Zacharie Taoufiq

Affiliation and department：
Job title： Staff Scientist (Continuing)

Research field (5)： Neuroscience - general , Applied biochemistry , Functional biochemistry , Molecular biology , Neuropathology

Research keywords (10)： Organoid Assembloid , Machine learning , Artificial intelligence , iPS cells , Dementia , Alzheimer's disease , Schizophrenia , Synapse , Deep Proteomics , Molecular Neuroscience

Papers (16)：

Tetsuya Hori, Kohgaku Eguchi, Han-Ying Wang, Tomohiro Miyasaka, Laurent Guillaud, Zacharie Taoufiq, Satyajit Mahapatra, Hiroshi Yamada, Kohji Takei, Tomoyuki Takahashi. Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer's disease synapse model. eLife. 2022. 11
Zacharie Taoufiq, Momchil Ninov, Alejandro Villar-Briones, Han-Ying Wang, Toshio Sasaki, Michael C. Roy, Francois Beauchain, Yasunori Mori, Tomofumi Yoshida, Shigeo Takamori, Reinhard Jahn and Tomoyuki Takahashi. Hidden Proteome of Synaptic Vesicles in the Mammalian Brain. Proceedings of the National Academy of Sciences. 2020
Kohgaku Eguchi, Zacharie Taoufiq, Oliver Thorn-Seshold, Dirk Trauner, Masato Hasegawa, Tomoyuki Takahashi. Wild-Type Monomeric α-Synuclein Can Impair Vesicle Endocytosis and Synaptic Fidelity via Tubulin Polymerization at the Calyx of Held. The Journal of Neuroscience. 2017. 37. 25. 6043-6052
Nadine N'Dilimabaka, Zacharie Taoufiq, Sergine Zougbede, Serge Bonnefoy, Audrey Lorthiois, Pierre Oliver Couraud, Angelita Rebollo, Georges Snounou, Dominique Mazier, Alicia Moreno Sabater. P-falciparum Isolate-Specific Distinct Patterns of Induced Apoptosis in Pulmonary and Brain Endothelial Cells. PLOS ONE. 2014. 9. 3. e90692
Zacharie Taoufiq, Kohgaku Eguchi, Tomoyuki Takahashi. Rho-Kinase Accelerates Synaptic Vesicle Endocytosis by Linking Cyclic GMP-Dependent Protein Kinase Activity to Phosphatidylinositol-4,5-Bisphosphate Synthesis. JOURNAL OF NEUROSCIENCE. 2013. 33. 29. 12099-12104

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Patents (6)：

Invention of new synthetic drug that enables treatment of Alzheimer's disease
Proteomics-based receptor-ligand matching for optimizing human iPS cell reprogramming
Stable isotope peptides for quantitative analysis of synaptic vesicle proteins by mass spectrometry.
Neuronal culture medium and method for producing in vivo-like and enhanced synaptogenesis neuronal model.
Pharmaceutical compositions for the treatment of protozoan parasitic diseases.

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Professional career (1)：

PhD (Sorbonne Universite, Paris)

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