Hayashi Hideki

ハヤシヒデキ | Hayashi Hideki

Affiliation and department：
Job title：准教授

Research field (2)： Pharmacology , Neuroscience - general

Research keywords (6)：リポタンパク質受容体 , 神経保護 , 緑内障 , 糖尿病網膜症 , 脳虚血 , 神経化学

Research theme for competitive and other funds (16)：

2024 - 2025 超音波応答性ナノバブルを用いた網膜への非侵襲性核酸医薬送達技術の開発と正常眼圧緑内障治療への応用
2022 - 2025 Developing a platform for a non-invasive glaucoma treatment system using ultrasonic nanobubbles loaded with anti-LRP1 antibody
2023 - 2024 抗LRP1抗体による新規緑内障治療法の開発研究
2018 - 2021 The neuroprotective mechanism of lipoproteins for optic nerve degeneration.
2015 - 2018 A study on neuroprotection by glia-derived lipoproteins against nerve injury

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Papers (57)：

Min Wang, Hideki Hayashi, Ichiro Horinokita, Mayumi Asada, Yui Iwatani, Jun-guo Ren, Jian-xun Liu, Norio Takagi. Role of senkyunolide I in the promotion of neural stem/progenitor cell proliferation via the Akt/β-catenin pathway. Biomedicine & Pharmacotherapy. 2023. 168. 115683-115683
Yui Iwatani, Hideki Hayashi, Haruna Yamamoto, Hayato Minamikawa, Mitsuki Ichikawa, Hayato Orikawa, Aya Masuda, Natsumi Tada, Yoshiyuki Moriyama, Norio Takagi. Pathogenic role of NAMPT in the perivascular regions after ischemic stroke in mice with type 2 diabetes mellitus. Experimental neurology. 2023. 114584
Ichiro Horinokita, Hideki Hayashi, Takamasa Nagatomo, Yuna Fushiki, Yui Iwatani, Norio Takagi. Effect of Progranulin on Proliferation and Differentiation of Neural Stem/Progenitor Cells after Oxygen/Glucose Deprivation. International journal of molecular sciences. 2022. 23. 4. 1949
Mayumi Asada, Hideki Hayashi, Norio Takagi. Possible Involvement of DNA Methylation and Protective Effect of Zebularine on Neuronal Cell Death after Glutamate Excitotoxity. Biological & pharmaceutical bulletin. 2022. 45. 6. 770-779
Hayashi H, Mori M, Harashima M, Hashizume T, Furiya M, Mukaigaito C, Takemura E, Yamada M, Mise K, Yuan B, et al. Apolipoprotein E-containing lipoproteins and LRP1 protect from NMDA-induced excitotoxicity associated with reducing α2-macroglobulin in Müller glia. Invest Ophthalmol Vis Sci. 2021. 62. 13. 23-23

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MISC (54)：

林秀樹, 森みすず, 見世加南子, YUAN Bo, 高木教夫. Neuroprotective roles of low density lipoprotein-receptor related protein 1 with reduction of alpha 2-macroglobulin in the retina. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
Asada Mayumi, Hayashi Hideki, Murakami Kenjiro, Kikuiri Kento, Kaneko Ryotaro, Yuan Bo, Takagi Norio. Roles of DNA methylation in neuronal cell death after ischemic injury. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021. 94. 1-O-C1-3
林秀樹, 高木教夫. 次世代のグリアバイオロジー〜新しい機能から疾患と創薬標的分子ハンティングまで〜グリア細胞由来リポタンパク質のLRP1を介した神経保護と緑内障治療への応用. 日本生化学会大会プログラム・講演要旨集. 2020. 93回. [1S07e-04]
袁博, 徐康, 嶋田亮太, 林秀樹, 高木教夫, 岡崎真理. Gamabufotalinによるヒトグリオブラストーマ細胞の細胞毒性およびarseniteに惹起される殺細胞効果の増強. 日本生化学会大会プログラム・講演要旨集. 2020. 93回. [P-546]
袁博, 清海杏奈, 菊地秀与, 林秀樹, 杉浦宗敏, 平野俊彦, 高木教夫, 岡崎真理. ヒト乳がん細胞に対するAsIIIとテトランドリンの併用による分化誘導作用(Differentiation induction of human breast cancer cells by arsenite in combination with tetrandrine). 日本薬学会年会要旨集. 2020. 140年会. 27Q-am168

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Patents (3)：

Books (2)：

Neuroprotection and neuroregeneration for retinal diseases
Springer, 2014
Neuroglia 3rd Edition
Oxford University Press 2012

Education (2)：

1993 - 1998 Tokyo University of Pharmacy and Life Sciences
1989 - 1993 Tokyo University of Pharmacy and Life Sciences School of Pharmacy School of Pharmacy

Professional career (1)：

博士(薬学) (東京薬科大学)

Work history (8)：

2019/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
2014/01 - 2019/03 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
2013/04 - 2013/12 Kumamoto University School of Medicine
2008/02 - 2013/03 Kumamoto University Priority Organization for Innovation and Excellence
2004/04 - 2008/01 アルバータ大学医学部リサーチアソシエイト

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Committee career (3)：

2019/02 - 現在日本薬学会代議員
2015/04 - 現在日本薬理学会学術評議員
2016/10 - 2018/10 日本薬理学会代議員

Awards (3)：

2007/10 - The Pfizer Canada-SCOLAR Publication Award
2004/10 - Canadian Lipoprotein Conference Oral presentation Award
2001/07 - Alberta Heritage Foundation for Medical Research Research Fellowship

Association Membership(s) (8)：

American Society for Biochemistry and Molecular Biology , Society for Neuroscience , JAPAN GLAUCOMA SOCIETY , THE JAPANESE SOCIETY FOR NEUROCHEMISTRY , THE JAPANESE BIOCHEMICAL SOCIETY , THE JAPANESE PHARMACOLOGICAL SOCIETY , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE JAPANESE CONFERENCE ON THE BIOCHEMISTRY OF LIPIDS

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