Kunimoto Hiroyoshi

クニモトヒロヨシ | Kunimoto Hiroyoshi

Affiliation and department：
Job title： Lecturer
Homepage URL (1)： http://www.ycuhri.com/

Research field (1)： Hematology and oncology

Research keywords (3)：骨髄異形成症候群 , 白血病 , エピジェネティクス

Research theme for competitive and other funds (3)：

2021 - 2024 Investigating molecular basis of chemoresistance using a novel leukemia cell line harboring high-risk chromosome abnormalities
2020 - 2023 ミトコンドリアダイナミックスによる白血病幹細胞制御機構の解明と新規治療への応用
2019 - 2021 Investigating a novel therapeutic strategy for preleukemic clonal hematopoiesis based on proinflammatory cytokine-mediated cell extrinsic mechanism of clonal expansion

Papers (25)：

Takuma Ohashi, Hiroyoshi Kunimoto, Jun Nukui, Haruka Teshigawara, Satoshi Koyama, Takuya Miyazaki, Maki Hagihara, Kenji Matsumoto, Eriko Koshimizu, Naomi Tsuchida, et al. A case of Bloom syndrome manifesting with therapy-related myelodysplastic syndromes harboring a novel BLM gene variant. International Journal of Hematology. 2024
Katherine Knorr, Jahan Rahman, Caroline Erickson, Eric Wang, Mara Monetti, Zhuoning Li, Juliana Ortiz-Pacheco, Andrew Jones, Sydney X. Lu, Robert F. Stanley, et al. Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia. Nature Cancer. 2023
Shunsuke Soma, Koichi Murakami, Yumi Fukuchi, Hiroyoshi Kunimoto, Hideaki Nakajima. O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation. Stem Cells. 2023
Hiroyoshi Kunimoto, Ayaka Miura, Ayaka Maeda, Naomi Tsuchida, Yuri Uchiyama, Yosuke Kunishita, Yuki Nakajima, Kaoru Takase-Minegishi, Ryusuke Yoshimi, Takuya Miyazaki, et al. Clinical and genetic features of Japanese cases of MDS associated with VEXAS syndrome. International journal of hematology. 2023
Takuma Ohashi, Kaoru Takase-Minegishi, Ayaka Maeda, Naoki Hamada, Ryusuke Yoshimi, Yohei Kirino, Hiroshi Teranaka, Hiroyoshi Kunimoto, Maki Hagihara, Kenji Matsumoto, et al. Incidence and Risk of Hematological Adverse Events Associated With Immune Checkpoint Inhibitors: A Systematic Literature Review and Meta-Analysis. Journal of hematology. 2023. 12. 2. 66-74

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MISC (8)：

國本博義, 福地由美, 村上紘一, 池田順治, 寺中寛, 加藤生真, 宮崎拓也, 江中牧子, 三ツ橋雄之, 山崎悦子, et al. 3番染色体転座と7番染色体欠失を有する高リスクMDS/AMLからの細胞株と異種移植モデルの樹立. 日本血液学会学術集会抄録(Web). 2020. 82nd
Koichi Murakami, Daisuke Kurotaki, Wataru Kawase, Shunsuke Soma, Yumi Fukuchi, Hiroyoshi Kunimoto, Ryusuke Yoshimi, Shuhei Koide, Motohiko Oshima, Takako Hishiki, et al. Regulation of Mitophagy By O-Linked N-Acetylglucosamine Transferase Is Essential for Hematopoietic Stem Cell Maintenance. BLOOD. 2018. 132
村上紘一, 黒滝大翼, 川瀬航, 相馬俊介, 福地由美, 國本博義, 吉見竜介, 小出周平, 大島基彦, 小田真由美, et al. O-GlcNAc化による造血幹細胞ミトコンドリアダイナミクスの制御(O-GlcNAcylation is critical for mitochondrial dynamics in hematopoietic stem cells). 臨床血液. 2018. 59. 9. 1483-1483
Hiroyoshi Kunimoto, Yumi Fukuchi, Masatoshi Sakurai, Daichi Abe, Ken Sadahira, Yasuo Ikeda, Shinichiro Okamoto, Hideaki Nakajima. Tet2 Uniquely Regulates Self-Renewal and Long Term Repopulating Capacity of Fetal Liver and Bone Marrow Hematopoietic Stem Cells. BLOOD. 2012. 120. 21
Masatoshi Sakurai, Hiroyoshi Kunimoto, Naohide Watanabe, Yumi Fukuchi, Ken Sadahira, Shinsuke Yuasa, Keiichi Fukuda, Satoshi Yamazaki, Hiromitsu Nakauchi, Yasuhiro Ebihara, et al. Impaired Hematopoietic Differentiation of iPSCs Derived From Patients with FPD/AML. BLOOD. 2012. 120. 21

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Education (2)：

2009 - 2013 Keio University
1999 - 2005 Keio University School of Medicine Depertment of Medicine

Professional career (1)：

博士(医学) (慶應義塾大学)

Work history (6)：

2024/04 - 現在 Yokohama City University Graduate School of Medicine Department of Hematology and Clinical Immunology Senior Lecturer
2018/04 - 2024/03 Yokohama City University Graduate School of Medicine
2014/04 - 2018/03 Memorial Sloan Kettering Cancer Center
2009/04 - 2014/03 Keio University School of Medicine, Department of Internal Medicine
2007/04 - 2009/03 Keio University School of Medicine, Department of Internal Medicine

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Awards (6)：

2021 - 日本白血病研究基金研究賞
2021 - American Society of Hematology Award Supplement
2019 - American Society of Hematology Global Research Award
2019 - 横浜市立大学医学研究奨励賞
2016/12 - 米国血液学会抄録奨励賞

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Association Membership(s) (5)：

American Society of Hematology , 日本臨床腫瘍学会 , THE JAPANESE CANCER ASSOCIATION , THE JAPANESE SOCIETY OF HEMATOLOGY , THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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