Matsuzaki Yasunori

マツザキヤスノリ | Matsuzaki Yasunori

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://synapse.dept.med.gunma-u.ac.jp/

Research field (2)： Animals: biochemistry, physiology, behavioral science , Neuroscience - general

Research keywords (7)： molecular biology , lentiviral vector , adeno-associated viral vector , gene therapy , marmoset , non-human primate , neuroscience

Research theme for competitive and other funds (6)：

2022 - 2023 Development of an assisted feeding method for three common marmosets at birth that balances ethical considerations and research advancement.
2017 - 2019 超効率血管脳移行AAVベクターによるマーモセットでのin vivoノックアウト
2016 - 2018 Development of gene therapy against neurodegenerative diseases using CRISPR/Cas9-based genome editing
2015 - 2018 Elucidation of cellular and nuclear signals that regulate motor learning
2014 - 2015 脊髄小脳変性症モデルとなるコモンマーモセットの作出および薬物治療の評価

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Papers (24)：

Yasunori Matsuzaki, Yuuki Fukai, Ayumu Konno, Hirokazu Hirai. Optimal AAV capsid/promoter combinations to target specific cell types in the common marmoset cerebral cortex. Mol Ther Methods Clin Dev. 2024. 32. 4
Hayato Kawabata, Ayumu Konno, Yasunori Matsuzaki, Yumika Sato, Mika Kawachi, Ryo Aoki, Saki Tsutsumi, Shota Togai, Ryosuke Kobayashi, Takuro Horii, et al. Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization. Molecular Therapy - Methods & Clinical Development. 2024. 32. 1. 101185-101185
Masashi Watanave, Mika Kawachi, Ayumu Konno, Ryo Aoki, Yuuki Fukai, Yasunori Matsuzaki, Ryosuke Kaneko, Hirokazu Hirai. Protein kinase Cγ negatively regulates the intrinsic excitability in zebrin-negative cerebellar Purkinje cells. Frontiers in Cellular Neuroscience. 2024. 18
Hayato Kawabata, Ayumu Konno, Yasunori Matsuzaki, Hirokazu Hirai. A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant. Molecular therapy. Methods & clinical development. 2023. 29. 81-92
Yukihiro Okada, Nobutake Hosoi, Yasunori Matsuzaki, Yuuki Fukai, Akito Hiraga, Junichi Nakai, Keisuke Nitta, Yoichiro Shinohara, Ayumu Konno, Hirokazu Hirai. Development of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo. Communications Biology. 2022. 5. 1

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MISC (25)：

Yasunori Matsuzaki, Masami Tanaka, Sachiko Hakoda, Tatsuki Masuda, Ryota Miyata, Ayumu Konno, Hirokazu Hirai. Neurotropic Properties of AAV-PHP.B Are Shared among Diverse Inbred Strains of Mice. Molecular Therapy. 2019. 27. 4. 700-704
Yasunori Matsuzaki, Ayumu Konno, Ryuta Mochizuki, Yoichiro Shinohara, Keisuke Nitta, Yukihiro Okada, Hirokazu Hirai. Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain. Neuroscience Letters. 2018. 665. 182-188
Yasunori Matsuzaki, Ayumu Konno, Ryuta Mochizuki, Yoichiro Shinohara, Keisuke Nitta, Yukihiro Okada, Hirokazu Hirai. Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain. Neuroscience Letters. 2018. 665. 182-188
今野歩, 渡邊将, 星野千秋, 篠原洋一郎, 松崎泰教, 平井宏和. リピート病における神経変性の分子機構解明を目指してアデノ随伴ウイルスによる遺伝子導入を介したリピート病モデル動物の作出と治療法の開発. 生命科学系学会合同年次大会. 2017. 2017年度. [3PW23-3]
Nobutaka Takahashi, Anton N. Shuvaev, Ayumu Konno, Yasunori Matsuzaki, Masashi Watanave, Hirokazu Hirai. Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells. JOURNAL OF NEUROCHEMISTRY. 2017. 143. 6. 660-670

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Lectures and oral presentations (16)：

Comparative analysis of transgene expression using nine AAV capsids in the cerebral cortex of the common marmoset
(NEURO2024 2024)
Cell type analysis of the gene expression of nine AAV capsid vectors in the cerebral cortex of the common marmoset.
(The 13th International Society of Radiation Neurobiology Conference 2024)
Expression analysis of 9 AAV capsid vectors in marmoset cortex injection
(The 13th Annual Meeting of Japan Society for Marmoset Research 2024)
Comparative analysis of nine AAV capsid vector-expressing cell types in the cerebral cortex of the marmoset
(The 29th Annual Meeting of Japan Society of Gene and Cell Therapy 2023)
Development of a method to keep three newborn marmosets in parental care by supplemental feeding
(The 12th Annual Meeting of Japan Society for Marmoset Research 2023)

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Education (3)：

2010 - 2014 Gunma University Graduate School of Medicine Neurophysiology and Neural Repair
2008 - 2010 Shinshu University Graduate School of Medicine Human Science
2004 - 2008 Kindai University Faculty of Biology-Oriented Science and Technology Department of Genetic Engineering

Work history (3)：

2015/07 - 現在 Gunma University Graduate School of Medicine Neurophysiology and Neural Repair Assistant Professor
2015/04 - 2015/06 Gunma University Graduate School of Medicine Neurophysiology and Neural Repair Postdoctoral Researcher
2014/04 - 2015/03 Gunma University Graduate School of Medicine Neurophysiology and Neural Repair Postdoctoral Researcher

Association Membership(s) (4)：

Japan Society of Gene and Cell Therapy , The Society of Primate Diseases and Pathology , The Japan Neuroscience Society , JAPAN SOCIETY OF MARMOSET RESEARCH

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