Takahiro Nakayama

ナカヤマタカヒロ | Takahiro Nakayama

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： https://ridb.kanazawa-u.ac.jp/public/detail.php?id=4087 , https://ridb.kanazawa-u.ac.jp/public/detail_en.php?id=4087

Research field (2)： Molecular biology , Biophysics

Research keywords (1)： Single molecule observation, Cell biophysics, Atomic force microscopy

Research theme for competitive and other funds (13)：

2023 - 2026 Supramolecular behavior and dynamic capture of meta-aggregates
2023 - 2026 Universalization of high-speed atomic force microscopy targets
2023 - 2026 Investigation of relationship between structural variety and function of tumor suppressor protein, p53
2020 - 2021 がん抑制因子p53の凝集の立体構造動態と機能の解明
2017 - 2021 Study on transmission of Abeta aggregates and its prevention

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Papers (54)：

Kazutaka Araki, Takahiro Watanabe-Nakayama, Daisuke Sasaki, Yuji C. Sasaki, Kazuhiro Mio. Molecular Dynamics Mappings of the CCT/TRiC Complex-Mediated Protein Folding Cycle Using Diffracted X-ray Tracking. International Journal of Molecular Sciences. 2023. 24. 19. 14850-14850
Tomoko Hirano, Kazuo Ebine, Takashi Ueda, Takumi Higaki, Takahiro Watanabe-Nakayama, Hiroki Konno, Hisako Takigawa-Imamura, Masa H Sato. The SYP123-VAMP727 SNARE complex delivers secondary cell wall components for root hair shank hardening in Arabidopsis. The Plant Cell. 2023. 35. 12. 4347-4365
Takahiro Watanabe-Nakayama, Mayumi Tsuji, Kenichi Umeda, Tatsunori Oguchi, Hiroki Konno, Moeko Noguchi-Shinohara, Yuji Kiuchi, Noriyuki Kodera, David B. Teplow, Kenjiro Ono. Structural Dynamics of Amyloid-β Protofibrils and Actions of Anti-Amyloid-β Antibodies as Observed by High-Speed Atomic Force Microscopy. Nano Letters. 2023
紺野宏記, 中山隆宏, 安藤敏夫, 田口英樹. Single-molecule High-speed AFM Observation of Fiber Elongation of Prion Protein Sup35. 生物物理(Web). 2022. 62. 6. 327-330
Takahiro Watanabe-Nakayama, Kenjiro Ono. Single-molecule observation of self-propagating amyloid fibrils. Microscopy. 2022

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MISC (44)：

小野賢二郎, 中山隆宏, 辻まゆみ, 梅田健一, 小口達敬, 紺野宏記, 篠原もえ子, 木内祐二, 古寺哲幸, Teplow David B. 高速原子間力顕微鏡を用いたAβプロトフィブリルの構造動態とレカネマブの作用. Dementia Japan. 2023. 37. 4. 677-677
中野博人, 浜口毅, 池田篤平, 中山隆宏, 小野賢二郎, 山田正仁. Effects of inactivation procedures for seeding activity of amyloid β-protein aggregates(タイトル和訳中). 神経治療学. 2023. 40. 6. S275-S275
中山隆宏. High-speed atomic force microscopy reveals structural dynamics of amyloid aggregation. 実験医学. 2023. 41. 12. 1899-1906
中野博人, 浜口毅, 池田篤平, 中山隆宏, 小野賢二郎, 山田正仁. アミロイドβ凝集体におけるシーディング活性の不活化に関するin vitro研究. 日本脳血管・認知症学会総会プログラム・抄録集. 2023. 13th
Lim Keesiang, 西出梧朗, 中山隆宏, 華山力成, 安藤敏夫, Wong Richard W. SARS-CoV-2スパイクタンパク質の構造ダイナミクスとACE2受容体および小さな細胞外小胞との相互作用のミリ秒追跡。. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 1P-373

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Books (3)：

いま新薬で加速する神経変性疾患研究 : 異常タンパク質の構造、凝集のしくみから根本治療の真の標的に迫る
羊土社 2023 ISBN:9784758104128
Cells, Forces, and the Microenvironment
CRC Press 2015 ISBN:9789814613361
Atomic force microscopy in liquid : biological applications
Wiley-VCH 2012 ISBN:9783527327584

Lectures and oral presentations (14)：

アミロイド凝集構造動態の単分子ビデオイメージング
(第64回日本神経病理学会総会学術研究会・第66回日本神経化学会大会合同大会 2023)
Single molecule observation of structural dynamics in the prion-like structural replication reaction of amyloid fibrils
(The Molecular Biology Society of Japan 2022)
高速原子間力顕微鏡による医学薬学研究への展開-アミロイド凝集過程とその抑制因子の作用機序の解明を目指して-
(単一生体分子の動的プロセス評価に向けた高速AFM技術 2020)
Do the individual amyloid aggregates follow the prion model?
(International Symposium on Pathomechanism of Amyloid Diseases 2019)
「高速原子間力顕微鏡の医学・薬学分野への展開と応用」 (アミロイド凝集過程と制御機構の解明方法)
(MS-NEX発売記念セミナー(株式会社生体分子計測研究所) 2019)

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Education (3)：

2005 - 2008 Tokyo Institute of Technology Interdisciplinary Graduate School of Science and Engineering Department of Electronic Chemistry
2001 - 2003 Hiroshima University Graduate School of Science Department of Biological Science
1997 - 2001 Hiroshima University Faculty of Education

Professional career (1)：

Work history (6)：

2017/10 - 現在 Nano Life Science Institute, Kanazawa University Associate Professor
2017/04 - 2017/09 Bio-AFM Frontier Research Center, Kanazawa University Associate Professor
2012/04 - 2017/03 Bio-AFM Frontier Research Center, Kanazawa University Assistant Professor
2008/04/01 - 2012/03/31 Tokyo Institute of Technology Postdoctoral Researcher
2004/04/01 - 2005/03/01 Japan Science and Technology Agency

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Association Membership(s) (3)：

Biophysical Society , 日本生物物理学会 , 日本分子生物学会

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