Rchr
J-GLOBAL ID：201701011049252156   Update date: Nov. 20, 2024

MURAKAMI Chiaki

ムラカミ チアキ | MURAKAMI Chiaki
Affiliation and department：
McMaster University Department of Chemistry and Chemical Biology

About McMaster University Department of Chemistry and Chemical Biology


Job title： Visiting Assistant Professor
Other affiliations (2)：
  • Chiba University  Institute for Advanced Academic Research   Project Assistant Professor
  • Chiba University  Graduate School of Science   Project Assistant Professor
Homepage URL  (1)： https://scholar.google.com/citations?user=lgRQ9pwAAAAJ&hl=ja
Research field  (1)： Functional biochemistry
Research keywords  (17)： Enzyme ,  Lipid phosphate phosphatases(LPPs) ,  sphingolipids ,  glycerophospholipids ,  protein-protein interaction ,  脂質代謝酵素 ,  biochemistry ,  LC-MS/MS ,  Phospholipase C ,  Phosphatidic acid phosphatase (PAP) ,  Sphingomyelin synthase-related protein (SMSr) ,  Diacylglycerol ,  Sphingomyelin synthase ,  Phosphatidic acid ,  Lipid signaling ,  diacylglycerol kinase ,  biochemistry of lipids
Research theme for competitive and other funds  (27)：
  • 2023 - 2028 生活習慣病とフレイルのリスクをシームレスに低減する画期的健康寿命延伸食品の開発
  • 2024 - 2027 Characterization of novel mammalian phospholipase C & Diacylglycerol kinase
  • 2026 - 2026 Innovations in the Molecular Mechanism of Diacylglycerol Phosphorylation: Effects of New Type of PLCs and Membrane Curvature
  • 2024 - 2026 Characterization of novel mammalian phospholipase Cs
  • 2024 - 2026 令和6年度日本人若手研究者研究助成金
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Papers (27)：
  • Chiaki Murakami, Kamila Dilimulati, Kyoko Atsuta-Tsunoda, Takuma Kawai, Sho Inomata, Yasuhisa Hijikata, Hiromichi Sakai, Fumio Sakane. Multiple activities of sphingomyelin synthase 2 generate saturated fatty acid- and/or monounsaturated fatty acid-containing diacylglycerol. Journal of Biological Chemistry. 2024. 107960-107960
  • Fumio Sakane, Chiaki Murakami, Hiromichi Sakai. Upstream and Downstream Pathways of Diacylglycerol Kinase Novel Phosphatidylinositol Turnover-independent Signal Transduction Pathways. Advances in Biological Regulation. 2024. 101054-101054
  • Rika Suzuki, Chiaki Murakami, Kamila Dilimulati, Kyoko Atsuta-Tsunoda, Takuma Kawai, Fumio Sakane. Human sphingomyelin synthase 1 generates diacylglycerol in the presence and absence of ceramide via multiple enzymatic activities. FEBS Letters. 2023
  • Masataka Furuta, Chiaki Murakami, Yuki Numagami, Rika Suzuki, Fumio Sakane. Diacylglycerol kinase ζ interacts with sphingomyelin synthase 1 and sphingomyelin synthase-related protein via different regions. FEBS open bio. 2023
  • Ayako Yamazaki, Ayane Kawashima, Takuya Honda, Takafumi Kohama, Chiaki Murakami, Fumio Sakane, Toshihiko Murayama, Hiroyuki Nakamura. Identification and characterization of diacylglycerol kinase ζ as a novel enzyme producing ceramide-1-phosphate. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2023. 159307-159307
ｍore...
MISC (65)：
  • 【プレスリリース】生理活性脂質代謝酵素SMS2の新たな機能を発見〜特定の脂肪酸を持つリン脂質を代謝し生理活性脂質を産生する〜. 2024
  • 村上千明, 堺弘道, 角田(熱田)京子, DILIMULATI Kamila, 川合巧真, 猪俣翔, 坂根郁夫. Orphan phosphataseのPHOSPHO1とPHOSPHO2はグリセロリン脂質を加水分解しジアシルグリセロールを産生する. 脂質生化学研究. 2024. 66
  • Chiaki Murakami. 活性発見後半世紀以上遺伝子不明の哺乳類ホスホリパーゼC酵素群の同定と機能解析. 2024. 25th
  • 角田(熱田)京子,川合 巧真,猪俣翔,Kamila Dilimulati,土方 寧久,堺 弘道,坂根 郁夫,村上千明. Orphan phosphataseのPHOSPHO2はホスファチジン酸ホスファターゼ活性を有する. 日本生化学会関東支部例会プログラム・講演要旨集. 2024
  • 猪俣翔,角田(熱田)京子,川合 巧真,Kamila Dilimulati,土方 寧久,堺 弘道,坂根 郁夫,村上千明. PHOSPHO1 はホスファチジルコリンとホスファチジルエタノールアミンのホスホリパーゼC 活性を持ちジアシルグリセロールキナーゼδと相互作用する. 日本生化学会関東支部例会プログラム・講演要旨集. 2024
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Lectures and oral presentations  (20)：
  • PHOSPHO1 exhibits PLC activity and interacts with DGK delta.
    (the 96th Japanese Biochemical Society 2024)
  • Upstream and Downstream Pathways of Diacylglycerol Kinase: Novel Phosphatidylinositol Turnover- independent Pathways
    (the 65th International Symposium of Advances in Biological Regulation “Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues” 2024)
  • Identification of new mammalian phospholipase Cs
    (the 25th Enzyme Application Symposium 2024)
  • Orphan phosphataseのPHOSPHO1とPHOSPHO2はグリセロリン脂質を加水分解しジアシルグリセロールを産生する
    (66th the Japanese Conference on the Biochemistry of Lipids 2024)
  • Novel Diacylglycerol Production/Phosphorylation Pathways Independent of the Phosphatidylinositol Turnover
    (Gordon Research Conference Molecular and Cellular Biology of Lipids 2023)
ｍore...
Works (1)：
  • Development of New Lipid Second Messenger Analytical Method Toward Green Chemistry from Chiba university
    Chiaki Murakami 2019 -
Education (3)：
  • 2018 - 2021 Chiba university Graduate School of Science and Engineering Department of Chemistry
  • 2016 - 2018 Chiba university Graduate School of Science Department of Chemistry
  • 2012 - 2016 Chiba University Faculty of Science Department of Chemistry
Professional career (3)：
  • Ph.D. (Science) (Chiba University)
  • Master of Science (Chiba University)
  • Bachelor of Science (Chiba University)
Work history (6)：
  • 2024/10 - 現在 McMaster University Department of Chemistry and Chemical Biology Visiting Assistant Professor
  • 2024/04 - 現在 Japan Society for the Promotion of Science JSPS Scientist for Joint International Research
  • 2022/05 - 現在 Chiba University Graduate School of Science Project Assistant Professor
  • 2022/05 - 現在 Chiba University Institute for Advanced Academic Research Assistant Professor
  • 2021/04 - 2022/04 Japan Society for the Promotion of Science JSPS Research Fellow (PD)
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Awards (13)：
  • 2026/01 - The Japanese Biochemical Society The Osamu Hayaishi Memorial Scholarship for Study Abroad Innovations in the Molecular Mechanism of Diacylglycerol Phosphorylation: Effects of New Type of PLCs and Membrane Curvature
  • 2024/11 - The Japanese Biochemical Society Young Scientist Award (The 97th Annual Meeting of the Japanese Biochemical Society) Human sphingomyelin synthases synthesizes long chain fatty acid-containing ceramide phosphoethanolamine
  • 2024/06 - Amano Enzyme Foundation for Science and Technology the 25th Enzyme Application Symposium Research Incentive Award Identification of new mammalian phospholipase Cs
  • 2021/11 - The Japanese Biochemical Society Young Scientist Award (The 94th Annual Meeting of the Japanese Biochemical Society) Mammalian sphingomyelin synthase-related protein displays phospholipase C activity
  • 2021/03 - Chiba University Chiba University President’s Award for Outstanding Students
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Association Membership(s) (4)：
THE JAPANESE BIOCHEMICAL SOCIETY ,  生化学若い研究者の会 ,  The American Society for Biochemistry and Molecular Biology ,  THE JAPANESE CONFERENCE ON THE BIOCHEMISTRY OF LIPIDS
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