Rchr
J-GLOBAL ID：201801000414578401   Update date: May. 11, 2024

Fujimoto Mitsuaki

フジモト ミツアキ | Fujimoto Mitsuaki
Affiliation and department：
Yamaguchi University

About Yamaguchi University


Homepage URL  (1)： http://ds22.cc.yamaguchi-u.ac.jp/~seika2/
Research field  (1)： Molecular biology
Research keywords  (8)： Heat shock factor ,  Cancer ,  Proteostasis ,  転写 ,  Heat shock protein ,  Molecular biology ,  生化学 ,  医化学
Research theme for competitive and other funds  (24)：
  • 2019 - 2022 Mechanism of gene expression via epigenetic regulation by HSF1 complex
  • 2018 - 2021 Analysis of regulatory mechanisms of proteostasis by novel HSF1 transcription complexes
  • 2019 - 2020 HSF1複合体によるエピジェネティックな遺伝子発現制御
  • 2016 - 2019 Transcriptional regulation and DNA repair mechanism of HSF1-PARP complex by DNA damage stimulation
  • 2015 - 2018 Molecular basis for the development of anti-tumor therapy by targeting HSF1.
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Papers (60)：
  • Mitsuaki Fujimoto, Ryosuke Takii, Akira Nakai. Regulation of HSF1 transcriptional complexes under proteotoxic stress: Mechanisms of heat shock gene transcription involve the stress-induced HSF1 complex formation, changes in chromatin states, and formation of phase-separated condensates: Mechanisms of heat shock gene transcription involve the stress-induced HSF1 complex formation, changes in chromatin states, and formation of phase-separated condensates. BioEssays : news and reviews in molecular, cellular and developmental biology. 2023. 45. 7. e2300036
  • Mariko Okada, Mitsuaki Fujimoto, Pratibha Srivastava, Akanksha Pandey, Ryosuke Takii, Akira Nakai. The Mediator subunit MED12 promotes formation of HSF1 condensates on heat shock response element arrays in heat-shocked cells. FEBS letters. 2023
  • Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Nature Communications. 2022. 13. 1. 4355-4355
  • Masanori Tabara, Koji Shiraishi, Ryosuke Takii, Mitsuaki Fujimoto, Akira Nakai, Hideyasu Matsuyama. Testicular localization of activating transcription factor 1 and its potential function during spermatogenesis. Biology of Reproduction. 2021. 105. 4. 976-986
  • Pratibha Srivastava, Ryosuke Takii, Mariko Okada, Mitsuaki Fujimoto, Akira Nakai. MED12 interacts with the heat-shock transcription factor HSF1 and recruits CDK8 to promote the heat-shock response in mammalian cells. FEBS Letters. 2021. 595. 14. 1933-1948
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MISC (18)：
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Patents (1)：
  • HSF1とRPA1との相互作用阻害ペプチド
Books (3)：
  • Heat Shock Factor.
    Springer, Japan 2016
  • ベーシック生化学
    化学同人 2009
  • キーワードで理解する転写イラストマップ
    羊土社 2004
Lectures and oral presentations  (75)：
  • Analysis of droplet formation of the heat shock transcription factor HSF1
    (2021)
  • Evolution of the heat shock transcription factor genes HSF1 and HSF3 in vertebrates
    (2021)
  • 液相分離を介したHSF1転写複合体の解析
    (第15回 日本臨床ストレス応答学会大会 2021)
  • HSF1-TRRAP複合体よるエピゲノムとプロテオスタシス容量の制御
    (第15回 日本臨床ストレス応答学会大会 2021)
  • Phosphorylation of HSF1 facilitates establishment of active chromatin states and maintains proteostasis in cancer cells
    (2021)
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Education (3)：
  • 1997 - 2000 Hokkaido University
  • 1995 - 1997 Hokkaido University Graduate School, Division of Pharmaceutical Sciences
  • 1991 - 1994 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
Professional career (1)：
  • 博士(薬学) (北海道大学)
Work history (6)：
  • 2013/10 - 現在 Yamaguchi University of Medicine, Graduate School
  • 2010/05 - 2013/09 Yamaguchi University of Medicine, Graduate School
  • 2005/04 - 2006/03 Yamaguchi University School of Medicine, Faculty of Medicine
  • 2002/10 - 2005/03 Yamaguchi University School of Medicine, Faculty of Medicine
  • 2001/04 - 2002/09 米国 エモリー大学 ポスドク
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Awards (2)：
  • 2013/07 - FEBS Journal FEBS Journal Top-Cited Paper Award
  • 2006/02 - 山口大学 医学会 中村賞
Association Membership(s) (3)：
The Biomedical Society for Stress Response ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE BIOCHEMICAL SOCIETY
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