Research theme for competitive and other funds (6)：
2022 - 2023 Development of an assisted feeding method for three common marmosets at birth that balances ethical considerations and research advancement.
2016 - 2018 Development of gene therapy against neurodegenerative diseases using CRISPR/Cas9-based genome editing
2015 - 2018 Elucidation of cellular and nuclear signals that regulate motor learning
2014 - 2015 脊髄小脳変性症モデルとなるコモンマーモセットの作出および薬物治療の評価
2014 - 2015 脊髄小脳変性症モデルマーモセットの運動失調評価システムの構築
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Papers (24)：
Hayato Kawabata, Ayumu Konno, Yasunori Matsuzaki, Yumika Sato, Mika Kawachi, Ryo Aoki, Saki Tsutsumi, Shota Togai, Ryosuke Kobayashi, Takuro Horii, et al. Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization. Molecular Therapy - Methods & Clinical Development. 2024. 32. 1. 101185-101185
Masashi Watanave, Mika Kawachi, Ayumu Konno, Ryo Aoki, Yuuki Fukai, Yasunori Matsuzaki, Ryosuke Kaneko, Hirokazu Hirai. Protein kinase Cγ negatively regulates the intrinsic excitability in zebrin-negative cerebellar Purkinje cells. Frontiers in Cellular Neuroscience. 2024. 18
Hayato Kawabata, Ayumu Konno, Yasunori Matsuzaki, Hirokazu Hirai. A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant. Molecular therapy. Methods & clinical development. 2023. 29. 81-92
Yukihiro Okada, Nobutake Hosoi, Yasunori Matsuzaki, Yuuki Fukai, Akito Hiraga, Junichi Nakai, Keisuke Nitta, Yoichiro Shinohara, Ayumu Konno, Hirokazu Hirai. Development of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo. Communications Biology. 2022. 5. 1
Masashi Watanave, Nobutaka Takahashi, Nobutake Hosoi, Ayumu Konno, Hikaru Yamamoto, Hiroyuki Yasui, Mika Kawachi, Takuro Horii, Yasunori Matsuzaki, Izuho Hatada, et al. Protein kinase Cγ in cerebellar Purkinje cells regulates Ca2+-activated large-conductance K+ channels and motor coordination. Proceedings of the National Academy of Sciences. 2022. 119. 7. e2113336119-e2113336119
Cell type analysis of the gene expression of nine AAV capsid vectors in the cerebral cortex of the common marmoset.
(The 13th International Society of Radiation Neurobiology Conference 2024)
Expression analysis of 9 AAV capsid vectors in marmoset cortex injection
(The 13th Annual Meeting of Japan Society for Marmoset Research 2024)
Comparative analysis of nine AAV capsid vector-expressing cell types in the cerebral cortex of the marmoset
(The 29th Annual Meeting of Japan Society of Gene and Cell Therapy 2023)
Development of a method to keep three newborn marmosets in parental care by supplemental feeding
(The 12th Annual Meeting of Japan Society for Marmoset Research 2023)
BBB-permeable properties of AAV-PHP.B are shared among diverse inbred strains of mice
(Neuro 2019 2019)
2010 - 2014 Gunma University Graduate School of Medicine Neurophysiology and Neural Repair
2008 - 2010 Shinshu University Graduate School of Medicine Human Science
2004 - 2008 Kindai University Faculty of Biology-Oriented Science and Technology Department of Genetic Engineering
Work history (3)：
2015/07 - 現在 Gunma University Graduate School of Medicine Neurophysiology and Neural Repair Assistant Professor
2015/04 - 2015/06 Gunma University Graduate School of Medicine Neurophysiology and Neural Repair Postdoctoral Researcher
2014/04 - 2015/03 Gunma University Graduate School of Medicine Neurophysiology and Neural Repair Postdoctoral Researcher
Association Membership(s) (4)：
Japan Society of Gene and Cell Therapy
, The Society of Primate Diseases and Pathology
, The Japan Neuroscience Society
, JAPAN SOCIETY OF MARMOSET RESEARCH
