Tomizawa Minoru

Affiliation and department：

Research field (1)： Gastroenterology

Research theme for competitive and other funds (15)：

2022 - 2025 肝細胞に特異的なCoriサイクルに着目したヒトiPS細胞から肝細胞の分化誘導
2015 - 2018 Differentiation of human induced pluripotent stem cells to hepatocyte lineage
2014 - 生体試料バンクを利用した自己免疫性肝炎の分子生物疫学コホート研究
2014 - C型肝炎ウィルス駆除後の肝炎発症/線維化改善動態評価を目的とした、血清miRNAプロファイリング法の確立
2011 - 2013 Development of transplantation of hepatocytes produced from iPS cells to liver failure

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Papers (103)：

Minoru Tomizawa, Fuminobu Shinozaki, Takashi Mikata, Hiroyuki Tanno, Midori Shigeta. Lactate promotes survival and hepatocyte differentiation of human induced pluripotent stem cells in a medium without glucose and supplemented with galactose. Biomedical Reports. 2023. 19. 6
Kiyoshi Migita, Yoshiro Horai, Hideko Kozuru, Tomohiro Koga, Seigo Abiru, Kazumi Yamasaki, Atsumasa Komori, Yuya Fujita, Tomoyuki Asano, Shuzo Sato, et al. Serum cytokine profiles and Mac-2 binding protein glycosylation isomer (M2BPGi) level in patients with autoimmune hepatitis. Medicine. 2018. 97. 50. e13450
Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige. Oct3/4 is potentially useful for the suppression of the proliferation and motility of hepatocellular carcinoma cells. Oncology letters. 2018. 16. 4. 5243-5248
Shomi Oka, Takashi Higuchi, Hiroshi Furukawa, Minoru Nakamura, Atsumasa Komori, Seigo Abiru, Shinya Nagaoka, Satoru Hashimoto, Atsushi Naganuma, Noriaki Naeshiro, et al. Association of a single nucleotide polymorphism in TNIP1 with type-1 autoimmune hepatitis in the Japanese population. Journal of human genetics. 2018. 63. 6. 739-744
Minoru Tomizawa, Fuminobu Shinozaki, Yoshitaka Uchida, Katsuhiro Uchiyama, Satomi Tanaka, Takafumi Sunaoshi, Daisuke Kano, Eriko Sugiyama, Misaki Shite, Ryouta Haga, et al. Comparison of DWIBS/T2 image fusion and PET/CT for the diagnosis of cancer in the abdominal cavity. Experimental and therapeutic medicine. 2017. 14. 4. 3754-3760

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MISC (16)：

Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige. Signal Intensity of Superb Microvascular Imaging Correlates with the Severity of Acute Cholecystitis. Case Reports in Gastroenterology. 2016. 10. 2. 452-458
Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige. A Case of Gastrointestinal Stromal Tumor That Underwent Endoscopic Ultrasound-Guided Aspiration with a 25-Gauge Biopsy Needle. Case Reports in Gastroenterology. 2016. 10. 1. 173-178
Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige. Duodenal Adenocarcinoma Diagnosed from a Biopsy Specimen of a Depressed Lesion Obtained by Magnifying Endoscopy. Case Reports in Gastroenterology. 2016. 10. 1. 166-172
Tomizawa Minoru, Shinozaki Fuminobu, Fugo Kazunori, Motoyoshi Yasufumi, Sugiyama Takao, Yamamoto Shigenori, Kishimoto Takashi, Ishige Naoki. Diagnosis of gastrointestinal stromal tumor via endoscopic ultrasonography-guided fine needle aspiration. Progress of Digestive Endoscopy. 2016. 89. 1. 94-95
富澤稔. 再生医療 iPS細胞から肝細胞への分化を促進する培地の開発. Pharm stage. 2015. 15. 5. 3-5

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Patents (8)：

Production method for hepatocyte lineage cells, hepatocyte lineage cell or culture product obtained by the production method, and hepatocyte differentiation-inducing medium
Culture medium and method for inducind differentiation of pluripotent stem cells to hepatoblasts
ヒト多能性幹細胞から肝前駆細胞への分化誘導方法
Methods and materials for obtaining hepatocytes lineage cells
胚性幹細胞から肝芽細胞を得る方法

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Books (5)：

Pluripotent stem cells-from bench to clinics
InTech 2016
Biotechnology, Vol 8, Novel Drug Delivery
Studium Press 2014
Pluripotent stem cell biology
InTech 2014
Pluripotent stem cells
InTech 2013
Gene Therapy
Springer 1998

Lectures and oral presentations (19)：

Initiation of human induced pluripotent stem cells to hepatocye-lineage with introduction of liver-specific transfection factors
(16th Annual Meeting of International Society of Stem Cell Research 2018)
Transcription factors and medium suitable for initiating the differentiation of human induced pluripotent stem cells to the hepatocyte lineage.
(15th Annual Meeting of International Society of Stem Cell Research 2017)
A high liver signal in diffusion-weighted whole body imaging with background body signal suppression/T2 image fusion and elevated blood urea nitrogen are associated with percutaneous transhepatic gallbladder drainage.
(Asian Pacific Digestive Week 2016 2016)
Human induced pluripotent stem cells survived and initiated hepatocyte differentiation in William’s E medium followed by hepatocyte differentiation inducer
(14th Annual Meeting of International Society of Stem Cell Research 2016)
Autoimmune hepatitis patients positive for anti-mitochondrial M2 antibody
(25th Conference of the Asian Pacific Association for the Study of the Liver 2016)

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Education (1)：

1981 - 1987 Chiba University School of Medicine

Work history (9)：

2009/04 - 現在独立行政法人国立病院機構下志津病院消化器内科
2004/04 - 2009/03 千葉大学医学部付属病院消化器内科
1999/04 - 2004/03 Chiba University
1998/04 - 1999/03 National Institute of Diabetes and Digestive and Kidney Diseases Molecular and Endocrinology Branch
1996/04 - 1998/03 National Human Genome Research Institute, National Institutes of Health Clinical Gene Therapy Branch

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Association Membership(s) (11)：

日本再生医療学会 , 日本癌学会 , 日本消化器がん検診学会 , 日本超音波医学会 , 日本肝臓学会 , 日本消化器内視鏡学会 , 日本消化器病学会 , 日本内科学会 , American Society of Gene & Cell Therapy , American Association for the Study of Liver Diseases , International Society for Stem Cell Research

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