Hara Satoshi

ハラサトシ | Hara Satoshi

Affiliation and department：

Research field (1)： Zoological sciences

Research keywords (3)：ゲノム編集 , エピジェネティクス , ゲノムインプリンティング

Research theme for competitive and other funds (5)：

2023 - 2026 Investigation of molecular mechanisms for overgrowth and aberrant hypermethylation using H19-ICR mutant mouse panel
2022 - 2025 Exploring a novel function of nuclear transport molecules in male and female gametogenesis and elucidation of the infertility mechanism
2019 - 2022 IG-DMR母方欠失マウスにおいて周産期致死を引き起こす責任配列の探索
2017 - 2019 ヒト配列ノックインマウスを用いたIG-DMRによるインプリント制御機構の解析
2015 - 2017 ゲノム編集効率に寄与するマウス受精卵のDNA修復機構の解明

Papers (24)：

Satoshi Hara, Fumikazu Matsuhisa, Shuji Kitajima, Hitomi Yatsuki, Musashi Kubiura-Ichimaru, Ken Higashimoto, Hidenobu Soejima. Identification of responsible sequences which mutations cause maternal H19-ICR hypermethylation with Beckwith-Wiedemann syndrome-like overgrowth. Communications Biology. 2024. 7. 1
Ken Higashimoto, Feifei Sun, Eri Imagawa, Ken Saida, Noriko Miyake, Satoshi Hara, Hitomi Yatsuki, Musashi Kubiura-Ichimaru, Atsushi Fujita, Takeshi Mizuguchi, et al. Whole-exome sequencing reveals causative genetic variants for several overgrowth syndromes in molecularly negative Beckwith-Wiedemann spectrum. Journal of medical genetics. 2024
Ken Higashimoto, Satoshi Hara, Hidenobu Soejima. DNA Methylation Analysis Using Bisulfite Pyrosequencing. Methods in Molecular Biology. 2023
Saori Aoki, Ken Higashimoto, Hidenori Hidaka, Yasufumi Ohtsuka, Shigehisa Aoki, Hiroyuki Mishima, Koh-ichiro Yoshiura, Kazuhiko Nakabayashi, Kenichiro Hata, Hitomi Yatsuki, et al. Aberrant hypomethylation at imprinted differentially methylated regions is involved in biparental placental mesenchymal dysplasia. Clinical Epigenetics. 2022. 14. 1
Hidenobu Soejima, Satoshi Hara, Takashi Ohba, Ken Higashimoto. Placental Mesenchymal Dysplasia and Beckwith-Wiedemann Syndrome. Cancers. 2022. 14. 22. 5563-5563

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MISC (6)：

小川湧也, 小川湧也, 原聡史, 浜田万里果, 岡村晴紀, 岡村晴紀, 土屋育, 土屋育, 辻敦美, 後藤友二, et al. SNPsを利用したゲノム編集による疾患候補領域重複マウスの作製. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
小林広香, 佐藤麗, 豊田雅士, 梅澤明弘, 山下聡, 原聡史, 高田修治, 黒田雅彦. ゲノム編集技術を用いた、難治性疾患の分子機構解明に向けた検討. 東京医科大学雑誌 = The Journal of Tokyo Medical University. 2016. 74. 2. 205-206
加藤朋子, 原聡史, 玉野萌恵, 小川湧也, 岡安春佳, 乾雅史, 浅原弘嗣, 高田修治. マウス軟骨・生殖腺特異的Sox9エンハンサーの同定と機能解析. 日本生化学会大会(Web). 2015. 88th
原聡史, 川原玲香, 尾畑やよい, 河野友宏. マウス卵母細胞におけるゲノム刷込みの分子機構. The Journal of Reproduction and Development. 2013. 106. 0. AW-6-AW-6
YAMAKAMI Reina, OGATA Mio, HARA Satoshi, OBATA Yayoi, KONO Tomohiro. Ectopic expression of DNMT3A and DNMT3L results in lethality by 16 weeks of age in mice. 2013. 30. 2. S103

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Education (2)：

2009 - 2014 Tokyo University of Agriculture Graduate School of Agriculture Department of Bio-Science
2005 - 2009 Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Bio-Science

Professional career (1)：

Work history (2)：

Awards (3)：

Association Membership(s) (3)：

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , 日本エピジェネティクス研究会 , SOCIETY FOR REPRODUCTION AND DEVELOPMENT

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