Akahane Koshi

アカハネコウシ | Akahane Koshi

Affiliation and department：
Job title： Senior Assistant Professor

Research field (5)： Tumor diagnostics and therapeutics , Tumor biology , Genomics , Hematology and oncology , Fetal medicine/Pediatrics

Research keywords (2)： Drug sensitivity , Acute lymphoblastic leukemia

Research theme for competitive and other funds (13)：

2022 - 2025 難治性急性リンパ性白血病に対するプレシジョン・メディシンを目指した多分野融合研究
2019 - 2022 Integrated study aiming at development of precision medicine for poor prognostic acute lymphoblastic leukemia
2019 - TP53変異が急性リンパ性白血病の抗がん剤耐性に与える影響の解析
2016 - 2019 T細胞型急性リンパ性白血病におけるTYK2を対象とした新規治療法の開発
2013 - 2015 Significance of innate resistance to mitochondrial apoptosis in high-risk T-ALL

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Papers (116)：

Atsushi Watanabe, Lu Wang, Tze King Tan, Kevin Y Urayama, Toshihiko Kizuki, Chiaki Komatsu, Keiko Kagami, Tamao Shinohara, Shin Kasai, Minori Tamai, et al. Acquired copy number amplification at the MYC enhancer in human B-precursor acute lymphoblastic leukemia cell lines. Cancer science. 2024
Kazuya Takahashi, Thao Thu Thi Nguyen, Atsushi Watanabe, Hiroki Sato, Kinuko Saito, Minori Tamai, Daisuke Harama, Shin Kasai, Koshi Akahane, Kumiko Goi, et al. Involvement of BCR::ABL1 in laminin adhesion of Philadelphia chromosome-positive acute lymphoblastic leukemia through upregulation of integrin α6. Cancer reports (Hoboken, N.J.). 2024. 7. 4. e2034
Shin Kasai, Minori Tamai, Eiji Sugihara, Naoki Oishi, Kyoko Hinata, Koshi Akahane, Kumiko Goi, Yuko Hata, Tetsuo Kondo, Takahiko Mitsui, et al. In utero tumor development and identification of CTNNB1 mutation in a newborn case of ossifying renal tumor of infancy. Pediatric Blood & Cancer. 2024
Thao Nguyen, Tomomi Aida, Yuka Iijima-Yamashita, Minori Tamai, Akiko Nagamachi, Keiko Kagami, Chiaki Komatsu, Shin Kasai, Koshi Akahane, Kumiko Goi, et al. Application of prime editing system to introduce TP53 R248Q hotspot mutation in acute lymphoblastic leukemia cell line. Cancer Science. 2024
Atsushi Watanabe, Kunio Miyake, Yuriko Yamada, Ei-Ichiro Sunamura, Takuya Yotani, Keiko Kagami, Shin Kasai, Minori Tamai, Daisuke Harama, Koshi Akahane, et al. Utility of ASNS gene methylation evaluated with the HPLC method as a pharmacogenomic biomarker to predict asparaginase sensitivity in BCP-ALL. Epigenetics. 2023. 18. 1. 2268814-2268814

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MISC (83)：

Minori Tamai, Thao Nguyen, Chiaki Komatsu, Keiko Kagami, Shin Kasai, Daisuke Harama, Koshi Akahane, Kumiko Goi, Takeshi Inukai. p210 and p190 BCR::ABL1 INDUCE DIFFERENT GENE EXPRESSION PROFILES IN THE ARTIFICIAL PHILADELPHIA CHROMOSOME-POSITIVE LEUKEMIAS CREATED BY CRISPR/Cas9 SYSTEM. PEDIATRIC BLOOD & CANCER. 2022. 69
原間大輔, 赤羽弘資, 渡邊敦, 篠原珠緒, 大城浩子, 合井久美子, 沼野史典, 蓮田憲夫, 犬飼岳史. Progressive dyspnea due to airway constriction by primary tumor in an infant with posterior mediastinum neuroblastoma. 日本小児血液・がん学会雑誌(Web). 2021. 58. 4
渡邊敦, 原間大輔, 笠井慎, 赤羽弘資, 合井久美子, 犬飼岳史. Development of kidney stones during induction therapy in a girl with T-cell acute lymphoblastic leukemia. 日本小児血液・がん学会雑誌(Web). 2021. 58. 4
玉井望雅, 玉井望雅, 笠井慎, グエンタオ, 加賀美恵子, 渡邊敦, 赤羽弘資, 矢ヶ崎英晃, 合井久美子, 三宅邦夫, et al. Associations of NR3C1 mutations and glucocorticoid resistance in BCP-ALL cell lines. 日本血液学会学術集会抄録(Web). 2021. 83rd
杣津晋平, 杣津晋平, 田中庸一, THAO Nguyen, 加賀美恵子, 笠井慎, 玉井望雅, 村上寧, 渡邊敦, 赤羽弘資, et al. 白血病細胞のmercaptopurine長期暴露による感受性テストの有用性. 日本血液学会学術集会抄録(Web). 2020. 82nd

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Books (4)：

【特集造血器腫瘍における治療抵抗性の分子機構】急性リンパ性白血病の薬剤耐性機序
科学評論社 2018
【特集血液疾患、診断と治療のtrends & topics】急性リンパ性白血病
MEDICAL VIEW 2017
【小児固形がんの最新のトピックス】細胞生物学領域の進歩
東京医学社 2016
TLX1の過剰発現によるT-ALLの発症機序 -白血化機序の解明におけるトランスジェニックマウスの応用の新たな可能性-
科学評論社 2011

Lectures and oral presentations (35)：

Development of relapsed or refractory acute lymphoblastic leukemia models using genome-editing technology
(第63回日本小児血液・がん学会 2021)
An infant case of FGFR1 tyrosine kinase domain duplication-positive tumor that developed on the left leg
(第63回日本小児血液・がん学会 2021)
Oral beclomethasone dipropionate for treatment of gastrointestinal GVHD in pediatric HSCT patients
(第43回日本造血細胞移植学会 2021)
A neonatal giant hepatic hemangioma case accompanied by Kasabach-Merritt syndrome and cardiac failure
(第62回日本小児血液・がん学会 2020)
Disruption of TP53 by CRISPR/Cas9 system induces multiagent resistance in BCP-ALL cell lines
(第82回日本血液学会 2020)

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Education (2)：

2002 - 2006 University of Yamanashi School of Medicine 医学系研究科生化学専攻
1994 - 2000 University of Yamanashi School of Medicine 医学部医学科

Professional career (2)：

PhD (University of Yamanashi, Graduate School of Medicine)
MD

Work history (7)：

2023/07 - University of Yamanashi, School of Medicine, Department of Pediatrics
2016/01 - 2023/06 Department of Pediatrics, School of Medicine, University of Yamanashi Assistant professor
2012/07/01 - 2015/12/31 Dana-Farber Cancer Institute Department of Pediatric Oncology Research Fellow
2009/04/01 - 2012/06/30 Department of Pediatrics, Faculty of Medicine, University of Yamanashi Assistant professor
2006/04/01 - 2009/03/31 Department of Pediatrics, Faculty of Medicine, University of Yamanashi 研修登録医

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Committee career (1)：

2021/07 - 日本小児血液・がん学会評議員

Awards (1)：

2022/09 - 山梨大学山梨大学優秀教員奨励制度研究特別奨励賞

Association Membership(s) (4)：

Japan Pediatric Society , Japanese Society of Hematology , The Japanese Society of Pediatric Hematology / Oncology , Japanese Society for Transplantation and Cellular Therapy

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