Kawabe Takeshi

カワベタケシ | Kawabe Takeshi

Affiliation and department：
Job title：准教授

Research field (1)： Immunology

Research keywords (3)：感染免疫 , 自己免疫・炎症性疾患 , T細胞

Research theme for competitive and other funds (7)：

2023 - 2025 T細胞ホメオスタシスにおける自己反応性の新たな意義
2022 - 2025 新たな自己反応性T細胞の恒常性維持機構ならびに生理的・病理的意義の解明
2022 - 2024 T細胞の自然免疫機能に立脚した新たな感染症治療戦略の創出
2021 - 2024 Revealing immune cell network formed by novel self-reactive T lymphocytes
2020 - 2023 TNF受容体型補助刺激分子による自然リンパ球の制御機構

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Papers (28)：

Kawabe T. Homeostasis and immunological function of self-driven memory-phenotype CD4+ T lymphocytes. Immunol Med. 2023. 46. 1. 1-8
Okuyama Y, Okajima A, Sakamoto N, Hashimoto A, Tanabe R, Kawajiri A, Kawabe T, Ishii N. IL-33-ILC2 axis promotes anti-tumor CD8+ T cell responses via OX40 signaling. Biochem Biophys Res Commun. 2022. 637. 9-16
Terui H, Yamasaki K, Wada-Irimada M, Onodera-Amagai M, Hatchome N, Mizuashi M, Yamashita R, Kawabe T, Ishii N, Abe T, et al. Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis. Sci Immunol. 2022. 7. 76. eabm9811
Kawabe T. Memory-phenotype CD4+ T Lymphocytes: A Novel Therapeutic Target in Infectious or Autoimmune Diseases?. JMA J. 2022. 5. 3. 298-306
Kawabe T, Ciucci T, Kim KS, Tayama S, Kawajiri A, Suzuki T, Tanaka R, Ishii N, Jankovic D, Zhu J, et al. Redefining the Foreign Antigen and Self-Driven Memory CD4+ T-Cell Compartments via Transcriptomic, Phenotypic, and Functional Analyses. Front Immunol. 2022. 13. 870542

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MISC (17)：

Kawabe T, Ciucci T, Kim KS, Yang Z, Kawajiri A, Tayama S, Ishii N, Jankovic D, Zhu J, Sprent J, et al. CD127 and Sca1 mark self-driven memory-phenotype CD4 +T cells that differ from foreign antigen-specific memory cells and possess inflammatogenic and anti-tumor activities. J Immunol. 2023. 210. S1. 76.08
Kawajiri A, Li J, Yang Z, Koinuma K, Yoon HJ, Ishii M, Tayama S, Sato K, Okuyama Y, Harigae H, et al. Self antigen-driven, undifferentiated memory-phenotype CD4 T lymphocytes can induce mild and systemic inflammation by differentiating into effector and regulatory T cells. J Immunol. 2023. 210. S1. 76.09
Tayama S, Kitamura Y, Hiraide K, Li J, Yang Z, Kawajiri A, Sato K, Okuyama Y, Kawabe T, Akaike T, et al. Reactive persulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation. J Immunol. 2023. 210. S1. 61.01
田山舜一, 河部剛史, 石井直人. 2型自然リンパ球における足場蛋白質IQGAP1の新たな役割. 臨床免疫・アレルギー科. 2020. 74. 3. 226-233
Tayama S, Okuyama Y, Phung HT, Asao A, Kobayashi S, Kawabe T, So T, Ishii N. IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s. J Immunol. 2020. 204. S1. 147.4

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Books (2)：

Lectures and oral presentations (73)：

Self-driven memory-phenotype cells: a naturally arising CD4+ T lymphocyte population possessing innate immune function
(The RIKEN IMS-JSI International Symposium on Immunology 2023 2023)
Reactive persulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation
(Annual Meeting of The American Association of Immunologists 2023 2023)
CD127 and Sca1 mark self-driven memory-phenotype CD4+ T cells that differ from foreign antigen-specific memory cells and possess inflammatogenic and anti-tumor activities
(Annual Meeting of The American Association of Immunologists 2023 2023)
Self antigen-driven, undifferentiated memory-phenotype CD4+ T lymphocytes can induce mild and systemic inflammation by differentiating into effector and regulatory T cells
(Annual Meeting of The American Association of Immunologists 2023 2023)
新規の自然免疫型T細胞の機能制御による新たな感染症治療戦略の創出
(第6回先進医薬研究報告会 2022)

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Education (2)：

Professional career (1)：

Work history (6)：

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Awards (17)：

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Association Membership(s) (2)：

International Cytokine and Interferon Society , 日本免疫学会

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