Denda Masaya

デンダマサヤ | Denda Masaya

Affiliation and department：
Job title：助教
Homepage URL (1)： https://www.tokushima-u.ac.jp/ph/faculty/labo/syn/otaka/

Research field (2)： Clinical pharmacy , Pharmaceuticals - chemistry and drug development

Research keywords (9)：創薬科学 , ペプチド・タンパク質化学 , 抗薬物抗体 , タンパク質ラベル化 , ケミカルバイオロジー , 関節リウマチ , 薬物体内動態 , 医療薬剤学 , 薬学

Research theme for competitive and other funds (4)：

2024 - 2027 相互作用タンパク質の同定・トポロジー解析を指向した光活性型クロスリンカーの開発
2022 - 2024 ペプチド環化反応をトリガーとした抗がん剤新規放出システム搭載型ADCの創出研究
2019 - 2020 TDM解析を基盤とした、リウマチ治療における生物学的製剤適正使用法の確立研究
2013 - 2016 タンパク質機能解明を指向した新規タンパク質選択的ラベル化法の開拓

Papers (52)：

Kota Hidaka, Daishiro Kobayashi, Junya Hayashi, Masaya Denda, Akira Otaka. Cover Feature: Advanced Insulin Synthesis by One-pot/Stepwise Disulfide Bond Formation Enabled by S-Protected Cysteine Sulfoxide (Chem. Eur. J. 39/2024). Chemistry - A European Journal. 2024
Kota Hidaka, Daishiro Kobayashi, Junya Hayashi, Masaya Denda, Akira Otaka. Advanced Insulin Synthesis by One-pot/Stepwise Disulfide Bond Formation Enabled by S-Protected Cysteine Sulfoxide. Chemistry - A European Journal. 2024
Junya Hayashi, Daishiro Kobayashi, Masaya Denda, Akira Otaka. Late-Stage Formation of a Sactionine Linkage Enabled by Lossen Rearrangement of Glycyl Hydroxamic Acid. Organic Letters. 2024
Junya Hayashi, Daishiro Kobayashi, Chizuru Namikawa, Masaya Denda, Akira Otaka. Synthesis of N-Glyoxylyl Peptides Enabled by a Lossen Rearrangement-Induced Intramolecular Redox Reaction of N-Terminal Glycyl Hydroxamic Acid. Organic Letters. 2024
Daishiro Kobayashi, Masaya Denda, Junya Hayashi, Kota Hidaka, Yutaka Kohmura, Takaaki Tsunematsu, Kohei Nishino, Harunori Yoshikawa, Kento Ohkawachi, Kiyomi Nigorikawa, et al. Sulfoxide-Mediated Cys-Trp-Selective Bioconjugation that Enables Protein Labeling and Peptide Heterodimerization. ChemistryEurope. 2024

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MISC (28)：

左東大輝, 常松保乃加, 上田智子, 小宮千明, 傳田将也, 重永章, 大高章. Convenient synthesis of cyclic depsipeptides using peptide thioesters. 日本薬学会年会要旨集(Web). 2021. 141st
小林大志朗, 光村豊, 倉岡瑛祐, 傳田将也, 大高章. Development of the thioether-forming reaction between Cys and Trp using S-protected cysteine sulfoxide. 日本薬学会年会要旨集(Web). 2021. 141st
安崎快登, 大川内健人, 小林大志朗, 喜屋武龍二, 傳田将也, 重永章, 大高章. 保護Cysスルホキシドを利用したS-Aryl化環状ペプチド合成研究. 創薬懇話会講演要旨集. 2021. 2021
光村豊, 小林大志朗, 杉木俊彦, 吉丸哲郎, 倉岡瑛祐, 傳田将也, 藤原敏道, 片桐豊雅, 大高章. Cys-Trp架橋型乳がん抑制ペプチド(ERAP)の合成及び活性評価. 創薬懇話会講演要旨集. 2021. 2021
傳田将也, 小宮千明, 上田将弘, 月本準, 伊藤孝司, 重永章, 大高章. Protein modification via the thioester-generating methodology utilizing enzymatic and chemical reactions. 日本薬剤学会年会講演要旨集(CD-ROM). 2021. 36th

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Lectures and oral presentations (14)：

既存モダリティの高度化を指向したペプチド・タンパク質新規修飾法の開発
(日本薬剤学会第36年会 2021)
Development of a Protection-free Protocol for the Synthesis of Lactone Peptides
(The 57 th Japanese Peptide Symposium (online) 2020)
Deprotection of S-Acetamidomethyl Cysteine mediated by Copper Salts
(The 57 th Japanese Peptide Symposium (online) 2020)
A NEW THIOL ADDITIVE FOR ONEPOT SEQUENTIAL PEPTIDE LIGATION-DESULFURIZATION CHEMISTRY
(The 57 th Japanese Peptide Symposium (online) 2020)
Measurement of infliximab and anti-drug antibody levels in patients with inflammatory bowel disease
(78th FIP World Congress of Pharmacy and Pharmaceutical Sciences 2018)

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Education (3)：

2013 - 2016 The University of Tokushima Graduate School of Pharmaceutical Sciences
2011 - 2013 The University of Tokushima Graduate School of Pharmaceutical Sciences
2007 - 2011 The University of Tokushima Faculty of Pharmaceutical Sciences School of Pharmaceutical Technosciences

Professional career (1)：

博士(薬科学) (徳島大学)

Work history (3)：

2017/07 - 2020/03 Kyoto University Graduate School of Pharmaceutical Sciences
2016/10 - 2017/06 Kyoto University Pharmacy, Hospital
2013/04 - 2016/03 日本学術振興会特別研究員(DC1)

Awards (2)：

2015 - 日本ペプチド学会 JPS Travel Award 2015
2012/06 - 日本ケミカルバイオロジー学会第7回ポスター賞新規タンパク質選択的ラベル化試薬“SEAL-tag”の開発研究

Association Membership(s) (7)：

Japanese Society for Chemical Biology , The Japanese Peptide Society , JAPANESE SOCIETY OF PHARMACEUTICAL HEALTH CARE AND SCIENCES , 日本病院薬剤師会 , 日本薬剤師会 , THE PHARMACEUTICAL SOCIETY OF JAPAN , 日本薬学教育学会

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