Rchr
J-GLOBAL ID：201801000587766947   Update date: May. 15, 2024

SATOSHI KOFUJI

コフジ サトシ | SATOSHI KOFUJI
Affiliation and department：
東京医科歯科大学 難治疾患研究所

About 東京医科歯科大学 難治疾患研究所


Job title： 講師
Research field  (1)： Molecular biology
Research theme for competitive and other funds  (9)：
  • 2021 - 2024 加齢依存的脂肪性肝疾患の病態と分子機序の解明
  • 2020 - 2023 Elucidation of the roles of the Hippo-YAP signaling pathway in regulating cell tension in liver development and regeneration
  • 2018 - 2021 脳腫瘍における GTP 代謝スイッチの分子機構と意義の解明
  • 2014 - 2017 The role of myotubularins in pathogenesis of microscopic polyangiitis.
  • 2015 - 2016 GTPエネルギー代謝に着目した癌検査及び治療技術の開発
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Papers (42)：
  • Satoshi Kofuji, Kara Wolfe, Kazutaka Sumita, Shun Kageyama, Hirofumi Yoshino, Yoshihisa Hirota, Aki Ogawa-Iio, Hirotaka Kanoh, Mika Sasaki, Kaori Kofuji, et al. A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion. Biochemical and biophysical research communications. 2024. 718. 149981-149981
  • Jing Pu, Satoshi Kofuji, Yoshimi Okamoto-Uchida, Keiko Danzaki, Ruoxing Yu, Akira Suzuki, Satoshi Kitajima, Hiroshi Nishina. Lethal Phenotype-Based Database Screening Identifies Ceramide as a Negative Regulator of Primitive Streak Formation. Stem Cells. 2023
  • Yoshiki Ikeda, Mindy I Davis, Kazutaka Sumita, Yuxiang Zheng, Satoshi Kofuji, Mika Sasaki, Yoshihisa Hirota, Rajan Pragani, Min Shen, Matthew B Boxer, et al. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and biophysical research communications. 2023. 679. 116-121
  • Hajime Tajima Sakurai, Hidefumi Iwashita, Satoko Arakawa, Alifu Yikelamu, Mizuki Kusaba, Satoshi Kofuji, Hiroshi Nishina, Munetaka Ishiyama, Yuichiro Ueno, Shigeomi Shimizu. Development of small fluorescent probes for the analysis of autophagy kinetics. iScience. 2023. 26. 7. 107218-107218
  • Chiyumi Oda, Kenya Kamimura, Osamu Shibata, Shinichi Morita, Yuto Tanaka, Toru Setsu, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, et al. HBx and YAP expression could promote tumor development and progression in HBV-related hepatocellular carcinoma. Biochemistry and biophysics reports. 2022. 32. 101352-101352
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MISC (24)：
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Lectures and oral presentations  (42)：
  • 低分子化合物による細胞死を誘導する液胞形成
    (第43回日本分子生物学会年会 2020)
  • 物質代謝異常によるがん発症機構の解明
    (第1回 細胞死コロキアム 2020)
  • グアニンヌクレオチド代謝リプログラミングが 制御する腫瘍形成のメカニズム
    (第93回日本生化学会大会 2020)
  • MKK7-JNK シグナル伝達経路は育仔行動に必須である
    (第 19 回次世代を担う若手のためのファーマ・バイオフォーラム 2020 2020)
  • 脳腫瘍における核小体の活性化制御とGTP代謝リプログラミング
    (第140年会日本薬学会 2020)
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Professional career (1)：
  • 博士(薬学) (東京大学)
Work history (8)：
  • 2019/12 - 現在 Tokyo Medical and Dental University
  • 2017/06 - 2019/11 Hiroshima University
  • 2014/04 - 2017/05 University of Cincinnati, OH, USA Postdoctoral Fellow
  • 2013/12 - 2014/03 Akita University
  • 2012/04 - 2013/11 Akita University Graduate School of Medicine
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Awards (1)：
  • 2021/04 - United Japanese researchers Around the world UJA Paper Award IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma
Association Membership(s) (3)：
The Japanese Society of Cell Death Research ,  The Pharmaceutical Society of Japan ,  The Molecular Biology Society of Japan
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