Hata Tatsuo

ハタタツオ | Hata Tatsuo

Affiliation and department：

Research field (3)： Genomics , Tumor biology , Digestive surgery

Research keywords (10)：内視鏡外科 , がんゲノム医療 , バイオマーカー , 胆嚢癌 , 肝癌 , 胆管癌 , リキッドバイオプシー , 膵癌 , 肝胆膵外科 , 消化器外科

Research theme for competitive and other funds (14)：

2022 - 2025 人工知能を用いた医用画像と膵液バイオマーカーの統合解析による小膵癌診断技法の構築
2020 - 2023 膵・胆道癌における染色体不安定性を標的とした革新的診断・免疫治療法の開発
2019 - 2022 Development of diagnostic technique of pancreatic cancer by using liquid biopsy targeted DNA methylation markers
2019 - 2022 膵・消化管神経内分泌腫瘍におけるCNPY2の肝転移関連機序の解明
2019 - 2022 分子署名に基づいた血中循環腫瘍細胞の細分類化と膵癌集学的治療の精密化への臨床応用

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Papers (145)：

Tatsuo HataMasamichi MizumaTakashi KusakabeHodaka AmanoToru, FurukawaToshiyasu IwaoMichiaki Unno. Simultaneous and sequential combination of genetic and epigenetic biomarkers for the presence of high-grade dysplasia in patients with pancreatic cyst: Discovery in cyst fluid and test in pancreatic juice. Pancreatology. 2023. 23. 2. 218-226
Tatsuo Hata, Kazuharu Chiba, Masamichi Mizuma, Kunihiro Masuda, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Hiroki Hayashi, Fuyuhiko Motoi, Michiaki Unno. Levels of tumor markers CEA/CA 19-9 in serum and peritoneal lavage predict postoperative recurrence in patients with pancreatic cancer. Annals of Gastroenterological Surgery. 2022. 6. 6. 862-872
Kazuharu Chiba, Tatsuo Hata, Masamichi Mizuma, Kunihiro Masuda, Shuichi Aoki, Tatsuyuki Takadate, Kei Kawaguchi, Kei Nakagawa, Takanori Morikawa, Fuyuhiko Motoi, et al. Impact of Tumor-Derived DNA Testing in Peritoneal Lavage of Pancreatic Cancer Patients with and Without Occult Intra-Abdominal Metastases. Annals of Surgical Oncology. 2022. 29. 4. 2685-2697
Tatsuo Hata, Masamichi Mizuma, Fuyuhiko Motoi, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Michiaki Unno. Prognostic impact of postoperative circulating tumor DNA as a molecular minimal residual disease marker in patients with pancreatic cancer undergoing surgical resection. Journal of hepato-biliary-pancreatic sciences. 2022. DOI: 10.1002/jhbp.1282
Tatsuo Hata, Masamichi Mizuma, Fuyuhiko Motoi, Masaharu Ishida, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Toru Furukawa, Michiaki Unno. Germline DNA damage repair gene mutations in pancreatic cancer patients with personal/family histories of pancreas/ breast/ovarian/prostate cancer in a Japanese population. Annals of Gastroenterological Surgery. 2021. 5. 6. 853-864

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MISC (121)：

畠達夫, 水間正道, 海野倫明. 【新・外科感染症診療ハンドブック】膵頭十二指腸切除後の感染性合併症対策. 臨床外科. 2022. 77. 13. 1475-1480
畠達夫, 水間正道, 大森優子, 古川徹, 海野倫明. 【肝胆膵疾患おけるバイオマーカーの意義を探る】IPMNのctDNA解析とバイオマーカーとしての意義. 肝胆膵. 2021. 84. 4. 625-630
川口桂, 青木修一, 畠達夫, 伊関雅裕, 高館達之, 前田晋平, 石田晶玄, 水間正道, 中川圭, 元井冬彦, et al. メチオニンを標的とした膵癌化学療法における新規栄養療法戦略の可能性. 学会誌JSPEN. 2020. 2. Suppl.1. 247-247
元井冬彦, 青木修一, 畠達夫, 伊関雅裕, 高舘達之, 前田晋平, 有明恭平, 川口桂, 石田晶玄, 水間正道, et al. 膵癌切除術後合併症の重症度と周術期栄養状態の関連. 学会誌JSPEN. 2020. 2. Suppl.1. 326-326
石田晶玄, 元井冬彦, 青木修一, 畠達夫, 伊関雅裕, 高舘達之, 前田晋平, 有明恭平, 川口桂, 水間正道, et al. 膵臓手術後の膵外分泌機能検査(PFD試験)は、術後の長期栄養状態の指標となるか. 学会誌JSPEN. 2020. 2. Suppl.1. 1025-1025

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Lectures and oral presentations (71)：

Usefulness of genome/epigenome markers in pancreatic juice to detect high-grade dysplastic lesions.
(2022)
Impact of genome/epigenome biomarker testing using serially harvested pancreatic juice samples in patients with IPMN
(Joint Congress of the 26th Meeting of International Association of Pancreatology (IAP) and the 53th Annual Meeting of Japan Pancreas Society (JPS)(シンポジウム)) 2022)
Prognostic impact of postoperative circulating tumor DNA as a molecular residual disease marker in patients with pancreatic cancer undergoing surgical resection
(第34回日本肝胆膵外科学会学術集会(プレナリーセッション) 2022)
連続膵液細胞診と膵液中のKRAS/GNAS遺伝子変異測定を併用した膵病変の診断・リスク評価の有用性
(第108回日本消化器病学会総会(ワークショップ) 2022)
膵病変の診断・リスク評価における連続膵液細胞診と膵液中のKRAS/GNAS遺伝子測定の有用性
(第122回日本外科学会定期学術集会 2022)

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Education (2)：

2012 - 2016 Tohoku University Graduate School of Medicine
1999 - 2005 Tohoku University Faculty of Medicine School of Medicine

Professional career (1)：

博士(医学) (東北大学)

Work history (2)：

2017/04 - 現在東北大学大学院医学系研究科消化器外科学分野非常勤講師
2015/04 - 2017/03 Johns Hopkins Medical Insutitutions Department of pathology Research fellow

Awards (8)：

2022/06 - 日本肝胆膵外科学会理事長賞
2020/02 - 日本肝胆膵外科学会理事長賞
2018 - 日本消化器外科学会学会賞(JSGS Young Investigator of the Year 2018)
2017 - 日本癌治療学会優秀演題賞
2016 - 18th Annual Department of Pathology Young Investigators

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Association Membership(s) (11)：

JAPAN BILIARY ASSOCIATION , JAPAN PANCREAS SOCIETY , 日本内視鏡外科学会 , JAPAN SOCIETY OF CLINICAL ONCOLOGY , THE JAPANESE CANCER ASSOCIATION , JAPANESE SOCIETY OF HEPATO-BILIARY-PANCREATIC SURGERY , JAPANESE SOCIETY OF GASTROENTEROLOGY , THE JAPANESE SOCIETY OF GASTROENTEROLOGICAL SURGERY , JAPAN SURGICAL SOCIETY , 日本臨床栄養代謝学会 , 日本肝臓学会

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