Hara Hideaki

2017 - 2020 Development of therapeutic drugs targeting VGF-modifying peptides in retinal diseases

2016 - 2019 The role of progranulin in retinal regeneration

2014 - 2018 Structural and morphorogical changes after glaucoma surgery

2015 - 2017 Nrf2 activator attenuates brain ischemia-reperfusion injury.

2014 - 2017 A study for protective mechanisms of VGF, a neurosecretory peptide, in glaucomatous optic nerve degeneration

2013 - 2016 Studies on topical application of BONAC nucleic with liposomal formulation for advanced clinical treatment

2013 - 2016 Identification of glycoprotein nonmetastatic melanoma protein B (GPNMB) receptor and effect of GPNMB in higher brain function

2013 - 2016 Involvement of aquaporin in the formation of optic nerve edema and protective effects of blocking the AQP channels.

2011 - 2013 A study for protective mechanisms of VGF, a neurosecretory peptide, in retinal injury

2010 - 2012 緑内障性神経障害:網膜から高次脳神経及びグリア細胞に及ぶ系統的器質障害機構の解明

2010 - 2012 Involvement of activated P2X7 receptor in disorder of retinal ganglion cells in animal models of glaucoma

2010 - 2012 Determination of neuro-protective effects of statin on the retinal injuries through activated glial cells.

2009 - 2011 Novel Dosage form design for ocular and pulmonary drug delivery based on analysis of behavior of nano-particle as drug carrier

2009 - 2011 Molecular design and chemical genetic approach of bio-probe for anti-angiogenic therapy

2009 - 2011 Morphological and functional changes in visual cortex after retinal damage and its pharmacological approach

2008 - 2010 A study of molecular mechanisms of endoplasmic reticulum stress in retinal ganglion cell death

2007 - 2009 Research on the roles of metallothioneins in aging, brain ischemia and metabolic syndrome and drug discover

2007 - 2008 Changes in visual fields and retinal function in high intraocular pressure model of monkeys

2007 - 2008 SIRT1による神経細胞保護の分子機構の解明

2006 - 2008 Damage of retinal ganglion cells : Mechanism of the cell death in the local and central nervous system and protection and regeneration of the neural cells.

2006 - 2007 緑内障及び糖尻病網膜症の病態におけるアルツハイマー病の関連性について

2005 - 2006 Functional changes mediated by high-intraocular pressure-induced optic nerve damage in lateral geniculate body and visual cortex of monkeys.