Research theme for competitive and other funds (8)：
2023 - 2026 miRNA生合成阻害因子によるNASH発症・増悪化の新たな調節機構の解明
2018 - 2023 Preservation of mammalian genetic resources and study for the developmental mechanism using freeze-dried cells
2019 - 2022 The effect of RNA binding proteins on regulatory mechanisms of anti-fibrotic and anti-inflammatory miRNA biogenesis
2020 - 2021 RNA修飾によるがん抑制miRNA産生性制御機構の解明
2016 - 2019 Elucidation of molecular mechanisms through RNA-RNA binding protein network in physiological regulation and disease onset
2017 - 2019 複数のマイクロRNA産生制御を介した新規癌治療法の開発を目指した基礎研究
2013 - 2016 A novel RNA metabolism involved in cell differentiation and survival
2012 - 2015 癌抑制マイクロRNA調節因子による癌化メカニズムの解明
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Papers (17)：
Ken-ichi MATSUMOTO, Takuma HIGUCHI, Mirei UMEKI, Masafumi ONO, Shuji SAKAMOTO. Tenascin-X is increased with decreased expression of miR-378a-5p and miR-486-5p in mice fed a methionine-choline-deficient diet that induces hepatic fibrosis. Biomedical Research. 2024. 45. 2. 67-76
Sylvia Lai, Takuma Higuchi, Masayuki Tsuda, Yasunori Sugiyama, Keiko Morisawa, Taketoshi Taniguchi, Shuji Sakamoto. NF90-NF45 is essential for β cell compensation under obesity-inducing metabolic stress through suppression of p53 signaling pathway. Scientific reports. 2022. 12. 1. 8837-8837
Kaz Kawamura, Takuma Higuchi, Shigeki Fujiwara. YAF2-Mediated YY1-Sirtuin6 Interactions Responsible for Mitochondrial Downregulation in Aging Tunicates. Molecular and Cellular Biology. 2021. 41. 7
Takuma Higuchi, Rosemary Kiernan, Shuji Sakamoto. Characteristic analysis of a secondary structure of primary microRNA bound to a double-strand RNA-binding protein, NF90. Electrophoresis Letters. 2021. 65. 1. 13-16
Giuseppa Grasso, Takuma Higuchi, Victor Mac, Jérôme Barbier, Marion Helsmoortel, Claudio Lorenzi, Gabriel Sanchez, Maxime Bello, William Ritchie, Shuji Sakamoto, et al. NF90 modulates processing of a subset of human pri-miRNAs. Nucleic acids research. 2020
