Kohara Yukihiro

コハラユキヒロ | Kohara Yukihiro

Affiliation and department：

Research field (2)： Metabolism and endocrinology , Anatomy

Research theme for competitive and other funds (9)：

2022 - 2025 肝臓から同定した破骨細胞阻害因子Calreticulinの骨代謝制御機構の解明
2020 - 2025 Pathophysiology of bone disorder in light of epigenetic alteration and comprehensive network of transcription factors
2024 - 脱リン酸化酵素 CTDNEP1 による骨量維持機構の解明
2024 - 骨常在型マクロファージに着目した骨粗鬆症や骨癒合不全に対する創薬シーズの探索
2019 - 2022 Functional elucidation of Emilin2 secreted by macrophages in bone metabolism and its potential for clinical application

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Papers (19)：

Chisato Sampei, Kosuke Kato, Yasuhiro Arasaki, Yuta Kimura, Takuto Konno, Kanon Otsuka, Yukihiro Kohara, Masaki Noda, Yoichi Ezura, Tadayoshi Hayata. Gprc5a is a novel parathyroid hormone-inducible gene and negatively regulates osteoblast proliferation and differentiation. Journal of cellular physiology. 2024
Yifan Qing, Takehito Ono, Yukihiro Kohara, Atsushi Watanabe, Noboru Ogiso, Masako Ito, Tomoki Nakashima, Sunao Takeshita. Emilin2 marks the landing point of mesenchymal cells for bone regeneration. Inflammation and Regeneration. 2024. in press
Takuto Konno, Hitomi Murachi, Kanon Otsuka, Yuta Kimura, Chisato Sampei, Yasuhiro Arasaki, Yukihiro Kohara, Tadayoshi Hayata. Ctdnep1 phosphatase is required for negative regulation of RANKL-induced osteoclast differentiation in RAW264.7 cells. Biochemical and Biophysical Research Communications. 2024. 150063-150063
Ryuma Haraguchi, Riko Kitazawa, Yukihiro Kohara, Yuuki Imai, Sohei Kitazawa. Novel animal model of soft tissue tumor due to aberrant hedgehog signaling activation in pericyte lineage. Cell and tissue research. 2022
Yukihiro Kohara, Riko Kitazawa, Ryuma Haraguchi, Yuuki Imai, Sohei Kitazawa. Macrophages are requisite for angiogenesis of type H vessels during bone regeneration in mice. Bone. 2022. 154. 116200-116200

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MISC (52)：

三瓶千怜, 加藤宏典, 荒崎恭弘, 木村勇太, 金野琢人, 大塚果音, 野田政樹, 野田政樹, 江面陽一, 江面陽一, et al. Gprc5a is a gene induced by PTH that functions as a repressor of BMP signaling and suppresses the proliferation and differentiation in osteoblasts. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
金野琢人, 三瓶千怜, 荒崎恭弘, 中村貴, 加藤茂明, 麻生義則, 江面陽一, 江面陽一, 西中村隆一, 小原幸弘, et al. Loss of the phosphatase Ctdnep1 in periosteal mesenchymal progenitors causes osteochondroma. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
木村勇太, 荒崎恭弘, 三瓶千怜, 西中村隆一, 小原幸弘, 早田匡芳. Deficiency of the phosphatase Ctdnep1 causes neuromuscular disorders. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
奥平准之, 秋元美穂, 諏佐崇生, 小原幸弘, 久樹晴美, 飯塚眞由, 岡崎具樹, 安達三美[玉盛]. 加齢に伴うマウスコルチコステロンの日内リズム破綻のメカニズムの解析. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 1T14a-04
原口竜摩, 小原幸弘, 北澤理子, 北澤荘平. The role of Wnt signal modulator gene, sFRP4 in the aged kidney. 日本病理学会会誌. 2022. 111. 1. 337-337

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Lectures and oral presentations (10)：

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Education (2)：

2012 - 2016 Nippon Veterinary and Life Science University
2006 - 2012 Nippon Veterinary and Life Science University Faculty of Veterinary Science School of Veterinary Medicine

Professional career (1)：

Work history (6)：

2023/04 - 現在 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Medicinal and Life Science
2022/05 - 2023/03 帝京高等看護学院
2022/04 - 2023/03 Teikyo University School of Medicine
2022/02 - 2022/03 Ehime University Graduate School of Medicine
2019/02 - 2022/01 Ehime University Graduate School of Medicine

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Committee career (3)：

Awards (16)：

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Association Membership(s) (2)：

日本分子生物学会 , JAPANESE SOCIETY FOR BONE AND MINERAL RESEARCH

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