Rchr
J-GLOBAL ID:201801000317920804
Update date: Jan. 31, 2024
Asahi Michio
Asahi Michio
Affiliation and department:
Job title:
Professor
Research field (3):
Pharmacology
, Pathobiochemistry
, Cardiology
Research keywords (7):
心不全
, カルシウムシグナル
, phospholamban
, O-GlcNAc修飾
, ライソゾーム病
, オートファジー
, ユビキチンリガーゼ
Research theme for competitive and other funds (20):
- 2022 - 2025 がん分子標的治療薬起因性心臓機能障害モデル樹立とメカニズム解析
- 2022 - 2025 NSAIDs起因性小腸粘膜傷害におけるオートファジーの関与と治療戦略の構築
- 2022 - 2025 Research on the pathophysiology of acute transient psychosis using animal model
- 2022 - 2025 心不全の進行におけるSOCE制御因子SARAFとその安定化分子ALG-2の関与
- 2021 - 2024 O-GlcNAc修飾による癌微小環境制御機能の解析
- 2021 - 2024 心不全の発症、病期進行に関与する無菌性炎症機構の解明と治療戦略の構築
- 2021 - 2023 STIM1に着目した心リハ効果の分子機構の解明と相乗効果が期待できる薬物の探索
- 2020 - 2023 糖転移酵素による糖尿病合併癌の制御メカニズムの解明と治療戦略の構築
- 2019 - 2022 Elucidation of the mechanism of PLN degradation by Parkin
- 2019 - 2022 A gene delivery microdevice utilizing atmospheric pressure plasma targeting for single cells
- 2019 - 2022 Elucidating Molecular Mechanisms of the Hepatotoxicity associated with Targeted Cancer Therapies
- 2017 - 2020 Role of TME O-GlcNAcylation in cancer proliferation
- 2016 - 2019 Effect of elevated O-GlcNAc modification on onset of gastric and colon cancer
- 2013 - 2017 Role of glycosylation on the functions of cardiac calcium regulating proteins and ion channels
- 2012 - 2015 Control of EMT phenomenon by mTOR inhiibitor for ovarian clear cell carcinoma.
- 2011 - 2014 Regulation of L-type calcium channel by intracellular subunit in cardiac hypertrophy and failure.
- 2009 - 2014 Novel approach of induction of donor specific immune tolerance: adoptive transfer of Treg cells combined with MF1 gene transfection
- 2010 - 2012 Functional analyses on the glycosylation in cardiac calcium-regulating proteins and ion channels
- 2007 - 2008 The regulatory mechanism on cardiac SR proteins by O-linked N-acetyl glucosamine
- 2005 - 2006 Molecular mechanism of the regulating factors for sarcoplasmic reticulum Ca-ATPase
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Papers (134):
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Yasuhito Fujisaka, Takatoshi Nakagawa, Kiichiro Tomoda, Marina Watanabe, Ninso Matsunaga, Yosuke Tamura, Soichiro Ikeda, Akihisa Imagawa, Michio Asahi. The cytotoxicity of gefitinib on patient-derived induced pluripotent stem cells reflects gefitinib-induced liver injury in the clinical setting. Oncology letters. 2023. 26. 6. 520-520
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Mahito Matsuno, Shunichi Yokoe, Takehiro Nagatsuka, Hirofumi Morihara, Kazumasa Moriwaki, Michio Asahi. O-GlcNAcylation-induced GSK-3β activation deteriorates pressure overload-induced heart failure via lack of compensatory cardiac hypertrophy in mice. Frontiers in Endocrinology. 2023. 14
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Shunichi Yokoe, Tetsuya Hayashi, Takatoshi Nakagawa, Ryuji Kato, Yoshio Ijiri, Takehiro Yamaguchi, Yasukatsu Izumi, Minoru Yoshiyama, Michio Asahi. Augmented O-GlcNAcylation exacerbates right ventricular dysfunction and remodeling via enhancement of hypertrophy, mitophagy, and fibrosis in mice exposed to long-term intermittent hypoxia. Hypertension research : official journal of the Japanese Society of Hypertension. 2023. 46. 3. 667-678
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Mime Kobayashi, Kiichiro Tomoda, Hirofumi Morihara, Michio Asahi, Tetsuji Shimizu, Shinya Kumagai. Non-thermal atmospheric-pressure plasma potentiates mesodermal differentiation of human induced pluripotent stem cells. Heliyon. 2022. 8. 12. e12009-e12009
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Kazumasa Moriwaki, Masaki Wada, Hiroko Kuwabara, Yusuke Ayani, Tetsuya Terada, Masaaki Higashino, Ryo Kawata, Michio Asahi. BDNF/TRKB axis provokes EMT progression to induce cell aggressiveness via crosstalk with cancer-associated fibroblasts in human parotid gland cancer. Scientific reports. 2022. 12. 1. 17553-17553
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MISC (74):
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野村 篤生, 林 哲也, 加藤 隆児, 井尻 好雄, 山口 雄大, 泉 康雄, 葭山 稔, 朝日 通雄. Glycogen synthase kinase-3およびNF-K Bp65のO-GlcNAcylationの増強は睡眠時無呼吸関連の間欠的低酸素状態によって誘発される心肥大を予防する(Augmented O-GlcNAcylation of Glycogen Synthase Kinase-3Β and NF-Κ Bp65 Prevents Cardiac Hypertrophy Induced by Intermittent Hypoxia Relevant to Sleep Apnea). 日本循環器学会学術集会抄録集. 2019. 83回. PJ074-2
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山本 ゆい, 兼崎 絢汰, 尾形 竜樹, 松本 奨太, 細川 彩, 山本 華菜子, 野村 篤生, 禹 英喜, 今野 秀樹, 加藤 隆児, et al. 肺動脈性肺高血圧症における心臓ステロイド産生急性調節タンパク質の役割 鉱質コルチコイド受容体遮断薬と抗凝固薬による新しい治療(Role of Cardiac Steroidogenic Acute Regulatory Protein in Pulmonary Arterial Hypertension: A Novel Treatment with Mineralocorticoid Receptor Antagonists and Anticoagulant). 日本循環器学会学術集会抄録集. 2019. 83回. PJ126-3
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野村 篤生, 林 哲也, 加藤 隆児, 井尻 好雄, 山口 雄大, 泉 康雄, 葭山 稔, 朝日 通雄. Augmented O-GlcNAcylation of Glycogen Synthase Kinase-3Β and NF-Κ Bp65 Prevents Cardiac Hypertrophy Induced by Intermittent Hypoxia Relevant to Sleep Apnea(和訳中). 日本循環器学会学術集会抄録集. 2019. 83回. PJ074-2
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山本 ゆい, 兼崎 絢汰, 尾形 竜樹, 松本 奨太, 細川 彩, 山本 華菜子, 野村 篤生, 禹 英喜, 今野 秀樹, 加藤 隆児, et al. Role of Cardiac Steroidogenic Acute Regulatory Protein in Pulmonary Arterial Hypertension: A Novel Treatment with Mineralocorticoid Receptor Antagonists and Anticoagulant(和訳中). 日本循環器学会学術集会抄録集. 2019. 83回. PJ126-3
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柿本 一城, 窪田 美紀, 光林 永子, 中沢 啓, 平田 有基, 川上 研, 竹内 利寿, 中川 孝俊, 朝日 通雄, 樋口 和秀. 小腸に対する基礎研究からのアプローチ 腸上皮細胞のオートファジー欠損は酸化ストレス応答を介して腸炎を増悪させる. 日本小腸学会学術集会プログラム・抄録集. 2018. 56回. 31-31
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