Ryo Kamata

カマタリョウ | Ryo Kamata

Affiliation and department：
Homepage URL (1)： https://nrid.nii.ac.jp/nrid/1000060801420/

Research field (2)： Tumor diagnostics and therapeutics , Molecular biology

Research keywords (4)：染色体不安定性 , 染色体分配 , 自然免疫応答 , 細胞老化

Research theme for competitive and other funds (7)：

2023 - 2026 新規CENP-E阻害剤による染色体不安定性を介した自然免疫惹起機構の解明
2023 - 2024 Elucidation of the mechanism of immune response mediated by chromosomal instability and establishment of immune checkpoint inhibitor combination therapy
2021 - 2023 Leading edgeのGTP代謝コンパートメントによる新規細胞遊走制御の解明
2022 - 2023 SA-T
2019 - 2021 Elucidation of the mechanism of NLRP3 inflammasome regulation by ARIH2

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Papers (26)：

Tomoko Yamamori Morita, Jie Yu, Yukie Kashima, Ryo Kamata, Gaku Yamamoto, Tatsunori Minamide, Chiaki Mashima, Miyuki Yoshiya, Yuta Sakae, Toyohiro Yamauchi, et al. CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade. Nature Communications. 2023. 14. 1
Kazuki Nakai, Hancheng Lin, Shotaro Yamano, Shinya Tanaka, Sho Kitamoto, Hitoshi Saitoh, Kenta Sakuma, Junpei Kurauchi, Eilma Akter, Masamitsu Konno, et al. Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway. Nature Communications. 2023. 14. 1
R. Kamata, Y. Hakozaki, Y. Kashima, T.Y. Morita, P. Lu, A. Ohashi. CENP-E inhibitor potently activates cGAS-STING pathway through misaligned chromosome-mediated micronucleation after mitotic slippage. European Journal of Cancer. 2022. 174. S47-S48
Yoshiki Ikeda, Akiyoshi Hirayama, Satoshi Kofuji, Yoshihisa Hirota, Ryo Kamata, Natsuki Osaka, Yuki Fujii, Mika Sasaki, Satsuki Ikeda, Eric P Smith, et al. SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides. Journal of biochemistry. 2021. 170. 6. 699-711
Natsuki Osaka, Yoshihisa Hirota, Doshun Ito, Yoshiki Ikeda, Ryo Kamata, Yuki Fujii, Venkat R Chirasani, Sharon L Campbell, Koh Takeuchi, Toshiya Senda, et al. Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification. Frontiers in molecular biosciences. 2021. 8. 707439-707439

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MISC (22)：

Pinyi Lu, Ryo Kamata, Michael R. Weil, Naomi Ohashi, Akihiro Ohashi, Eric A. Stahlberg. Abstract 4945: Computational modeling-based discovery of novel anticancer drug candidates targeting centromere-associated protein E. Cancer Research. 2024. 84. 6_Supplement. 4945-4945
Ryo Kamata, Hitoshi Saito, Yumi Hakozaki, Yukie Kashima, Gaku Yamamoto, Tomoko Yamamori Morita, Pinyi Lu, Akihiro Ohashi. Abstract 411: PI3K-AKT-mTOR signaling pathways play important roles in chromosomal instability-induced innate immune response in cancer cells. Cancer Research. 2024. 84. 6_Supplement. 411-411
Gaku Yamamoto, Kosuke Tanaka, Ryo Kamata, Takehiro Nakao, Shunta Mori, Jie Liu, Susumu S. Kobayashi, Akihiro Ohashi. Abstract 1938: WEE1 inhibition prevents and overcomes resistance to KRAS inhibitors in lung cancer by enhancing MCL1-mediated apoptosis. Cancer Research. 2024. 84. 6_Supplement. 1938-1938
Hiroki Yamashita, Jason Guoqiang Zhang, Chiaki Mashima, Ryo Kamata, Tomoko Yamamori, Izuma Nakayama, Akihito Kawazoe, Kohei Shitara, Tomonori Yano, Qunli Xu, et al. Abstract 5075: Transcriptomic landscape of tumor microenvironment in gastric cancer in treatment with different types of cancer drugs. Cancer Research. 2024. 84. 6_Supplement. 5075-5075
Ryo Kamata, Toyohiro Yamauchi, Yuta Sakae, Ross Breckenridge, Martin Treder, Akihiro Ohashi. Abstract B148: Novel low-atomic cluster Ag5 induced oxidative stress and antiproliferation in Esophageal Squamous Cell Carcinoma Cells. Molecular Cancer Therapeutics. 2023. 22. 12_Supplement. B148-B148

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Lectures and oral presentations (22)：

新規イオンクラスターAg5による細胞内代謝変動と細胞死誘導メカニズムの解明
(6NCリトリート-医療ビッグデータ・医療DX- 2024)
Mechanistic analysis of a novel germline mutation in the BRCA2 untranslated region
(2023mbsj 2023)
CENP-E inhibitors activate the cGAS-STING pathway by inducing micronucleus formation after chromosome missegregation
(2023)
Novel low-atomic cluster Ag5 induced oxidative stress and cell death in esophageal squamous cell carcinoma cells
(2023mbsj 2023)
Novel Low-Atomic Cluster Ag5 Induced Oxidative Stress And Antiproliferation In Esophageal Squamous Cell Carcinoma Cells
(the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics 2023)

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Education (2)：

2013 - 2017 Hiroshima University Graduate School of Biomedical Sciences
2007 - 2013 Nihon Pharmaceutical University

Professional career (1)：

博士(医学) (広島大学)

Work history (5)：

2023/04 - 現在 National Cancer Center
2022/03 - 2023/03 National Cancer Center
2020/08 - 2022/03 Jichi Medical University School of Medicine
2020/08 - 2022/02 Keio University
2017/04 - 2020/07 Jichi Medical University School of Medicine

Awards (1)：

2016/10 - 日本脈管学会 Japanese College of Angiology Award 最優秀賞

Association Membership(s) (3)：

日本癌学会 , 日本がん分子標的治療学会 , 日本分子生物学会

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