Rchr
J-GLOBAL ID:201801000347444985
Update date: Oct. 25, 2024
Daikoku Takiko
Daikoku Takiko
Affiliation and department:
Research field (3):
Pharmaceuticals - health and biochemistry
, Laboratory animal science
, Tumor biology
Research keywords (5):
卵巣癌
, 胚着床
, 妊娠
, 子宮体癌
, マウスモデル
Research theme for competitive and other funds (46):
- 2024 - 2027 食事による概日リズム調節と子宮蠕動運動-新たな産科婦人科疾患予防法の探索-
- 2024 - 2027 ケモカイン受容体を標的としたラジオセラノスティクスプローブの開発
- 2024 - 2027 異常な空腹ストレスによる摂食制御機構の破綻-思春期の摂食障害と次世代への影響-
- 2024 - 2027 概日リズムの乱れに伴う生殖・周産期疾患の発生機序解明とプレコンセプションケア開発
- 2024 - 2026 独自の改良型子宮内膜オルガノイドを応用した着床機構および着床不全の病態の解明
- 2022 - 2026 脈管内がん幹細胞の胚シグナル分子による微小環境形成機構とそれを標的にした治療戦略
- 2022 - 2025 Application of chronobiology to uterine leiomyomas and infertility
- 2022 - 2025 フィブリン形成を介した腹水卵巣癌細胞の新しいTME形成機序
- 2021 - 2025 思春期の欠食とダイエットで性差をもって“リプログラミング”される食欲と代謝効率
- 2021 - 2025 新規胚シグナルlaeverinの幹細胞と免疫システムに対する作用の解明と臨床応用
- 2022 - 2024 Basic research to elucidate the impact of genomic diversity acquisition on the endometrial embryo implantation environment and carcinogenesis inhibition
- 2021 - 2024 健康寿命延伸のための新たな試み:クレアチンの生体機能に着目して
- 2021 - 2024 Elucidation of pathophysiology and treatment strategies of peripheral clock disruption
- 2021 - 2024 タモキシフェンがもたらす子宮内膜の特徴的細胞変化の分子基盤と薬物有害反応への関与
- 2021 - 2024 栄養膜細胞特異抗原を用いた末梢血循環腫瘍細胞の検出と新規転移抑制治療法の開発
- 2021 - 2024 Development of tumor-host integrative therapies to overcome the refractory nature of uterine serous carcinoma
- 2020 - 2023 乳癌患者におけるタモキシフェンによる子宮内膜器質性変化の解析と妊孕性に及ぼす影響
- 2020 - 2023 閉経後ホルモン依存性子宮体癌の発症・進展の新たな分子機構 -男性ホルモン作用の解析と臨床応用-
- 2020 - 2023 Elucidation of the mutual response of epithelium and stoma that controls cancer initiation with uterine cancer mouse models
- 2019 - 2023 脳萎縮抑制を介した抗老化/神経変性疾患治療の新たな試み:クレアチン誘導体を用いて
- 2020 - 2022 Analysis of the mechanisms of induction of cancer initiation/progression by abnormal peripheral circadian rhythm using cancer mouse models
- 2019 - 2022 生後早期の母子関係を評価する新規バイオマーカーの開発 -発達障害回避を目指して-
- 2019 - 2022 Comprehensive analysis of female reproductive dysfunction induced by clock gene memory due to asynchronous feeding rhythm
- 2019 - 2022 概日リズムによる子宮収縮制御機構に着目した産婦人科疾患予防法の探索
- 2019 - 2022 Basic research on the mechanism of peritoneal dissemination of ovarian cancer and therapeutic strategies targeting the coagulation system
- 2017 - 2020 Promoting mechnisms of embryonic signals in embryo implantation induced by the immune system
- 2018 - 2020 Induction of predisposition to squamous cell carcinogenesis in esophagus by genome editing of metabolic enzymes
- 2018 - 2020 Identify suppressors of sarcoma initiation with newly established uterine sarcoma mouse model to develop novel molecular targeted therapy
- 2017 - 2020 Effect of tamoxifen administration on endometrial implantation in breast cancer patients and analysis of its mechanism of action
- 2017 - 2020 Analysis of versican involved in human embryo implantation
- 2016 - 2019 Analysis of soluble factor in menstrual blood or follicular fluid associated with fallopian tubal carcinogenesis
- 2015 - 2019 How does ADHD develop? : Targeting on creatine metabolism in brain
- 2018 - 2019 マウスモデルを用いた子宮内膜間質肉腫発生機序の解析
- 2017 - 2019 Identification and analysis of circulating embryonic stem cells derived from human chorionic stroma at early stage
- 2016 - 2019 子宮選択的Pten変異による体癌自然発症マウスを用いた増悪因子と作用機序の解析
- 2016 - 2018 Development of novel therapeutic methods targeting the driver gene STAT1 of serous papillary endometrial cancer
- 2016 - 2018 Establishment and analysis of endometrial cancer models engineered by novel genetic engineering method
- 2016 - 2017 Analysis of chorionic villi-derived embryo stem cells by novel sten cell markers, laeberin and hTERT
- 2014 - 2017 Identification of embryo-derived implantation-inducing factors (embryonic signals) and their clinical application
- 2016 - 2017 子宮体癌進行への卵巣ホルモンの影響
- 2010 - 2011 In pursuit of Lgr5 regulation and function in the uterus
- 2010 - 2011 Pten-Akt-Cox2 signaling axis in endometrial cancer.
- 2008 - 2010 A novel mouse model of endometrium-specific cancer
- 2006 - 2008 PPARδ is a Downstream Target of COX-1 Derived Prostaglandins in Ovarian Cancer
- 2007 - 2008 A Novel Mouse Model of Endometrial-Specific Cancer
- 2004 - 2005 Cyclooxygenase-1 Derived Prostacyclin Enhances Ovarian Cancer via Peroxisome Proliferator-Activated Receptor-delta
Show all
Papers (104):
-
Yuchen Chen, Takashi Hosono, Masanori Ono, Takiko Daikoku, Natsumi Toyoda, Satoshi Nomura, Kyosuke Kagami, Shunsuke Orisaka, Shin-Ichi Horike, Yifan Shi, et al. Comparison of the effects of inappropriate meal timing-induced and genetic models of circadian clock disruption on uterine mRNA expression profiles. The Journal of nutrition. 2024
-
Pingping Xu, Jun-Ichi Morishige, Zheng Jing, Naoto Nagata, Yifan Shi, Tomohiro Iba, Takiko Daikoku, Masanori Ono, Yoshiko Maida, Tomoko Fujiwara, et al. Exenatide administration time-dependently affects the hepatic circadian clock through glucagon-like peptide-1 receptors in the central nervous system. Biochemical pharmacology. 2024. 230. Pt 1. 116567-116567
-
Masanori Ono, Yuko Hayashizaki, Shunichiro Orihara, Mariko Kitamizu, Chiyo Hamada, Miki Yamaguchi, Takayuki Kikuchi, Tomomi Kawamura, Akina Yamanaka, Keiko Ueno, et al. Impact of daily breakfast intake on the outcomes of assisted reproductive technology procedures. Nutrition (Burbank, Los Angeles County, Calif.). 2024. 127. 112555-112555
-
Hiroshi Arakawa, Naoki Ishida, Tomoki Nakatsuji, Natsumi Matsumoto, Rikako Imamura, Dai Shengyu, Karin Araya, Shin-Ichi Horike, Rieko Tanaka-Yachi, Mureo Kasahara, et al. Endoplasmic reticulum transporter OAT2 regulates drug metabolism and interaction. Biochemical pharmacology. 2024. 225. 116322-116322
-
Kayo Kayahashi, Mahadi Hasan, Anowara Khatun, Susumu Kohno, Jumpei Terakawa, Shin-Ichi Horike, Natsumi Toyoda, Ayumi Matsuoka, Takashi Iizuka, Takeshi Obata, et al. Androgen-responsive FOXP4 is a target for endometrial carcinoma. Communications biology. 2024. 7. 1. 740-740
more...
MISC (12):
-
野村学史, 細野隆, 小野政徳, 大黒多希子, 三枝理博, 鏡京介, 陳雨晨, 史一帆, 盛重純一, 藤原智子, et al. 若齢雌マウスにおいて摂餌リズムと明暗サイクルの脱同期は子宮の体内時計を障害する. 日本生殖医学会雑誌. 2024. 69. 1/2
-
神田龍人, 鏡京介, 飯塚崇, 笠間春輝, 松本多圭夫, 坂井友哉, 鈴木拓馬, 山本惠, 松岡歩, 山崎玲奈, et al. Swan71細胞株はスフェロイド培養でケモカインの発現が上昇する. 日本絨毛性疾患研究会・日本胎盤学会学術集会プログラム・抄録集. 2023. 41st-31st
-
大黒多希子, 寺川純平, 松岡歩, 水本泰成, 藤原浩. 子宮がん発生を制御する分子機構の解明. がんと代謝研究会プログラム&抄録集. 2022. 8th
-
Masanori Ono, Natsumi Toyoda, Takashi Hosono, Kyosuke Kagami, Jumpei Terakawa, Tomoko Fujiwara, Mieda Michihiro, Hitoshi Ando, Hiroshi Fujiwara, Takiko Daikoku. UTERINE-SPECIFIC BMAL1 DELETION DISRUPTS MATERNAL NEOVASCULARIZATION DURING DECIDUALIZATION/PLACENTATION AND LEADS TO MISCARRIAGE DEATH. PLACENTA. 2021. 114. 141-142
-
並木貴文, 唐釜春実, 寺川純平, 大黒多希子, 影山敦子, 長谷川嘉則, 小原収, 伊藤潤哉, 柏崎直巳. 子宮上皮Gp130は転写抑制因子Snail1の発現およびエストロゲン応答性の減弱を介してマウス胚着床を誘起する. 日本絨毛性疾患研究会・日本胎盤学会学術集会プログラム・抄録集. 2021. 39th-29th
more...
Books (2):
-
HORMONE FRONTIER IN GYNECOLOGY
2023
-
ヒトゲノム事典
一色出版 2021 ISBN:9784910389127
Lectures and oral presentations (30):
-
Bmal1時計遺伝子欠損マウスにおける 胎盤形成不全
(第62回日本先天異常学会学術集会 2022)
-
子宮がん発生を制御する分子機構の解明
(第8回 がんと代謝研究会 in佐渡 2022)
-
マウスモデルを用いた子宮体癌発症・進展に対する女性ホルモンの影響についての解析
(第26回 日本生殖内分泌学会学術集会 2022)
-
UTERINE-SPECIFIC BMAL1 DELETION DISRUPTS MATERNAL NEOVASCULARIZATION DURING DECIDUALIZATION/PLACENTATION AND LEADS TO MISCARRIAGE DEATH
(PLACENTA 2021)
-
子宮特異的Bmal1欠損は脱落膜および胎盤における母体側の血管新生を抑制し流死産を誘発する
(日本絨毛性疾患研究会・日本胎盤学会学術集会プログラム・抄録集 2021)
more...
Education (3):
- 1997 - 2000 The University of Tokushima
- 1995 - 1997 The University of Tokushima
- 1991 - 1995 The University of Tokushima Faculty of Pharmaceutical Sciences
Work history (8):
- 2021/04 - 現在 Kanazawa University Division of Animal Disease Model, Research Center for Experimental Modeling of Human Disease Professor
- 2015/06 - 2021/03 Kanazawa University Advanced Science Research Center
- 2011/09 - 2015/06 Cincinnati Children’s Hospital Medical Center, USA Division of Reproductive Sciences Research Associate Professor
- 2008/05 - 2011/08 Cincinnati Children’s Hospital Medical Center, USA Division of Reproductive Sciences Research Assistant Professor
- 2004/03 - 2008/05 Vanderbilt University Medical Center, USA Department of Pediatrics Research Assistant Professor
- 2002/07 - 2004/02 Vanderbilt University Medical Center, USA Department of Pediatrics Postdoctoral Fellow
- 2001/09 - 2002/06 University of Kansas Medical Center, USA Department of Molecular and Integrative Postdoctoral Fellow
- 2000/04 - 2001/09 University of Kansas Medical Center, USA Department of Biochemistry Postdoctoral Fellow
Show all
Committee career (3):
- 2016 - 現在 北陸生殖医学会 評議員
- 2015 - 現在 北陸実験動物研究会 役員
- 2018 - 2020 国立大学法人動物実験施設協議会 調査委員会委員
Association Membership(s) (4):
北陸生殖医学会
, 国立大学法人動物実験施設協議会
, 北陸実験動物研究会
, American Association for Cancer Research
Return to Previous Page