Rchr
J-GLOBAL ID：201801001536586436   Update date: Oct. 04, 2024

Ohguchi Hiroto

Ohguchi Hiroto
Affiliation and department：
Kumamoto University Priority Organization for Innovation and Excellence

About Kumamoto University Priority Organization for Innovation and Excellence


Research field  (2)： Hematology and oncology ,  Tumor biology
Research keywords  (3)： multiple myeloma ,  epigenetics ,  hematologic malignancy
Research theme for competitive and other funds  (1)：
  • 2023 - 2026 The mechanisms of myeloma-driving transcriptional program
Papers (38)：
  • Yuri Miyamura, Shunsuke Kamei, Misaki Matsuo, Masaya Yamazaki, Shingo Usuki, Keiichiro Yasunaga, Akiyoshi Uemura, Yorifumi Satou, Hiroto Ohguchi, Takashi Minami. FOXO1 stimulates tip cell-enriched gene expression in endothelial cells. iScience. 2024. 27. 3. 109161-109161
  • Hiroto Ohguchi, Yasuyo Ohguchi, Sho Kubota, Kan Etoh, Ai Hamashima, Shingo Usuki, Takako Yokomizo-Nakano, Jie Bai, Takeshi Masuda, Yawara Kawano, et al. Multiple myeloma-associated DIS3 gene is essential for hematopoiesis but loss of DIS3 is insufficient for myelomagenesis. Blood Neoplasia. 2024. 100005-100005
  • Yasuyo Ohguchi, Hiroto Ohguchi. DIS3: The Enigmatic Gene in Multiple Myeloma. International journal of molecular sciences. 2023. 24. 4
  • Takeshi Harada, Hiroto Ohguchi, Asuka Oda, Michiyasu Nakao, Jumpei Teramachi, Masahiro Hiasa, Ryohei Sumitani, Masahiro Oura, Kimiko Sogabe, Tomoko Maruhashi, et al. Novel antimyeloma therapeutic option with inhibition of the HDAC1-IRF4 axis and PIM kinase. Blood advances. 2022. 7. 6. 1019-1032
  • Takeshi Masuda, Yuma Inamori, Arisu Furukawa, Maki Yamahiro, Kazuki Momosaki, Chih-Hsiang Chang, Daiki Kobayashi, Hiroto Ohguchi, Yawara Kawano, Shingo Ito, et al. Water Droplet-in-Oil Digestion Method for Single-Cell Proteomics. Analytical chemistry. 2022. 94. 29. 10329-10336
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MISC (64)：
  • 宮村 優里, 藤掛 彩夏, 後藤 唯花, 松尾 美沙希, 臼杵 慎吾, 大口 裕人, 佐藤 賢文, 南 敬. FOXO1のゲノムワイドな転写解析に基づく内皮特異的な遺伝子発現制御. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 2T18e-06
  • 大口 裕人, 中尾 光善, 南 敬. IL-6-JAK-STAT3経路は骨髄腫を駆動する転写プログラムの頑強性に寄与する(IL-6-JAK-STAT3 pathway confers the robustness of myeloma-driving transcriptional program). 日本癌学会総会記事. 2022. 81回. P-3070
  • 大口 裕人. IL-6-JAK-STAT3経路は骨髄腫を駆動する転写プログラムを支持する(IL-6-JAK-STAT3 pathway supports myeloma-driving transcriptional program). International Journal of Myeloma. 2022. 12. 3. 135-135
  • 大口 裕人, 扇屋 大輔, ワン・チンジャン, グライダー・バークレイ, パーク・ポール, 倉田 啓史, デヤオ・リー, 増田 豪, 日野 信次朗, 臼杵 慎吾, et al. KDM5Aは多発性骨髄腫においてMYC標的遺伝子の維持に必須な因子である(KDM5A is a vulnerability of MYC target genes essential to multiple myeloma). International Journal of Myeloma. 2021. 11. 2. 84-84
  • 古川 亜里朱, 増田 豪, 大口 裕人, 金子 由依, 伊藤 慎悟, 大槻 純男. 多発性骨髄腫におけるCRBN遺伝子変異非依存的レナリドミド耐性機構の解明. 日本薬学会年会要旨集. 2020. 140年会. 27P-am186S
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Education (2)：
  • 2003 - 2007 東北大学大学院 医学系研究科
  • 1994 - 2000 Tohoku University Faculty of Medicine School of Medicine
Professional career (1)：
  • PhD (Tohoku University)
Work history (8)：
  • 2018/04 - 現在 Kumamoto University Associate professor
  • 2016/07 - 2018/03 Dana-Farber Cancer Institute Department of Medical Oncology Instructor
  • 2011/04 - 2016/06 Dana-Farber Cancer Institute Department of Medical Oncology Research fellow
  • 2009/05 - 2011/03 Tohoku University Hospital Department of Hematology and Rheumatology Assistant professor
  • 2009/04 - 2009/04 Tohoku University Hospital Department of Hematology and Rheumatology
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Awards (5)：
  • 2019/11 - 日本白血病研究基金研究助成事業・一般研究賞
  • 2019/05 - 日本骨髄腫学会奨励賞 日本骨髄腫学会奨励賞
  • 2017 - Dana Farber/Harvard Cancer Center SPORE in Multiple Myeloma Career Enhancement Award
  • 2015/12 - American Society of Hematology Abstract Achievement Awards
  • 2010 - The Uehara Memorial Foundation Research fellowship
Association Membership(s) (1)：
日本癌学会
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