Yasuda Takahiko

Affiliation and department：

Research field (2)： Tumor biology , Hematology and oncology

Research keywords (5)： AYA , RNA-seq , fusion gene , oncogene , acute lymphoblastic leukemia

Research theme for competitive and other funds (8)：

2022 - 2026 隠れドライバーから見た、難治性リンパ性白血病の成立・維持機構の解明
2022 - 2025 日本人に特徴的な白血病原性融合遺伝子の白血病発症機構の解明
2021 - 2025 悪性リンパ腫疑い不明熱患者に対するリキッドバイオプシーによる診断法の確立
2021 - 2024 Evaluation of minimal residual disease by liquid biopsy in malignant lymphoma for precise therapeutic stratification.
2021 - 2024 成人B細胞性急性リンパ性白血病における新規サブタイプ同定とその分子病態の解明

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Papers (46)：

Mina Noura, Hidemasa Matsuo, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa. Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia. Oncogene. 2023
Mina Noura, Takahiko Yasuda, Shinobu Tsuzuki, Hidemasa Matsuo, Hitoshi Kiyoi, Fumihiko Hayakawa. Suppression of Super-Enhancer-Driven TAL1 Expression By KLF4 in T-Cell Acute Lymphoblastic Leukemia. Blood. 2023. 142. Supplement 1. 1405-1405
Koya Odaira, Takahiko Yasuda, Kentaro Okada, Takuya Shimooka, Yukino Kojima, Mina Noura, Shogo Tamura, Shingo Kurahashi, Eisuke Iwamoto, Masashi Sanada, et al. Functional inhibition of MEF2 by C/EBP is a possible mechanism of leukemia development by CEBP-IGH fusion gene. Cancer science. 2022. 114. 3. 781-792
Takahiko Yasuda, Masashi Sanada, Shinobu Tsuzuki, Fumihiko Hayakawa. Oncogenic lesions and molecular subtypes in adults with B-cell acute lymphoblastic leukemia. Cancer science. 2022
Shinobu Tsuzuki, Takahiko Yasuda, Hiroaki Goto, Naoko Maeda, Koshi Akahane, Takeshi Inukai, Hideyuki Yamamoto, Sivasundaram Karnan, Akinobu Ota, Toshinori Hyodo, et al. BCL6 inhibition ameliorates ruxolitinib resistance in CRLF2-rearranged acute lymphoblastic leukemia. Haematologica. 2022

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MISC (15)：

Molecular pathology underlying leukemia of adolescents and young adults. BIO Clinica. 2022. 37. 3. 26-30
Shinobu Tsuzuki, Takahiko Yasuda, Masahito Kawazu, Toshihide Ueno, Sivasundaram Karnan, Akinobu Ota, Masashi Sanada, Hirokazu Nagai, Akihiro Tomita, Yoshiyuki Takahashi, et al. Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia. CANCER SCIENCE. 2022. 113. 1236-1236
安田貴彦. AYA・成人B細胞性急性リンパ性白血病の分子基盤の最前線. 医学のあゆみ. 2022. 280. 1. 27-34
安田貴彦. AYA世代急性リンパ性白血病の特徴. 血液内科. 2021. 82. 4. 512-517
齋藤俊樹, 濱野康司, 山本松雄, 安田貴彦, 近藤修平, 真田昌, 永井宏和, 堀部敬三. がん領域におけるクリニカルシーケンスのための臨床ゲノム情報データベースの開発. 日本癌治療学会学術集会抄録集. 2019. 57回. O35-1

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Patents (1)：

Books (3)：

Lectures and oral presentations (11)：

AYA世代のがん研究における最新の知見 Pre-B細胞性急性リンパ球性白血病における転写制御ネットワーク
(日本癌学会総会記事 2021)
Genomic and Clinical Characterization of Adult Ph-Negative B-Cell Acute Lymphoblastic Leukemia
(BLOOD 2018)
成人B細胞性急性リンパ性白血病のゲノム学的・臨床的な特徴(Genomic and clinical characterization of adult B-cell acute lymphoblastic leukemia)
(臨床血液 2018)
ZNF384融合遺伝子による急性リンパ性白血病発症機構の解明(Molecular mechanisms of B acute lymphoblastic leukemia development by ZNF384-fusion proteins)
(臨床血液 2018)
The Attempt to Identify Suitable MRD Markers in Acute Lymphoblastic Leukemia by next - Generation Sequencing for Practical Use
(PEDIATRIC BLOOD & CANCER 2017)

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Education (2)：

Professional career (1)：

Work history (7)：

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Awards (2)：

Association Membership(s) (2)：

日本癌学会 , 日本血液学会

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