Nakao Hiroyuki

ナカオヒロユキ | Nakao Hiroyuki

Affiliation and department：
Job title：助教

Research field (3)： Nanobioscience , Pharmaceuticals - analytical and physicochemistry , Biophysics

Research keywords (7)： liposome , phospholipid , neutron scattering , fluorescence , membrane-spanning peptide , lipid scrambling , flip-flop

Research theme for competitive and other funds (11)：

2023 - 2026 人工的なPS露出によるeat-meシグナルは免疫チェックポイントを上回るか
2022 - 2026 Development of Molecules Inducing Disruption of Cell Membrane Asymmetry and Search for Endoplasmic Reticulum Lipid Scrambling Factors
2023 - 2024 がん細胞貪食を誘導するフリップフロップ促進ペプチドの開発
2023 - 2024 細胞膜フリップフロップ促進ペプチドによる細胞貪食誘導
2020 - 2023 脂質-ペプチドナノ粒子を用いた標的細胞膜への膜タンパク質デリバリー技術の開発

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Papers (24)：

Keisuke Ikeda, Yuuki Sugiura, Hiroyuki Nakao, Minoru Nakano. Thermodynamics of oligomerization and Helix-to-sheet structural transition of amyloid β-protein on anionic phospholipid vesicles. Biophysical chemistry. 2024. 310. 107248-107248
Hiroyuki Nakao, Michihiro Nagao, Takeshi Yamada, Koki Imamura, Koichi Nozaki, Keisuke Ikeda, Minoru Nakano. Impact of transmembrane peptides on individual lipid motions and collective dynamics of lipid bilayers. Colloids and Surfaces B: Biointerfaces. 2023. 228. 113396-113396
Motomi Matsuda, Keisuke Ikeda, Tomoshi Kameda, Hiroyuki Nakao, Minoru Nakano. Fine-Tuning and Enhancement of pH-Dependent Membrane Permeation of Cyclic Peptides by Utilizing Noncanonical Amino Acids with Extended Side Chains. Journal of Medicinal Chemistry. 2023. 66. 10. 7054-7062
Chinatsu Shimizu, Keisuke Ikeda, Hiroyuki Nakao, Minoru Nakano. Amphipathic peptide-phospholipid nanofibers: Kinetics of fiber formation and molecular transfer between assemblies. Biophysical Chemistry. 2023. 296. 106985-106985
Ayari Miyajima, Hiroyuki Nakao, Keisuke Ikeda, Minoru Nakano. The Nanometer-Scale Proximity of Bilayers Facilitates Intermembrane Lipid Transfer. The Journal of Physical Chemistry Letters. 2023. 14. 18. 4172-4178

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MISC (43)：

Nakao Hiroyuki. Development of Phospholipid Flip-flop Promoting Peptides and Regulation of Cellular Functions. MEMBRANE. 2022. 47. 5. 291-296
清水裕道, 中尾裕之, 池田恵介, 中野実. 膜貫通ペプチドによる細胞膜内層のホスファチジルセリン露出誘導. 日本薬学会年会要旨集. 2022. 142年会. 26PO1-15S
中尾裕之. がん免疫療法を志向した細胞貪食誘導ペプチドの開発-Development of Phagocytosis Inducing Peptides for Cancer Immunotharapy-2020年度研究奨励金受領報告 ; 次世代創薬を志向したケミカルバイオロジー研究. 東京生化学研究会助成研究報告集. 2021. 36. 120-124
松田幹望, 池田恵介, 中尾裕之, 中野実. Effect of side chain length of acidic amino acids on pH-dependent binding, insertion, and permeation of cyclic peptides into lipid membranes. 日本膜学会年会講演要旨集(CD-ROM). 2021. 43rd
宮島綾梨, 中尾裕之, 池田恵介, 中野実. Mechanism of lipid transfer between membranes promoted by polyethylene glycols. 日本膜学会年会講演要旨集(CD-ROM). 2021. 43rd

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Books (1)：

The Frontier of Peptide Drug Discovery
2019 ISBN:9784781314174

Education (3)：

2014 - 2017 Kyoto University Graduate School of Pharmaceutical Sciences
2012 - 2014 Kyoto University Graduate School of Pharmaceutical Sciences
2008 - 2012 Kyoto University Faculty of Pharmaceutical Sciences

Professional career (1)：

博士(薬科学) (京都大学)

Work history (3)：

2019/10 - 現在 University of Toyama Faculty of Pharmaceutical sciences Assistant professor
2017/04 - 2019/09 University of Toyama Graduate School of Medicine and Pharmaceutical Science Assistant Professor
2016/04 - 2017/03 Kyoto University Graduate School of Pharmaceutical Sciences JSPS DC2

Awards (5)：

2022/06 - The Membrane Society of Japan Young Scientist Award of The Membrane Society of Japan
2019/09 - 次世代を担う若手のためのフィジカルファーマフォーラム若手研究者奨励賞
2016/09 - コロイドおよび界面化学討論会ポスター賞
2015/05 - 日本膜学会学生賞
2014/03 - 日本薬学会優秀発表賞

Association Membership(s) (6)：

BIOPHYSICAL SOCIETY (USA) , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE BIOPHYSICAL SOCIETY OF JAPAN , THE MEMBRANE SOCIETY OF JAPAN , THE JAPANESE PEPTIDE SOCIETY , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY

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