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J-GLOBAL ID:201801001574232710   Update date: Jan. 31, 2024

Osuga Takahiro

Osuga Takahiro
Affiliation and department:
Research field  (1): Tumor diagnostics and therapeutics
Research theme for competitive and other funds  (6):
  • 2021 - 2024 Novel strategies for the treatment of solid tumors with CAR and CIML NK cells
  • 2020 - 2023 膵臓癌に対する抗がん剤の腫瘍指向性を持つ新規DDSの開発
  • 2019 - 2022 Developing a novel therapeutic strategy for advanced gastric cancer using the new genetic pathway of HIF-1 alpha.
  • 2017 - 2020 Development of a new treatment for colorectal cancer using the glucose metabolism characteristics.
  • 2015 - 2016 FUTを標的とした進行大腸癌に対する抗EMT療法の開発
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Papers (28):
  • Ryo Ito, Koji Miyanishi, Tomohiro Kubo, Kota Hamaguchi, Takahiro Osuga, Shingo Tanaka, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Minoru Nagayama, et al. Synergistic antitumor effect of histone deacetylase class IIa inhibitor with lenvatinib in hepatocellular carcinoma. Hepatology international. 2023. 17. 3. 735-744
  • Kota Hamaguchi, Koji Miyanishi, Takahiro Osuga, Shingo Tanaka, Ryo Ito, Hiroki Sakamoto, Tomohiro Kubo, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, et al. Association between Hepatic Oxidative Stress Related Factors and Activation of Wnt/β-Catenin Signaling in NAFLD-Induced Hepatocellular Carcinoma. Cancers. 2022. 14. 9
  • Takahiro Osuga, Koji Miyanishi, Kota Hamaguchi, Shingo Tanaka, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Junji Kato. A case of acute exacerbation of chronic hepatitis C during the course of adrenal Cushing's syndrome. Clinical Case Reports. 2022. 10. 2
  • Takahiro Osuga, Koji Miyanishi, Ryo Ito, Shingo Tanaka, Kota Hamaguchi, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Minoru Nagayama, Yasutoshi Kimura, et al. A Case of Unresectable Combined Hepatocellular-Cholangiocarcinoma Successfully Treated with Lenvatinib. Case reports in oncology. 2022. 15. 1. 318-325
  • Yusuke Sugama, Koji Miyanishi, Takahiro Osuga, Shingo Tanaka, Kota Hamaguchi, Ryo Ito, Hiroki Sakamoto, Tomohiro Kubo, Hiroyuki Ohnuma, Kazuyuki Murase, et al. Combination of psoas muscle mass index and neutrophil/lymphocyte ratio as a prognostic predictor for patients undergoing nonsurgical hepatocellular carcinoma therapy. JGH Open. 2021. 5. 12. 1335-1343
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MISC (9):
  • Hiroyuki Ohnuma, Yasushi Sato, Naotaka Hayasaka, Teppei Matsuno, Chisa Fujita, Masanori Sato, Takahiro Osuga, Masahiro Hirakawa, Koji Miyanishi, Tamotsu Sagawa, et al. Neoadjuvant chemotherapy with docetaxel, nedaplatin, and fluorouracil for resectable esophageal cancer: A phase II study. Cancer science. 2018. 109. 11. 3554-3563
  • 大沼 啓之, 佐藤 康史, 大須賀 崇裕, 林 毅, 佐藤 勉, 宮西 浩嗣, 小船 雅義, 瀧本 理修, 加藤 淳二, 佐川 保, et al. 進行食道癌に対するdocetaxel、nedaplatin、5-FU、放射線同時併用療法(DNF-R)の第I/II相試験. 北海道医学雑誌. 2015. 90. 2. 152-153
  • Y. Sato, H. Ohnuma, M. Hirakawa, T. Osuga, Y. Okagawa, T. Sagawa, Y. Takahashi, M. Takahashi, M. Maeda, S. Katsuki, et al. Docetaxel, cisplatin and S-1 (DCS) combination chemotherapy for gastric cancer patients with peritoneal metastasis: a multi-institute retrospective study. EUROPEAN JOURNAL OF CANCER. 2015. 51. S431-S431
  • Junji Kato, Rishu Takimoto, Takahiro Osuga, Michihiro Ono, Yutaka Okagawa, Naoki Uemura, Yohei Arihara, Yasushi Sato, Fumito Tamura. Accumulation of L-Fucose Is a Functional Target for Colorectal Cancer Therapy. GASTROENTEROLOGY. 2015. 148. 4. S948-S948
  • Yasushi Sato, Hiroyuki Ohnuma, Masahiro Hirakawa, Yutaka Okagawa, Takahiro Osuga, Kazuyuki Murase, Kohichi Takada, Yutaka Kawano, Satoshi Iyama, Tsuyoshi Hayashi, et al. A phase I/II study of definitive chemoradiotherapy with docetaxel, nedaplatin, and 5-fluorouracil (DNF-R) for advanced esophageal cancer. JOURNAL OF CLINICAL ONCOLOGY. 2015. 33. 3
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Education (2):
  • 2011 - 2015 Sapporo Medical University Graduate School of Medicine
  • 2003 - 2009 Sapporo Medical University School of Medicine
Work history (6):
  • 2018/04 - 現在 Sapporo Medical University
  • 2016/04 - 2018/03 Massachusetts General Hospital GI Unit Postdoctoral Research Fellow
  • 2015/04 - 2016/03 Sapporo Medical University
  • 2011/04 - 2015/03 Sapporo Medical University Graduate School of Medicine
  • 2009/04 - 2011/03 Sapporo Medical University Hospital
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