Kosugi Takahiro

コスギタカヒロ | Kosugi Takahiro

Affiliation and department：
Job title：助教

Research field (6)： Biophysics , Structural biochemistry , Biochemistry , Molecular biochemistry , Basic physical chemistry , Cell biology

Research theme for competitive and other funds (12)：

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Papers (15)：

Takahiro Kosugi, Mikio Tanabe, Nobuyasu Koga. De novo design of ATPase based on the blueprint optimized for harboring the P-loop motif. 2024
Yoshiaki Kamada, Chiharu Umeda, Yukio Mukai, Hokuto Ohtsuka, Yoko Otsubo, Akira Yamashita, Takahiro Kosugi. Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes. Journal of Cell Science. 2024. 137. 4
Koya Sakuma, Naohiro Kobayashi, Toshihiko Sugiki, Toshio Nagashima, Toshimichi Fujiwara, Kano Suzuki, Naoya Kobayashi, Takeshi Murata, Takahiro Kosugi, Rie Tatsumi-Koga, et al. Design of complicated all-α protein structures. Nature Structural & Molecular Biology. 2024. 31. 2. 275-282
Takahiro Kosugi, Tatsuya Iida, Mikio Tanabe, Ryota Iino, Nobuyasu Koga. Design of allosteric sites into rotary motor V₁-ATPase by restoring lost function of pseudo-active sites. Nature Chemistry. 2023. 15. 11. 1591-1598
Akihiro Otomo, Takahiro Kosugi. Tackle “Molecular Engine” by early-career researchers. Biophysics and Physicobiology. 2022. 19. e190039

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MISC (8)：

小杉貴洋. David Baker研究室を振り返って. 化学同人『化学』2024年12月号. 2024. 79. 27-27
Takahiro Kosugi. Structural Analysis for Engineering Protein and Interpreting its Mechanism. PHOTON FACTORY NEWS. 2024. 42. 1
小杉貴洋. 失われた機能を復活させてアロステリック部位を設計する方法:回転型分子モーターV₁-ATPaseで実証. 蛋白質科学会アーカイブ. 2023. 16. eEssay 13
小杉貴洋. タンパク質設計技術で分子モーターを加速する. 現代化学 = Chemistry today. 2023. 632. 24-27
小杉貴洋. タンパク質設計技術で目指す未来-特集現代化学の最前線2023. 現代化学 = Chemistry today. 2023. 622. 34-36

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Lectures and oral presentations (45)：

タンパク質機能の合理的設計・制御とその応用
(酵素工学研究会第92回講演会 2024)
Understanding and controlling functions of protein complexes by computational protein design
(2024 Frontier Symposium in Computational Chemistry, Biophysics, and Biological Sciences 2024)
Protein Design: Computational Designs and their Experimental Validations
(The 97th Annual Meeting of the Japanese Biochemical Society, Symposium "Beyond the molecular movies" 2024)
ノーベル化学賞2024『タンパク質のデザインと構造予測』
(第14回 CSJ化学フェスタ2024 2024ノーベル賞解説講演 2024)
計算機を用いたタンパク質の設計・改造
(第458回CBI学会講演会「創薬の多様化に対応するタンパク質構造観察技術の進化」 2024)

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Education (3)：

Professional career (1)：

Work history (9)：

2024/10 - 現在 Japan Science and Technology Agency
2020/12 - 現在国立研究開発法人科学技術振興機構「細胞の動的高次構造体」さきがけ研究者(兼任)
2015/10 - 現在 The Graduate University for Advanced Studies
2015/06 - 現在 Institute for Molecular Science Research Center of Integrative Molecular Systems
2024/04 - 2025/03 Kyushu University Institute for Materials Chemistry and Engineering

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Awards (4)：

2024/07 - National Institutes of Natural Sciences 13th National Institutes of Natural Sciences Young Researcher Award Control of Protein Complexes for Life Science Research
2021/06 - Protein Science Society of Japan Young Scientist Excellence Award 2021
2014/09 - 分子科学討論会優秀講演賞
2013/11 - 構造活性相関シンポジウム優秀発表賞

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