Yoshikawa Kazuhiro

Affiliation and department：
Job title：特務教授

Research field (2)： Tumor diagnostics and therapeutics , Immunology

Research keywords (5)： PTEN , がんワクチン , 抗体 , 免疫細胞療法 , がん免疫

Research theme for competitive and other funds (40)：

2021 - 2024 頸部リンパ節における腫瘍免疫環境の解明-免疫学的頸部郭清術の確立を目指して
2017 - 2023 子宮頸がんを発生させるHPVのE7蛋白を標的とした細胞内分子標的療法の開発
2019 - 2022 Efficacy and toxicity of bladder instillation of anti-tumor peptide for inhibition of bladder tumor in mice
2019 - 2022 Identification of novel causative gene for familial patellar aplasia and analysis of pathogenesis
2017 - 2022 Development of a New Immunochemotherapy for Head and Neck Cancer - Significance of Combination of CTL and Anticancer Drugs

2015 - 2018 歯髄幹細胞特性を応用した効率的組織再生療法の臨床応用ロジスティクス

2014 - 2018 Establish the rapid diagnosis system for chemosensitivity on head and neck cancer treatment

2014 - 2017 Development of novel cancer immunotherapy based on comprehensive control of effector regulatory T-cells

2012 - 2016 Combination therapy using cancer vaccine, antigen-specific CTL and an anticancer drug for renal cell carcinoma

2012 - 2016 Biomarker reserch for moyamoya disease in cerebrospinal fluid

2012 - 2015 Efficacy and toxicity of systemic transduction of p16 antitumor peptide in inhibition of metastases of urological tumors

2011 - 2013 Elucidation of CDDP sensitivity related factors on the head and neck cancer-using comprehensive proteomics analysis

2009 - 2011 New strategy of intravesical in stillation using anti-cancer peptide for bladder tumor

2009 - 2011 Application of SELDI ProteinChip system in pathogenesis of pediatric fulminamt hepatic failure

2005 - 2009 The scientific clinical study of antibody therapy

2007 - 2008 Novel molecular therapeutic strategies in prostate cancer

2007 - 2008 p27 expression and growth suppression by p27 peptide in pediatric lymphoma

2006 - 2007 Prediction of in vitro response to interferon-alpha and acquisition of its susceptibility by gene and peptide transduction system

2005 - 2006 Molecular Therapy Targeting PTEN-Akt Signaling Pathway in Prostate Cancer.

2004 - 2006 Development new generation peptides derived from CA9 as tailar-made vaccines for renal cell carcinoma

2003 - 2005 Gene expression profiling in association with interferon-alpha-sensitivity for the personalized treatment of renal cell carcinoma

2000 - 2004 抗体療法及びがんの前臨床試験研究

2002 - 2003 MN/CA9 expression and VHL regulation in renal cell carcinoma

2002 - 2003 Liver-directed gene therapy using space-mediated and remote -controlled method

2001 - 2002 Search for new target antigens of cancer by the SEREX method using cancer patient's serum containing antibodies

2001 - 2002 Active specific immunotherapy with MN\CA IX antigen peptide vaccines for renal cell carcinoma

2001 - 2002 Chromosomal abnormality of chromosome 12 in pediatric lymphoma: Prognostic impact and tumor biology

2000 - 2002 Clinical Significance for detection of circulating renal cancer cells in the blood by RT-PCR

2000 - 2000 抗腫瘍単鎖抗体の作製とその臨床応用のための基礎的検討

1999 - 2000 Specific immunotherapy targeting MN/CA9 tumor-associated antigen for renal cell carcinoma

1999 - 2000 Suppression of tumor growth and metastasis via apoptosis induced specifically in endothelial cells by caspin/PEDF/EPC-1

1999 - 1999 抗腫瘍単鎖抗体の作製とその臨床応用のための基礎検討

1998 - 1999 Molecular cloning of highly expressed genes in renal cell carcinoma using cifferential display system

1998 - 1999 Establishment of diagnosis and therapy in renal cell carcinomas by MN/CAIX antibody

1998 - 1998 PDIファミリー蛋白質のシャペロン機能に関する研究

1998 - 1998 抗腫瘍単鎖抗体の作製とその臨床応用のための基礎的検討

1997 - 1998 Molecular detection of circulating renal cell carcinoma cells by RT-PCR

1996 - 1997 Analysis of the expression and function of T cell differentiation antigen-CD7

1995 - 1997 Clinical and Immunological study of Rheumatoid Arthritis

1993 - 1994 Analysis of the expression and function of T cell differentiation antigen-CD7

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Papers (190)：

Susumu Suzuki, Toyonori Tsuzuki, Masato Saito, Toshihiko Ishii, Taishi Takahara, Akira Satou, Daisuke Inukai, Shunpei Yamanaka, Kazuhiro Yoshikawa, Ryuzo Ueda, et al. Regulatory T-cells activated in metastatic draining lymph nodes possibly suppress cancer immunity in cancer tissues of head and neck squamous cell cancer. Pathology international. 2024
Mamoru Harada, Hitoshi Kotani, Yuichi Iida, Ryosuke Tanino, Takafumi Minami, Yoshihiro Komohara, Kazuhiro Yoshikawa, Hirotsugu Uemura. Hypoxia-related carbonic anhydrase 9 induces serpinB9 expression in cancer cells and apoptosis in T cells via acidosis. Cancer Science. 2024
Shinji Ota, Kinya Yokoyama, Fumiaki Kanamori, Takashi Mamiya, Kenji Uda, Yoshio Araki, Toshihiko Wakabayashi, Kazuhiro Yoshikawa, Ryuta Saito. Moyamoya disease-specific extracellular vesicle-derived microRNAs in the cerebrospinal fluid revealed by comprehensive expression analysis through microRNA sequencing. Acta neurochirurgica. 2023. 165. 8. 2045-2055
Hiroki Okamoto, Kazuhiro Yoshikawa, Akiko Shimada, Rui Sano, Daisuke Inukai, Shunpei Yamanaka, Susumu Suzuki, Ryuzo Ueda, Hiromi Ueda, Yasushi Fujimoto, et al. Artesunate and cisplatin synergistically inhibit HNSCC cell growth and promote apoptosis with artesunate-induced decreases in Rb and phosphorylated Rb levels. Oncology reports. 2023. 50. 2
Takahiro Oike, Naoto Osu, Yuya Yoshimoto, Hideru Obinata, Kazuhiro Yoshikawa, Curtis C Harris, Tatsuya Ohno. Pilot study of plasma creatine riboside as a potential biomarker for cervical cancer. Heliyon. 2023. 9. 6. e16684

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MISC (398)：

田中紘也, 孫汀, 鬼無洋, 神谷圭介, 山口真, 野畑宏信, 久能木俊之介, 吉川和宏, 石本卓嗣, 伊藤恭彦. 腎不全マウスにおいて抗IL-6受容体抗体は食塩負荷が惹起する心臓の炎症と線維化を抑制する. 日本腎臓学会誌. 2022. 64. 3. 271-271
Yutaro Kondo, Taishi Takahara, Shoya Ono, Mitsuo Goto, Tetsuya Ogawa, Hideaki Ito, Akira Sato, Toyonori Tsuzuki, Kazuhiro Yoshikawa, Ryuzo Ueda, et al. Transforming growth factor-beta inhibitor is a candidate drug for immunotherapy of oral squamous cell carcinoma. CANCER SCIENCE. 2022. 113
Shunpei Yamanaka, Susumu Suzuki, Hideaki Ito, Shoya Ono, Yutaro Kondo, Daisuke Inukai, Hiroki Okamoto, Taishi Takahara, Toyonori Tsuzuki, Kazuhiro Yoshikawa, et al. Establishment passive culture cells derived from mucoepidermoid carcinoma. CANCER SCIENCE. 2022. 113. 1743-1743
Yutaro Kondo, Susumu Suzuki, Mitsuo Goto, Shoya Ono, Tetsuya Ogawa, Kazuhiro Yoshikawa, Toyonori Tsuzuki, Ryuzo Ueda. PD-L1 expression mechanisms are heterogeneous in oral cancer. CANCER SCIENCE. 2021. 112. 863-863
Yurie Kura, Kazuko Sakai, Yoshihiko Fujita, Masahiro Nozawa, Kazuhiro Yoshikawa, Kazuto Nishio, Marco A. De Velasco, Hirotsugu Uemura. Profiling the fecal microbiome of mouse Pten-deficient prostate cancer. CANCER SCIENCE. 2021. 112. 261-261

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Patents (3)：

Professional career (1)：

医学博士 (愛知医科大学)

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