NAKAGAWA Osamu

ナカガワオサム | NAKAGAWA Osamu

Research field (3)： Pharmaceuticals - chemistry and drug development , Chemical biology , Biochemistry

Research keywords (4)： Nucleic Acid Chemistry , Oligonucleotide Therapeutics , Bioorganic Chemistry , Organic Chemistry

Research theme for competitive and other funds (6)：

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Papers (58)：

Taiki Matsubayashi, Kotaro Yoshioka, Su Su Lei Mon, Maho Katsuyama, Chunyan Jia, Takao Yamaguchi, Rintaro Iwata Hara, Tetsuya Nagata, Osamu Nakagawa, Satoshi Obika, et al. Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2′,4′-BNA/LNA with 9-(aminoethoxy)phenoxazine. Molecular Therapy - Nucleic Acids. 2024. 102161
Yamaji R, Nakagawa O, Kishimoto Y, Fujii A, Matsumura T, Nakayama T, Kamada H, Osawa T, Yamaguchi T, Obika S. Synthesis and physical and biological properties of 1,3-diaza-2-oxophenoxazine-conjugated oligonucleotides. Bioorganic & Medicinal Chemistry. 2022. 72. 116972
Kishimoto Y, Fujii A, Nakagawa O, Obika S. Enhanced Duplex- and Triplex-forming Ability and Enzymatic Resistance of Oligodeoxynucleotides Modified by a Tricyclic Thymine Derivative. Organic & Biomolecular Chemistry. 2021. 19. 37. 8063-8074
Nakagawa O, Aoyama H, Fujii A, Kishimoto Y, Obika S. Crystallographic Structure of Novel Types of Ag^I-Mediated Base Pairs in Non-canonical DNA Duplex Containing 2′-O,4′-C-Methylene Bridged Nucleic Acids. Chemistry - A European Journal. 2021. 27. 11. 3842-3848
Kishimoto Y, Nakagawa O, Fujii A, Yoshioka K, Nagata T, Yokota T, Hari Y, Obika S. 2′,4′-BNA/LNA with 9-(2-Aminoethoxy)-1,3-diaza-2-oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance**. Chemistry - A European Journal. 2021. 27. 7. 2427-2438

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Patents (2)：

Method for quantitatively detecting 8-oxo-2'-deoxyguanosine in aqueous sample solution with high sensitivity, and fluorescent probe molecule
Targeted Intercellular Delivery of Oligonucleotides via Conjugation with Small Molecule Ligands

Books (5)：

Lectures and oral presentations (124)：

Synthesis and in vivo evaluation of 9-aminoethoxy-1,3-diaza-2-oxophenoxazine conjugated antisense oligonucleotides
(The 48th International Symposium on Nucleic Acids Chemistry (ISNAC2021), The 5th Annual Meeting of Japan Society of Nucleic Acids Chemistry 2021)
DNAやRNAを用いた新しい医薬品
(徳島文理高等学校 (令和3年度キャリア教育推進事業 (高校1年生) 第2回) 2021)
9-アミノエトキシフェノキサジンコンジュゲートオリゴ核酸の合成と評価
(日本薬学会第140年会 2020)
9-アミノエトキシフェノキサジン塩基を有するグリコール核酸の合成と評価
(日本薬学会第140年会 2020)
Evaluation of oligodeoxynucleotides containing tricyclic 2-oxobenzo[b][1,8]naphthyridine that targets adenine nucleobase
(The 100th Annual Meeting 2020 of CSJ 2020)

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Education (1)：

Professional career (1)：

Work history (7)：

2021/04 - 2021/12 Osaka University Graduate School of Pharmaceutical Sciences Guest Associate Professor
2020/04 - 2021/12 Tokushima Bunri University Faculty of Pharmaceutical Sciences Associate Professor
2014/04 - 2020/03 Osaka University Graduate School of Pharmaceutical Sciences Specially Appointed Associate Professor
2011/08 - 2014/03 Osaka University of Pharmaceutical Sciences Research Associate
2009/04 - 2011/07 The University of North Carolina at Chapel Hill UNC Eshelman School of Pharmacy Postdoctoral Research Associate

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Awards (1)：

2014/01 - The Pharmaceutical Society of Japan Kansai Branch, Award for Young Scientists

Association Membership(s) (2)：

The Pharmaceutical Society of Japan , The Chemical Society of Japan

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