Rchr

J-GLOBAL ID：201801000825629171 Update date: Feb. 07, 2025

Isaka Yoshitaka

イサカヨシタカ | Isaka Yoshitaka

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://www.med.osaka-u.ac.jp/pub/kid/kid/index.html

Research field (1)： Nephrology

Research theme for competitive and other funds (51)：

2024 - 2027 Exploration of aging tubule-inducing factors and their pathophysiology for the development of therapeutic agents for diabetic kidney disease
2024 - 2027 Seeds Search for Preventing AKI in the Elderly Focusing on AKI Vulnerability
2023 - 2026 Elucidation of the mechanism for progression of tubulointerstitial fibrosis induced by glomerular injury
2022 - 2025 Dapagliflozin preserves allograft function in kidney transplant recipients (KTRs).
2022 - 2025 血液/尿中キラルアミノ酸の網羅的定量を基盤とする腎不全の早期低侵襲診断鑑別法開発

2021 - 2025 IoT機器を活用した在宅腎臓リハビリテーションの遠隔支援システムの構築

2021 - 2024 早期CKD患者の精密医療を目指した予後評価法の開発

2021 - 2024 転写因子Mondoによる腎近位尿細管オートファジー・エネルギー代謝制御機構の解明

2021 - 2024 molecular genetic analyses of a family with hereditary hypo Mg, hypo K ,and hypertension

2021 - 2024 COVID-19感染症患者に対するSARS-catchカラムに関する研究開発

2019 - 2023 The importance of peer-to-peer networking in the community-based integrated care systems

2019 - 2022 Development of the three-dimensional LC system to realize quantitative chiral metabolomics for early diagnosis of kidney/heart disfunctions

2019 - 2022 Lipophagy in AKI: the role and clinical application

2019 - 2022 Estimation of renal outcome in kidney donors with renal biopsy

2021 - SARS-CoV-2吸着カラムの開発

2019 - 2021 Elucidation of renal disease onset and progression mechanism using single cell RNA-sequence

2018 - 2021 Effects of physical exercise continuation support system in renal rehabilitation

2018 - 2021 Lysosomal stress as an emerging target in kidney disease

2017 - 2020 Development of a new therapy for lifestyle-related CKD targeting autophagy recycling system

2017 - 2019 Potential effect of active vitamin D analogue as an adjuvant therapy for Fabry disease: from the point of autophagy

2016 - 2019 Early and minimally invasive diagnosis of kidney failure using chiral amino acid metabolomics

2016 - 2019 Research on diagnosis, treatment and epidemiology of membrane nephropathy in the Asia-Pacific region

2016 - 2019 Autophagic inhibitor Rubicon in proximal tubules can be a therapeutic target for metabolic syndrome-related kidney disease.

2016 - 2019 a molecular biology study of Autosomal dominant tubulointerstitial kidney disease by using mutated MUC1 cDNA sequence identified in our own patient family.

2017 - 2019 高齢腹膜透析患者の生活活動性を高めるための地域連携システムの構築と普及のための対策

2015 - 2018 Unraveling the Role of Autophagy in Counteracting Lipotoxicity in the Kidney

2015 - 2018 Development of non-invasive bioimaging techniques for evaluation of transplantation related kidney injury.

2015 - 2017 A development of serious game for therapeutic patient education about salt restriction

2014 - 2017 Development of a new therapy by regulating histone acetylation

2014 - 2017 Direct effects of 25-hydroxyvitamin D on renal fibrosis

2014 - 2017 Investigation of effects of daily living and long-term continuing factors on renal rehabilitation

2014 - 2016 The permanent survival of allografts by tolerance induction mediated by the combined therapy of adoptive transfer of Treg cells and the MF-1-gene transfection

2013 - 2016 Basic research of new epigenetic marker, H4K20ac

2012 - 2015 Role of autophagy in kidney aging and metabolic acidosis

2012 - 2015 Investigating a new therapeutic approach from autophagy-deficient associated protein

2012 - 2015 establishment of a new evaluation technique by none envasive MRI

2009 - 2014 Novel approach of induction of donor specific immune tolerance: adoptive transfer of Treg cells combined with MF1 gene transfection

2010 - 2012 The role of autophagy in renal ischemia-reperfusion injury

2009 - 2011 Transplantation of allogenic fetal membrane-derived mesenchymal stem cells protect kidney

2009 - 2011 Therapeutic effect of CD28 superagonist on renal disease via expansion of regulatory T cells

2008 - 2009 慢性移植腎症におけるオートファジーの関与の解明

2008 - 2009 3種抗体、および、レンチウイルスを用いた移植腎生着延長の試み

2007 - 2009 Induction of kidney graft tplerance using donor-specofoc regulatory T cells

2006 - 2007 虚血・低酸素による尿細管傷害ならびに腎発生におけるオートファジーの関与

2005 - 2006 Gene therapy for progressive kidney diseases using siRNA

2005 - 2006 ラット腎移植モデルにおける経口免疫寛容の導入

2003 - 2004 Identification and characterization of stem cells for kidney

2002 - 2002 移植腎の長期生着を目指した遺伝子治療の開発

2001 - 2002 ISOLATION OF STEM CELLS FOR THE KIDNEY AND EXPERIMENTAL TRIAL FOR THE REGENERATIVE MEDICINE

2000 - 2000 エレクトロポレーション法による腎臓への高効率遺伝子導入法の開発

1998 - 2000 Gene therapy for progressive renal diseases

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Papers (797)：

Yosuke Hirakawa, Tomonori Kimura, Shinsuke Sakai, Masayuki Mizui, Masashi Mita, Yoshitaka Isaka, Masaomi Nangaku, Reiko Inagi. Detection of Fast Decliner of Diabetic Kidney Disease Using Chiral Amino Acid Profiling: A Pilot Study. Chemistry & biodiversity. 2025. e202403332
Jun-Ya Kaimori, Jun Matsuda, Asif Jan, Yuki Kawano, Takayuki Kawaoka, Yuta Asahina, Yohei Doi, Tatsufumi Oka, Miho Nagata, Yasuki Ishihara, et al. A Novel Heterozygous and Pathogenic Variant of the HNF1B Gene Associated with Autosomal Dominant Tubulointerstitial Kidney Disease with a Broad Spectrum of Extrarenal Phenotypes: A Case Report. Internal medicine (Tokyo, Japan). 2025
Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Satoshi Minami, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, et al. Age-related TFEB downregulation in proximal tubules causes systemic metabolic disorders and occasional apolipoprotein A4-related amyloidosis. JCI insight. 2024
難波倫子, 高橋篤史, 土井洋平, 平岡敦子, 余西洋明, 酒井晋介, 水井理之, 濱野高行, 猪阪善隆. 腎移植患者におけるSGLT2阻害薬の腎保護効果. 日本臨床腎移植学会雑誌. 2024. 12. 2. 277-283
Maki SHINZAWA, Isao MATSUI, Yohei DOI, Ayumi MATSUMOTO, Atsushi TAKAHASHI, Masaomi NANGAKU, Yoshitaka ISAKA, Masami Ono, Yuriko Yonekura, Yuki Nishizawa, et al. A nationwide questionnaire study evaluated kidney injury associated with Beni-koji tablets in Japan. Kidney International. 2024

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MISC (141)：

山本毅士, 中村隼, 猪阪善隆. Age-Related Decline in TFEB Activity in the Kidney Proximal Tubule Affects Systemic Lipid Metabolism and May Cause Amyloidosis. 日本抗加齢医学会総会プログラム・抄録集. 2024. 24th
中村隼, 山本毅士, 猪阪善隆. 加齢による近位尿細管のTFEB活性低下は全身の脂質代謝を増悪させる. 日本腎臓学会誌(Web). 2024. 66. 6-W
中村隼, 山本毅士, 難波倫子, 高橋篤史, 松田潤, 南聡, 酒井晋介, 前田志穂美, 松井翔, 河合秀亮, et al. 加齢による近位尿細管のTFEB活性低下は,全身の脂質代謝を悪化させ,アミロイドーシスの原因となる. 日本腎臓学会誌(Web). 2024. 66. 4
中村隼, 山本毅士, 猪阪善隆. 最新のADPKDの基礎研究~TFEB-mTOR軸・オートファジーの関与~. 日本腎臓学会誌(Web). 2024. 66. 4
丸山彰一, 神田英一郎, 久米真司, 猪阪善隆, 石倉健司, 臼井丈一, 内田啓子, 岡田浩一, 今田恒夫, 斎藤知栄, et al. エビデンスに基づくCKD診療ガイドライン2023. 日本腎臓学会誌. 2024. 66. 1. i,1-259

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Lectures and oral presentations (8)：

サルコペニア・フレイルを合併した慢性腎臓病患者の栄養管理
(第63回日本内科学会近畿支部生涯教育講演会 2020)
A Randomized Trial of Optimal Phosphate Range for Coronary Artery Calcification in Dialysis Patients
(2020)
Elucidating the Pathophysiology of CKD -Involvement of Autophagy in Kidney Diseases-
(American Society of Nephrology Kidney Week 2020 2020)
血液透析患者の冠動脈石灰化に対する至適リン濃度の検討
(第50回日本腎臓学会西部部会 2020)
Autophagy in CKD
(the 18th Asian Pacific Congress of Nephrology(APCN2020) Symposium:Metabolic Dysregulation and CKD 2020)

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Education (1)：

- 1988 Osaka University Faculty of Medicine

Professional career (1)：

M.D., Ph.D (Osaka University)

Work history (1)：

2015/10 - 現在 Osaka University Graduate School of Medicine

Committee career (5)：

2020 - 現在日本腎臓学会副理事長
2019 - 現在日本移植学会代議員
2019 - 現在日本内科学会評議員
2019 - 現在大阪腎臓バンク常任理事
2018 - 現在日本透析医学会常任理事

Awards (1)：

2008 - 日本腎臓学会大島賞

Association Membership(s) (7)：

日本プライマリケア , 日本臨床腎移植学会 , 日本高血圧学会 , 日本内科学会 , 日本移植学会 , 日本透析医学会 , 日本腎臓学会

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