding of cellular community maintained by cell competition and symbiosis
2023 - 2029 DNAイベントレコーダー細胞
2024 - 2027 「適応多様性」研究領域の拡大・発展に向けた総括研究
2024 - 2027 哺乳類の器官形成における「適応多様性」の解明
2023 - 2026 胎児丸ごとの体外培養法を用いた次世代オルガノイドの開発

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Papers (48)：

Tomoya Yamashita, Haruki Horiguchi, Tsuyoshi Kadomatsu, Michio Sato, Toshiro Moroishi, Yuichi Oike. Immunotherapy-induced reprogramming of cancer-associated fibroblasts can promote tumor progression. Genes to cells : devoted to molecular & cellular mechanisms. 2024
Chanida Thinyakul, Yasuhisa Sakamoto, Mayuko Shimoda, Yanliang Liu, Suyanee Thongchot, Omnia Reda, Akihiro Nita, Romgase Sakamula, Somponnat Sampattavanich, Ayato Maeda, et al. Hippo pathway in cancer cells induces NCAM1+αSMA+ fibroblasts to modulate tumor microenvironment. Communications Biology. 2024. 7. 1. 1343
Yasuhisa Sakamoto, Akiyoshi Uezu, Koji Kikuchi, Jangmi Kang, Eiko Fujii, Toshiro Moroishi, Shiro Suetsugu, Hiroyuki Nakanishi. The Nedd4L ubiquitin ligase is activated by FCHO2-generated membrane curvature. The EMBO Journal. 2024
Shinsei Yumoto, Haruki Horiguchi, Tsuyoshi Kadomatsu, Taichi Horino, Michio Sato, Kazutoyo Terada, Keishi Miyata, Toshiro Moroishi, Hideo Baba, Yuichi Oike. Host ANGPTL2 establishes an immunosuppressive tumor microenvironment and resistance to immune checkpoint therapy. Cancer science. 2024
Hao Li, Yohei Kanamori, Toshiro Moroishi. Cell attachment defines sensitivity to cold stress via the Hippo pathway. Biochemical and Biophysical Research Communications. 2024. 730. 150373-150373

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MISC (14)：

前田英仁, 諸石寿朗. Hippo経路. がんゲノムペディア. 2024. 71-73
諸石寿朗. ラボ百景:多様なバックグラウンドをもった仲間と多様性の研究を楽しむ. 実験医学. 2023. 41. 13. 2186-2188
金森耀平, 諸石寿朗. 鉄動態の制御と肝癌の進行. 肝胆膵. 2022. 84. 4. 491-496
仁田暁大, 諸石寿朗. 腫瘍免疫の制御における細胞外小胞の二面性-細胞外小胞を利用したがん治療法の開発へ向けて. 実験医学. 2021. 39. 20. 3189-3195
竹島裕貴, 諸石寿朗. Hippo細胞内シグナル伝達経路による組織恒常性の維持機構. 臨床免疫・アレルギー科. 2021. 76. 2. 182-189

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Education (2)：

2008 - 2012 Kyushu University Graduate School of Medical Sciences
2002 - 2008 Kyushu University Faculty of Medicine

Professional career (1)：

M.D., Ph.D. (Kyushu University)

Work history (5)：

2024/09 - 現在 Institute of Science Tokyo Medical Research Institute Professor
2020/01 - 現在 Kumamoto University Faculty of Life Sciences Professor
2017/12 - 2019/12 Kumamoto University Faculty of Life Sciences Associate Professor
2013/04 - 2017/08 University of California, San Diego, Department of Pharmacology and Moores Cancer Center, Postdoctoral fellow
2012/04 - 2013/03 Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan Postdoctoral fellow

Committee career (2)：

2023/04 - 現在 The Japanese Biochemical Society Councilor
2020/04 - 現在 Communications Biology (Springer Nature) Editorial Board Member

Awards (3)：

2021/04 - Ministry of Education, Culture, Sports, Science and Technology (MEXT) 科学技術分野の文部科学大臣表彰若手科学者賞(令和3年度) シグナル伝達と代謝調節による生体恒常性維持機構の研究
2019/06 - The Kao Foundation for Arts and Sciences 花王科学奨励賞(平成31年度) 組織修復・再生を担うHippoシグナルの全貌解明
2013/02 - Inoue Foundation for Science Inoue Research Award for Young Scientists (29th) ユビキチン化による鉄代謝制御の中心をなすFBXL5-IRP2系の発見

Association Membership(s) (6)：

The Japanese BioIron Society , The Japanese Pharmacological Society , The Japanese Cancer Association , Japanese Association of Cancer Immunology , The Molecular Biology Society of Japan , The Japanese Biochemical Society

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