2016 - 2019 Searching and improvement of compounds that prevent production of odorous and toxic substances by periodontal pathogens
2014 - 2017 Elucidation and control of effect of short chain fatty acids on periodontopathogens
2013 - 2016 Screening of novel inhibitors to hydrogen sulfide-producing enzymes -based on enzyme structures and reaction mechanisms- that can prevent oral malodor
2012 - 2015 Approaches for elucidation of structure-function relationships of modular chitinases using a novel modeling method
2013 - 2014 口臭の原因となるメチルメルカプタンを産生する酵素に対する阻害剤の探索
2011 - 2013 Establishment of m olecular and structural basis of hydrogen sulfide-producing mechanism in Fusobacterium
2009 - 2012 Elucidation of structure and function relationship in multiple-domain chitinases probed by a combination of X-ray crystallography, solution scattering, and molecular dynamics simulation
2010 - 2011 二次代謝産物の多様性を生み出す生合成酵素の構造解析
2009 - 2011 Elucidation of hydrogen sulfide-producing mechanism by oral bacteria and searching for novel prophylactic drugs that prevent oral malodor
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Papers (29)：
Yoshida Y, Sato M, Nonaka T, Hasegawa Y, Kezuka Y. Characterization of the phosphotransacetylase-acetate kinase pathway for ATP production in Porphyromonas gingivalis. Journal of oral microbiology. 2019. 11. 1. 1588086-1588086
Xiang H, Okamura H, Kezuka Y, Katoh E. Physical and thermodynamic characterization of the rice gibberellin receptor/gibberellin/DELLA protein complex. Scientific Reports. 2018. 8. 1. 17719-17719
Yuichiro Kezuka, Tetsuo Ishida, Yasuo Yoshida, Takamasa Nonaka. Structural insights into the catalytic mechanism of cysteine (hydroxyl) lyase from the hydrogen sulfide-producing oral pathogen, Fusobacterium nucleatum. Biochemical Journal. 2018. 475. 4. 733-748
Jamal N, Kezuka Y, Nonaka T, Ohashi K, Nata K. Recombinant human REG Iα aggregates Staphylococcus aureus -Exhibits a lectin-like function. Advances in Bioscience and Biotechnology. 2017. 8. 3. 79-90
2007 - 現在 Iwate Medical University School of Pharmacy
2002 - 2007 Nagaoka University of Technology Faculty of Engineering, Department of BioEngineering
2001 - 2002 日研化学株式会社 大宮工場 品質管理課
Committee career (1)：
2014/01 - 現在 日本生化学会 生化学誌企画協力委員
Association Membership(s) (4)：
IWATE MEDICAL ASSOCIATION
, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY
, JAPANESE ASSOCIATION FOR ORAL BIOLOGY
, PROTEIN SCIENCE SOCIETY OF JAPAN
