TOSHIYUKI KUDO

クドウトシユキ | TOSHIYUKI KUDO

Affiliation and department：

Research field (1)： Clinical pharmacy

Research keywords (1)：薬物動態・代謝学

Research theme for competitive and other funds (8)：

2022 - 2025 a
2018 - 2022 Pharmacokinetics and pharmaceutics investigation on copper complex to development an oral therapeutic agent for Menkes disease.
2018 - 2022 薬物相互作用のモデル解析のためのin vivo酵素阻害パラメータ推定方法の確立
2019 - 2022 薬物相互作用・生理機能変化を踏まえた医薬品の投与最適化の評価・予測手法の開発
2016 - 2018 メトロニダゾールによる薬物相互作用機構の解明および新たな相互作用の可能性の検討

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Papers (68)：

Kenjiro Okubo, Toshiyuki Kudo, Sae Yoshihara, Yu Nakabayashi, Kana Nakauchi, Akimi Tanaka, Moe Saito, Ayumi Tsujisawa, Hitomi Goda, Yoshiaki Yamagishi, et al. Physiologically based pharmacokinetic model analysis of the inhibitory effect of vonoprazan on the metabolic activation of proguanil. Drug Metabolism and Pharmacokinetics. 2024. 54. 100537-100537
Tomohisa Nakada, Toshiyuki Kudo, Kiyomi Ito. Quantitative Consideration of Clinical Increases in Serum Creatinine Caused by Renal Transporter Inhibition. Drug metabolism and disposition: the biological fate of chemicals. 2023
Toshiyuki Hikita, Hitomi Goda, Yasuko Ogawa, Toshiyuki Kudo, Kiyomi Ito. Caffeine consumption as a risk factor for childhood and adolescence migraine. Pediatrics international : official journal of the Japan Pediatric Society. 2023. 65. 1. e15429
川野久美, 工藤敏之, 前田和哉, 嶋田努, 水野尚美. フォーカスグループのこれまでの軌跡と今後の展望薬物相互作用・個別化医療FG. 薬剤学: 生命とくすり. 2022. 82. 3. 121-125
Kentaro Ohta, Nobuko Matsushima, Hiromi Tanii, Herta Crauwels, Toshiyuki Kudo, Kiyomi Ito. Pharmacokinetics and safety of rilpivirine in healthy Japanese subjects and exploration of ethnic sensitivity of rilpivirine pharmacokinetics with physiologically based pharmacokinetic model approach. Drug metabolism and pharmacokinetics. 2021. 41. 100422-100422

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MISC (13)：

舟越亮寛, 友田有加菜, 工藤敏之, 牧野宏章, 高橋秀依, 楠原洋之, 降旗謙一, 伊藤清美. vonoprazanおよびesomeprazoleとproguanilとの臨床相互作用試験. 臨床薬理. 2018. 49. Supplement
Toshiyuki Kudo, Yuya Ozaki, Eri Hotta, Aya Matsubara, Kiyomi Ito. EFFECT OF BUFFER CONDITIONS ON CYP2C8-MEDIATED 6 alpha-HYDROXYLATION OF PACLITAXEL BY HUMAN LIVER MICROSOMES. DRUG METABOLISM REVIEWS. 2015. 47. 193-194
Toshiyuki Kudo, Akihiro Hisaka, Yuchi Sugiyama, Kiyomi Ito. Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes. FASEB JOURNAL. 2014. 28. 1
Toshiyuki Kudo, Akihiro Hisaka, Yuichi Sugiyama, Kiyomi Ito. ANALYSIS OF THE GLIBENCLAMIDE CONCENTRATION INCREASE BY CLARITHROMYCIN BASED ON THE INHIBITION OF HEPATIC UPTAKE TRANSPORTER AND METABOLIC ENZYMES USING A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL. DRUG METABOLISM REVIEWS. 2012. 44. 73-74
工藤敏之, 五十嵐伊織, 阿部里絵子, 吉澤麻理子, 戸田雄大, 嶋田努, 鈴木亘, 五十嵐信智, 伊藤清美, 油田正樹, et al. 20-P3-470 肥満型糖尿病モデルTSODマウスの肝臓における薬物トランスポーターの発現変動(薬物動態(基礎),来るべき時代への道を拓く). 日本医療薬学会年会講演要旨集. 2008. 18. 357-357

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Books (7)：

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Lectures and oral presentations (142)：

チアミンの経細胞輸送に及ぼすメトロニダゾールの影響
(日本薬学会第143年会 2023)
弱いCYP3A4阻害薬を複数併用した際の基質薬血中濃度変化の予測
(日本薬学会第143年会 2023)
メンケス病モデル動物の脳組織における銅依存性酵素活性の評価
(第32回日本医療薬学会年会 2022)
フルニトラゼパム代謝におけるCYP3A4の寄与率の推定
(医療薬学フォーラム2022 第22回クリニカルファーマシーシンポジウム 2022)
Caco-2細胞におけるチアミン-d3の経細胞輸送に及ぼすメトロニダゾールの影響
(日本医療薬学会第5回フレッシャーズ・カンファランス 2022)

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Education (4)：

Professional career (3)：

Work history (4)：

2015/04/01 - 現在 Musashino University Faculty of Pharmacy, Department of Pharmaceutical Sciences
2010/04/01 - 2015/03/31 Musashino University Faculty of Pharmacy, Department of Pharmaceutical Sciences
2010/04 - 2015/03 Assistant Professor
2010/04 - 2015/03 Assistant Professor

Committee career (2)：

Awards (2)：

2014/01 - Drug Metabolism Division of ASPET James R. Gillette Drug Metabolism Best Paper of 2013 Analysis of the Repaglinide Concentration Increase Produced by Gemfibrozil and Itraconazole Based on the Inhibition of the Hepatic Uptake Transporter and Metabolic Enzymes
2007/09 - 第24回和漢医薬学会大会優秀発表賞受賞

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