Sato Kaoru

サトウカオル | Sato Kaoru

Affiliation and department：

Research field (5)： Pathobiochemistry , Neuropathology , Molecular biology , Systems genomics , Genomics

Research keywords (11)： Alzheimer's disease , Neurodegenerative disease , Dementia , Aging , RNA , non-coding RNA , ホルモン , 核内受容体 , Biomarker , genome , Epigenetics

Research theme for competitive and other funds (7)：

2020 - 2024 Elucidation of the mechanism of heterochromatin-dependent transcriptional activation in piRNA clusters
2019 - 2023 Small RNA pathway analysis on C. elegans and the relatives
2018 - 2020 Elucidating of Nuage formation mechanism, a Drosophila cytoplasmic granule for germline piRNA biogenesis
2016 - 2018 Elucidating of molecular mechanism of Piwi-piRNA mediated transcriptional silencing of transposons in Drosophila ovarian somatic cells
2014 - 2016 Molecular function of Maelstrom in germline piRNA biogenesis pathway in Bombyx mori

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Papers (24)：

Kaoru Sato, Ken-ichi Takayama, Yuko Saito, Satoshi Inoue. ERRα and ERRγ coordinate expression of genes associated with Alzheimer’s disease, inhibiting DKK1 to suppress tau phosphorylation. Proceedings of the National Academy of Sciences (PNAS). 2024. 121. 37. e2406854121
Ken-ichi Takayama, Takashi Suzuki, Kaoru Sato, Yuko Saito, Satoshi Inoue. Cooperative nuclear action of RNA-binding proteins PSF and G3BP2 to sustain neuronal cell viability is decreased in aging and dementia. Aging Cell. 2024. e14316
Kaoru Sato, Ken-ichi Takayama, Satoshi Inoue. Stress granule-mediated RNA regulatory mechanism in Alzheimer's disease. Geriatrics & Gerontology International. 2024. 24. S1. 7-14
Kaoru Sato, Ken-ichi Takayama, Satoshi Inoue. Expression and function of estrogen receptors and estrogen-related receptors in the brain and their association with Alzheimer’s disease. Frontiers in Endocrinology. 2023. 14. 1220150
Kaoru Sato, Ken-Ichi Takayama, Satoshi Inoue. Stress granules sequester Alzheimer's disease-associated gene transcripts and regulate disease-related neuronal proteostasis. Aging. 2023. 15. 10. 3984-4011

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MISC (6)：

大西遼, 佐藤薫, 村野健作, 根岸瑠美, 塩見春彦, 塩見美喜子. PiwiはMaelstromを介してBrm依存的なトランスポゾンを抑制する. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
大西遼, 佐藤薫, 村野健作, 高橋亜紀子, 根岸瑠美, 塩見春彦, 塩見美喜子. piRNAを介したトランスポゾン転写抑制機構におけるMaelとBrmの機能. 日本RNA学会年会要旨集. 2019. 21st
佐藤薫, 岩崎由香, 塩見美喜子, 塩見春彦. KrimpはAGO3とセンスpiRNAとの相互作用を制御することによりアンチセンスpiRNAの産生を促進する. ライフサイエンス新着論文レビュー FIRST AUTHOR'S. 2015
Kaoru Sato, Yuka W. Iwasaki, Aoi Shibuya, Carninci Piero, Hirotsugu Ishizu, Mikiko C. Siomi, Haruhiko Siomi. Krimper enforces on piRNA pools an antisense bias by binding unmethylated AGO3 in the Drosophila germline. GENES & GENETIC SYSTEMS. 2013. 88. 6. 338-338
Kaoru Sato, Kazumichi M. Nishida, Mikiko C. Siomi, Haruhiko Siomi. A possible link between piRNA biogenesis and microtubule organization in Drosophila ovaries. DIFFERENTIATION. 2010. 80. S28-S29

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Education (2)：

2004 - 2009 The University of Tokyo Graduate School of Frontier Sciences
2000 - 2004 Tokyo University of Science Faculty of Science and Technology Applied Biological Science

Professional career (1)：

Ph.D. in Lifescience

Work history (4)：

2021/05 - 現在 Tokyo Metropolitan Institute of Gerontology Researcher
2013/01 - 2021/04 The University of Tokyo Graduate School of Science Department of Biological Sciences
2012/05 - 2012/12 Keio University School of Medicine Department of Molecular Biology
2009/04 - 2012/04 Keio University School of Medicine Department of Molecular Biology

Association Membership(s) (4)：

日本基礎老化学会 , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE RNA SOCIETY OF JAPAN , 日本認知症学会

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