Rchr
J-GLOBAL ID：201701018685256603   Update date: Sep. 30, 2024

Nagai Hirotaka

ナガイ ヒロタカ | Nagai Hirotaka
Affiliation and department：
Kobe University Graduate School of Medicine Faculty of Medical Sciences

About Kobe University Graduate School of Medicine Faculty of Medical Sciences


Job title： Assistant Professor
Research field  (2)： Neuroscience - general ,  Pharmacology
Research keywords  (7)： 樹状突起 ,  シナプス ,  中央代謝系 ,  前頭前皮質 ,  老化 ,  精神疾患 ,  ストレス
Research theme for competitive and other funds  (3)：
  • 2020 - 2023 社会ストレスによる樹状突起委縮を担う分子機序の解明とその制御法の確立
  • 2018 - 2021 Ultrastructural analysis of social stress-induced neuron-glia interaction underlying neuronal morphological alterations
  • 2009 - 2011 アスベスト誘発発癌機構の解明とその予防
Papers (33)：
  • Hirotaka Nagai. Deciphering Prefrontal Circuits Underlying Stress and Depression: Exploring the Potential of Volume Electron Microscopy. Microscopy (Oxford, England). 2024
  • Io Horikawa, Hirotaka Nagai, Masayuki Taniguchi, Guowei Chen, Masakazu Shinohara, Tomohide Suzuki, Shinichi Ishii, Yoshio Katayama, Shiho Kitaoka, Tomoyuki Furuyashiki. Chronic stress alters lipid mediator profiles associated with immune-related gene expressions and cell compositions in mouse bone marrow and spleen. Journal of pharmacological sciences. 2024. 154. 4. 279-293
  • Satoshi Akiyama, Hirotaka Nagai, Shota Oike, Io Horikawa, Masakazu Shinohara, Yabin Lu, Takashi Futamura, Ryota Shinohara, Shiho Kitaoka, Tomoyuki Furuyashiki. Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice. Scientific Reports. 2022. 12. 1
  • Yusuke Kawashima, Hirotaka Nagai, Ryo Konno, Masaki Ishikawa, Daisuke Nakajima, Hironori Sato, Ren Nakamura, Tomoyuki Furuyashiki, Osamu Ohara. Single-Shot 10K Proteome Approach: Over 10,000 Protein Identifications by Data-Independent Acquisition-Based Single-Shot Proteomics with Ion Mobility Spectrometry. Journal of proteome research. 2022. 21. 6. 1418-1427
  • Hirotaka Nagai, Luisa de Vivo, William Marshall, Giulio Tononi, Chiara Cirelli. Effects of Severe Sleep Disruption on the Synaptic Ultrastructure of Young Mice. eneuro. 2021. 8. 4. ENEURO.0077-21.2021
ｍore...
MISC (59)：
  • NAGAI Midori, NAGAI Hirotaka, NUMA Chisato, NADANAKA Satomi, KAWASHIMA Yusuke, OHNO Nobuhiko, KITAGAWA Hiroshi, FURUYASHIKI Tomoyuki. Social stress induces microglial contact with synapses, contributing to the release of heparan sulfate from synaptic proteoglycans in mice. 日本薬理学会年会要旨集(Web). 2023. 97th
  • 沼知里, 永井裕崇, 永井碧, 山下朋美, 川島祐介, 大野伸彦, 片岡洋祐, 片岡洋祐, 三森(清末)優子, 加藤太朗, et al. マウスの社会ストレスは前頭前皮質錐体神経細胞の樹状突起消失に先行して細胞内変性を誘導する. 日本神経化学会大会抄録集(Web). 2022. 65th
  • Numa Chisato, Nagai Hirotaka, Nagai Midori, Yamashita Tomomi, Kawashima Yusuke, Ohno Nobuhiko, Kataoka Yosky, Mimori-Kiyosue Yuko, Kato Taro, Furuyashiki Tomoyuki. Roles of synaptic mitochondrial regulations for stress susceptibility. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 1-SS-13
  • Nagai Hirotaka, Nagai Midori, Numa Chisato, Yamashita Tomomi, Kawashima Yusuke, Ohno Nobuhiko, Kataoka Yosky, Shimma Shuuichi, Mimori-Kiyosue Yuko, Kato Taro, et al. Chronic social stress alters synaptic central metabolism for depression. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 1-YIA-11
  • Rui Yamada, Nagai Hirotaka, Numa Chisato, Horikawa Io, Nagai Midori, Kawashima Yusuke, Furuyashiki Tomoyuki. Analysis of aging-induced neural dysfunctions and their biological basis. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 1-SS-43
ｍore...
Books (2)：
  • Rang & Dale's Pharmacology, 8e
    2018
  • ナノカーボンの応用と実用化-フラーレン、ナノチューブ、グラフェンを中心に-
    シーエムシー出版 2011
Lectures and oral presentations  (13)：
  • Subcellular mechanisms of social stress
    (2021)
  • 三次元電子顕微鏡法
    (文部科学省新学術領域研究「マルチスケール精神病態の構成的理解」第3回若手育成セミナー「神経回路の可視化・操作・モデリングのための最先端技術」 2020)
  • Social stress-induced ultrastructural alterations of prefrontal neurons in mice
    (第50回日本神経精神薬理学会年会、第42回日本生物学的精神医学会年会、第4回日本精神薬学会総会・学術集会 合同年会 2020)
  • Analysis of ultrastructural alterations in the mouse medial prefrontal cortex toward the understanding of pathophysiology of social stress-induced depressive-like behaviors
    (第125回日本解剖学会全国学術集会 2020)
  • 研究への情熱はどこからくるか
    (第30回日本医学会総会2019中部 2019)
ｍore...
Education (2)：
  • 2004 - 2014 Kyoto University Faculty of Medicine Department of Medical Science
  • 2008 - 2012 Kyoto University Graduate School of Medicine
Professional career (1)：
  • 博士(医学) (京都大学)
Work history (8)：
  • 2019/04 - 現在 Kobe University Graduate School of Medicine
  • 2017/10 - 現在 Ministry of Education,Culture,Sports,Science and Technology
  • 2017/10 - 2019/03 Kobe University Graduate School of Medicine
  • 2014/08 - 2017/07 University of Wisconsin-Madison Department of Psychiatry Research Associate
  • 2014/08 - 2016/08 日本学術振興会 海外特別研究員
Show all
Association Membership(s) (4)：
THE JAPANESE PHARMACOLOGICAL SOCIETY ,  THE JAPAN NEUROSCIENCE SOCIETY ,  THE JAPANESE ASSOCIATION OF ANATOMISTS ,  日本精神神経薬理学会
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