Mano Asuka

Research theme for competitive and other funds (7)：

2016 - 2019 The effects of the augmented non-neuronal cardiac cholinergic system on the central nervous system
2013 - 2016 A role of hypothalamic CRF on the progression of anorexia nervosa
2010 - 2012 The investigation of pathophysiological role of ghtelin and CRF on anorexia nervosa and discovery of a new therapeutic medication.
2008 - 2010 Study on energy storage mechanism of ghrelin using transgenic rats whose ghrelin receptor is suppressed
2005 - 2007 Study on the role of ghrelin in the regulatory mechanism of adiposity using transgenic rats whose ghrelin receptor expression is attenuated

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Papers (34)：

Takuma Maruyama, Asuka Mano, Toshiyuki Ishii, Yoshihiko Kakinuma, Makoto Kaneda. P2X 2 receptors supply extracellular choline as a substrate for acetylcholine synthesis. FEBS Open Bio. 2022. 12. 1. 250-257
Shino Oikawa, Yuko Kai, Asuka Mano, Hisayuki Ohata, Atsushi Kurabayashi, Masayuki Tsuda, Yoshihiko Kakinuma. Non-neuronal cardiac acetylcholine system playing indispensable roles in cardiac homeostasis confers resiliency to the heart. The journal of physiological sciences : JPS. 2021. 71. 1. 2-2
Shino Oikawa, Yuko Kai, Asuka Mano, Shigeo Nakamura, Yoshihiko Kakinuma. S-Nitroso-N-Pivaloyl-D-Penicillamine, a novel non-neuronal ACh system activator, modulates cardiac diastolic function to increase cardiac performance under pathophysiological conditions. International immunopharmacology. 2020. 84. 106459-106459
Shino Oikawa, Yuko Kai, Asuka Mano, Shuei Sugama, Naoko Mizoguchi, Masayuki Tsuda, Kazuyo Muramoto, Yoshihiko Kakinuma. Potentiating a non-neuronal cardiac cholinergic system reinforces the functional integrity of the blood brain barrier associated with systemic anti-inflammatory responses. Brain, behavior, and immunity. 2019. 81. 122-137
Shino Oikawa, Yuko Kai, Asuka Mano, Shigeo Nakamura, Yoshihiko Kakinuma. A Novel Nitric Oxide Donor, S-Nitroso-NPivaloyl-D-Penicillamine, Activates a Non-Neuronal Cardiac Cholinergic System to Synthesize Acetylcholine and Augments Cardiac Function. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2019. 52. 4. 922-934

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MISC (47)：

山口祐司, 岡崎幹子, 久保田万葉, 山田裕士, 大庭健史, 周東佑樹, 仲村優子, 原田太郎, 稲垣恭子, 眞野あすか, et al. クッシング症候群を合併したパラガングリオーマの1例. 日本内分泌学会雑誌. 2017. 93. 4. 1462-1462
Shino Oikawa, Yuko Kai, Asuka Mano, Hisayuki Ohata, Takahiro Nemoto, Yoshihiko Kakinuma. Various Regulatory Modes for Circadian Rhythmicity and Sexual Dimorphism in the Non-Neuronal Cardiac Cholinergic System (pg 1, 2017). JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH. 2017. 10. 4. 435-435
眞野あすか, 根本崇宏, 柿沼由彦, 芝崎保. 下垂体におけるCRF1型受容体様免疫活性に関する免疫組織化学的解析. 日本内分泌学会雑誌. 2017. 93. 1. 351-351
山口祐司, 岡崎幹子, 久保田万葉, 山田裕士, 大庭健史, 周東佑樹, 仲村優子, 原田太郎, 稲垣恭子, 眞野あすか, et al. クッシング症候群を合併したパラガングリオーマの1例. 日本臨床内分泌病理学会学術総会プログラム・抄録集. 2017. 21st. 62
眞野あすか, 柿沼由彦, 芝崎保. 過活動性拒食症モデル動物におけるCRFの機能異常の解明. 日本内分泌学会雑誌. 2016. 92. 1. 232-232

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Lectures and oral presentations (2)：

A role of corticotropin-releasing factor type 1 receptor in the rat nodose ganglion
迷走神経節におけるCRF1型受容体の役割についての解析
(第95回日本内分泌学会学術総会)

Professional career (1)：

医学 (日本医科大学)

Work history (1)：

Nippon Medical School

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