Rchr
J-GLOBAL ID：201801001890209666   Update date: Feb. 14, 2024

Osaka Mizuko

オオサカ ミズコ | Osaka Mizuko
Affiliation and department：
Tokyo Medical and Dental University Institute of Research Research Facility Cluster Life Science and Bioethics Research Center

About Tokyo Medical and Dental University Institute of Research Research Facility Cluster Life Science and Bioethics Research Center


Job title： Assistant Professor
Research field  (1)： Medical biochemistry
Research keywords  (1)： 動脈硬化症 血管生物学
Research theme for competitive and other funds  (6)：
  • 2010 - 現在 in vivoでの血管内皮と白血球相互作用の可視化
  • 2016 - 2017 動脈硬化症初期段階における血管内膜内在性樹状細胞の役割
  • 2015 - 2017 動脈硬化症の発症・進展過程における白血球浸潤の可視化
  • 2012 - 2014 心腎連関の原因物質としての尿毒症毒素の血管傷害メカニズム
  • 動脈硬化巣形成過程における好中球細胞外トラップ(NET)と単球接着の可視化
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Papers (147)：
  • Osaka M, Deushi M, Aoyama J, Funakoshi T, Ishigami A, Yoshida M. High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3. JACC. Basic to translational science. 2021. 6. 6. 507-523
  • Dewan SMR, Osaka M, Deushi M, Yoshida M. Complement C5a-triggered differentiated HL-60 stimulates migration of THP-1 monocytic leukocytes via secretion of CCL2. FEBS open bio. 2021. 11. 5. 1374-1381
  • Tsuru Hiromi, Osaka Mizuko, Yoshida Masayuki. Complement Factor D Facilitates the Development of Fatty Liver under Long-term but not Short-term High-fat Diet-feeding Conditions(和訳中). 日本循環器学会学術集会抄録集. 2021. 85回. OE113-3
  • Dewan Syed, Masudur Rahman, Osaka Mizuko, Deushi Michiyo, Yoshida Masayuki. C5a-stimulated Neutrophil-like Differentiated HL-60 Induced Migration of Monocytic THP-1 through the Secretion of MCP-1(和訳中). 日本循環器学会学術集会抄録集. 2021. 85回. OE029-5
  • Inoue Reiko, Nishi Hiroshi, Osaka Mizuko, Yoshida Masayuki, Nangaku Masaomi. NEUTROPHIL INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (EIF2AK2) PROMOTES ADHESION IN NON-VIRAL INFLAMMATORY KIDNEY DISEASE. NEPHROLOGY. 2020. 25. 35-35
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MISC (2)：
Lectures and oral presentations  (43)：
  • 動脈硬化症関連血管炎症反応における好中球でのヒストンシトルリン化の重要性
    (第43回日本分子生物学会年会 2020)
  • Critical Role of Complement Factor D in the Development of High-fat Diet-induced Fatty Liver
    (第84回日本循環器学会学術集会 2020)
  • C5a elevates MCP-1 expression in neutrophil-like differentiated HL60 via NF-κB signaling pathway
    (第84回日本循環器学会学術集会 2020)
  • アテローム性動脈硬化症発症前血管炎症におけるヒストンシトルリン化好中球の重要性
    (第52回日本動脈硬化学会総会・学術集会 2020)
  • 選択的PPARaアゴニスト、ペマフィブラートはLDL受容体欠損マウス大腿動脈における高中性脂肪血症を改善し、白血球接着を抑制する
    (第52回日本動脈硬化学会総会・学術集会 2020)
ｍore...
Education (1)：
  • 1989 - 1994 Tokyo University of Science Faculty of Engineering Science biological science and technology
Professional career (1)：
  • PhD (Tokyo Medical and Dental University)
Work history (7)：
  • 2020/10/01 - 現在 Tokyo Medical and Dental University Institute of Research Research Facility Cluster Life Science and Bioethics Research Center Assistant Professor
  • 2014/10/01 - 現在 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Endowed Departments Department of Nutrition and Metabolism in Cardiovascular Disease Project Assistant Professor
  • 2011/04/01 - 現在 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Public Health Life Sciences and Bioethics Assistant Professor
  • 2017/05/01 - 2020/09/30 Tokyo Medical and Dental University Institute of Research Research Facility Cluster Life Science and Bioethics Research Center Assistant Professor
  • 2017/04/01 - 2017/04/30 Tokyo Medical and Dental University Institute of Research Research Facility Cluster Life Science and Bioethics Research Center Assistant Professor
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Committee career (3)：
  • 2019/07 - 現在 日本動脈硬化学会 評議員
  • 2018/04 - 現在 日本血管生物医学会 事務
  • 2014/04 - 現在 日本血管生物医学会 日本血管生物医学会評議委員
Association Membership(s) (5)：
日本生化学会 ,  日本動脈硬化学会 ,  日本分子生物医学会 ,  血管生物医学会 ,  日本循環器学会
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