Rchr
J-GLOBAL ID：201801000633508516   Update date: Jul. 22, 2024

Mahomi Kuroiwa

クロイワ マホミ | Mahomi Kuroiwa
Homepage URL  (1)： http://www.med.kurume-u.ac.jp/med/pharm/index.html
Research field  (1)： Psychiatry
Research keywords  (8)： Intracellular signaling ,  Dopamine ,  Major depressive disorder ,  Schizophrenia ,  Dentate gyrus ,  Striatum ,  DARPP-32 ,  Phosphorylation
Research theme for competitive and other funds  (17)：
  • 2023 - 2027 Enhancement of antidepressant responsiveness by stress via reorganization of noradrenergic signaling
  • 2023 - 2026 アセチルコリン/ドパミン神経回路を標的としたうつ病の新規治療法の探索
  • 2023 - 2026 抗うつ薬作用増強に必要なドパミン・ノルアドレナリン神経回路機構の解明
  • 2023 - 2026 Development of treatments for post traumatic stress disorder related to surgery and intensive care.
  • 2022 - 2025 Development of novel therapeutics for neuropsychiatric disorders targeting dopamine signaling
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Papers (32)：
  • 西 昭徳, 杉山 慶太, 黒岩 真帆美. 大脳基底核研究の最前線-機能と障害の脳基盤- 線条体の領域特異的なD1受容体シグナル L-ドパ誘発性ジスキネジアにおける役割. 日本神経精神薬理学会年会プログラム・抄録集. 2023. 53回. 74-74
  • Ryusuke Sin, Naoki Sotogaku, Yoshinori N. Ohnishi, Takahide Shuto, Mahomi Kuroiwa, Yukie Kawahara, Keita Sugiyama, Yuki Murakami, Masaaki Kanai, Hiroshi Funakoshi, et al. Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments. Brain, Behavior, and Immunity. 2023
  • Mahomi Kuroiwa, Takahide Shuto, Taku Nagai, Mutsuki Amano, Kozo Kaibuchi, Angus C Nairn, Akinori Nishi. DARPP-32/protein phosphatase 1 regulates Rasgrp2 as a novel component of dopamine D1 receptor signaling in striatum. Neurochemistry international. 2023. 162. 105438-105438
  • Hideo Hagihara, Hirotaka Shoji, Mahomi Kuroiwa, Isabella A Graef, Gerald R Crabtree, Akinori Nishi, Tsuyoshi Miyakawa. Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice. Molecular brain. 2022. 15. 1. 94-94
  • Katsunori Kobayashi, Kisako Shikano, Mahomi Kuroiwa, Mio Horikawa, Wakana Ito, Akinori Nishi, Eri Segi-Nishida, Hidenori Suzuki. Noradrenaline activation of hippocampal dopamine D1 receptors promotes antidepressant effects. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 33. e2117903119
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MISC (37)：
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Education (3)：
  • 2004 - 2008 Kurume University School of Medicine Department of Pharmacology
  • 2002 - 2004 Kyushu University Faculty of Pharmaceutical Sciences Department of Pharmacology
  • 1996 - 2000 Nagasaki University Faculty of Pharmaceutical Sciences
Professional career (1)：
  • 博士(医学) (久留米大学)
Work history (1)：
  • 2009/01 - 現在 Kurume University School of Medicine Department of Pharmacology Research associate
Committee career (1)：
  • 2019/04 - 現在 日本薬理学会 学術評議員
Awards (2)：
  • 2009/03 - 久留米大学 久留米大学学術奨励賞 Regulation of DARPP-32 phosphorylation by three distinct dopamine D1-like receptor signaling pathways in the neostriatum.
  • 2006/06 - 日本脳科学会 日本脳科学会奨励賞 ドーパミン D1 様受容体を介するホスホリパーゼC依存性および非依存性 DARPP-32 リン酸化調節
Association Membership(s) (5)：
The Japanese Society of Clinical Pharmacology and Therapeutics ,  THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY ,  THE JAPAN NEUROSCIENCE SOCIETY ,  THE JAPANESE PHARMACOLOGICAL SOCIETY ,  Society for Neuroscience
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