Hirotaka Chikuda

2017 - 2023 細胞周期制御性エクソソームを介した新規骨代謝カップリング因子の探索

2017 - 2020 Comprehensive research for molecular regulation of development, homeostasis, and degeneration of spine

2016 - 2020 Identification of microRNAs controlled by Cdk6 for understanding of bone metabolism system and their application for regenerative medicine

2016 - 2019 Cerebrospinal Fluid Biomarkers for Lumbar Spinal Stenosis Identified by an Exhaustive search with High-Resolution Mass Spectrometry

2016 - 2019 Basic research for a long-life spinal implant providing dynamic stability and anti-infective property

2016 - 2019 Function of RSPO2 in progerssion of OPLL

2015 - 2018 Development of mRNA medicine for treatment of neural diseases and injury

2013 - 2017 Investigation of factors which simultaneously regulate bone formation and bone resorption in terms of cell cycle regulation.

2013 - 2017 Strategic research of osteoarthritis for novel therapeutics

2014 - 2016 Analysis of the high ability of urodele amphibians to regenerate articular cartilage and application of the underlying mechanism to regeneration of mammalian cartilage

2012 - 2016 Elucidation of the mechanism of bone metabolism controlled by Cdk6 transcription factory

2012 - 2015 Analyses of IKK signaling pathway in locomotive diseases

2012 - 2015 Analyses of Notch signaling pathway in osteoarthritis

2011 - 2014 Research of Notch signal in pathophysiology and therapeutics of osteoarthritis

2011 - 2012 Establishment and application of in-vitro hypertrophic and degeneration model designed to clarify the mechanism of mechanical signal transduction in chondrocytes.

2010 - 2012 Novel therapeutic approaches to bone diseases using cell cycle factors Cdk4/6

2009 - 2012 β-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor.

2009 - 2011 Regulation of chondrocyte metabolism by transcription factor C/EBP families

2009 - 2011 Research of bone and cartilage regulation by NF-kB signal for innovative targeted therapy.

2008 - 2010 Molecular mechanisms of regulation in bone and cartilage metabolism by GSK3β

2003 - 2005 新規軟骨分化制御因子cGK2シグナルの骨再正における機能解析とその標的分子の同定

2003 - 2005 Strategic study on osteoblast and chondrocyte differentiation from embryonic stem (ES) cells