Rchr
J-GLOBAL ID：201801002009703498
Update date: Nov. 19, 2024
Yoshiyuki Manabe
マナベ ヨシユキ | Yoshiyuki Manabe
Affiliation and department：
Job title：
Associate Professor
Research field (1)：
Bioorganic chemistry
Research keywords (3)：
ケミカルバイオロジー
, グリコシル化
, 糖鎖
Research theme for competitive and other funds (18)：
- 2020 - 2025 Elucidation of glycan function by synthetic glycans and glycan remodeling systems and their application to new immunotherapies
- 2021 - 2024 糖鎖・糖鎖修飾膜タンパク質を「つくる」ことによるタンパク質膜動態の可視化
- 2021 - 2024 Regulation of membrane dynamics by glycan chemical knock-in
- 2020 - 2023 シアリル糖鎖による免疫調節の分子基盤解明を目指したボトムアップアプローチ
- 2020 - 2022 Analysis and control of glycan function on cell surface crowding biosytems by synthetic biology
- 2020 - 2021 Functional analysis of glycans and immunoregulation by using synthetic glycans and glycan remodeling
- 2019 - 2021 細菌由来複合糖質ならびに動物由来糖鎖の合成と構造・生物機能研究
- 2018 - 2021 Understanding how fundamental biomolecules are synthesized in primordial microbes
- 2017 - 2020 Establishment of a humoral immunity evaluation system based on the pregnant immunity system
- 2016 - 2020 Analysis of cell surface glycan networks to elucidate the function of glycan posttranslatinal modification on membrane proteins
- 2016 - 2020 Elucidation and control of immune function regulated by cell surface glycans
- 2015 - 2020 Creation of Glycoconjugated Meddle Molecules for Realizing Glyco-medicine
- 2017 - 2019 Development of new antiprotozoal therapy using molecules that recruit immune cells
- 2015 - 2019 Development of a novel therapy and assessment method for NASH targeting glycosylation modification
- 2014 - 2016 Development of novel cancer immunotherapy utilizing hyperacute rejection induced by alpha-gal epitope
- 2013 - 2016 Synthesis and regulation of the phosphorylated signal in vivo template assisted synthesis
- 2011 - 2015 Studies on biological function of glycoconjugates using synthetic probes and in vivo imaging
- 2008 - 2010 光親和性エピトープタグプローブを利用した就眠運動関連受容体の同定と生物有機化学
Show all
Papers (103)：
-
Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Kentaro Hisada, Sifan Feng, Yuichiro Kadonaga, Kazuhiro Ooe, Tadashi Watabe, Yoshiyuki Manabe, Atsushi Shimoyama, Masashi Murakami, et al. Development of LAT1-Selective Nuclear Medicine Therapeutics Using Astatine-211. International Journal of Molecular Sciences. 2024. 25. 22. 12386-12386
-
Yoshiyuki Manabe, Tomoyuki Takebe, Satomi Kasahara, Koki Hizume, Kazuya Kabayama, Yoshihiro Kamada, Akiko Asakura, Shinichiro Shinzaki, Shinji Takamatsu, Eiji Miyoshi, et al. Development of a FUT8 Inhibitor with Cellular Inhibitory Properties. Angewandte Chemie International Edition. 2024
-
Al Arofatus Naini, Tri Mayanti, Erina Hilmayanti, Xuhao Huang, Kazuya Kabayama, Atsushi Shimoyama, Yoshiyuki Manabe, Koichi Fukase, Unang Supratman. Immunomodulatory of sesquiterpenoids and sesquiterpenoid dimers-based toll-like receptor 4 (TLR4) from Dysoxylum parasiticum stem bark. Scientific Reports. 2024. 14. 1
-
Ayane Miura, Yoshiyuki Manabe, Kenichi G. N. Suzuki, Hiroki Shomura, Soichiro Okamura, Asuka Shirakawa, Kumpei Yano, Shuto Miyake, Koki Mayusumi, Chun-Cheng Lin, et al. De Novo Glycan Display on Cell Surfaces Using HaloTag: Visualizing the Effect of the Galectin Lattice on the Lateral Diffusion and Extracellular Vesicle Loading of Glycosylated Membrane Proteins. Journal of the American Chemical Society. 2024
-
Yoshiyuki Manabe, Koki Hizume, Yohei Takakura, Shinji Takamatsu, Eiji Miyoshi, Yoshihiro Kamada, Ramón Hurtado-Guerrero, Koichi Fukase. Systematic Strategy for the Development of Glycosyltransferase Inhibitors: Diversity-Oriented Synthesis of FUT8 Inhibitors. Synlett. 2024. 35. 11. 1273-1278
ｍore...
MISC (54)：
-
晦日光希, 真鍋良幸, 真鍋良幸, 高倉陽平, 樺山一哉, 樺山一哉, 深瀬浩一, 深瀬浩一. Development of Golgi-selective drug delivery system and its application for glycan structure modulation. 日本化学会春季年会講演予稿集(Web). 2024. 104th
-
晦日光希, 真鍋良幸, 真鍋良幸, 高倉陽平, 樺山一哉, 樺山一哉, 深瀬浩一, 深瀬浩一. Investigation of Golgi selective drug delivery and its application for glycan structure regulation. 日本糖質学会年会要旨集. 2023. 42nd
-
飯塚結貴, 松本拓也, 真鍋良幸, 真鍋良幸, 真鍋良幸, 樺山一哉, 樺山一哉, 樺山一哉, 深瀬浩一, 深瀬浩一, et al. Glycan display on the cell surface by proximity labeling and its application for biofunctional regulation. 日本糖質学会年会要旨集. 2023. 42nd
-
兼田加珠子, 兼田加珠子, 王谷英達, 王谷英達, 王谷英達, 渡部直史, 渡部直史, 渡部直史, 真鍋良幸, 真鍋良幸, et al. Development of short-lived alpha-emitting nuclear medicine aiming at rare cancer treatment. 日本癌学会学術総会抄録集(Web). 2023. 82nd
-
HIRAO Kohtaro, MANABE Yoshiyuki, FUKASE Koichi. Posttranslational glycan modification in Thermococcus kodakarensis: discovery and synthesis of myo-inositol containing N-glycan. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
ｍore...
Books (2)：
-
セルフアジュバンティングストラテジーによる合成ワクチン開発
技術情報協会 2017 ISBN:9784861046872
-
Glycochemical Synthesis: Strategies and Applications, Chapter8, Sugar Synthesis by microfluidic Techniques
Wiley 2016 ISBN:9781118299845
Education (3)：
- 2008 - 2011 東北大学大学院理学研究科化学専攻 博士課程
- 2006 - 2008 東北大学大学院理学研究科化学専攻 修士課程
- 2002 - 2006 東北大学理学部化学科
Professional career (1)：
Work history (4)：
- 2024/06 - 現在 Osaka University Graduate School of Science Associate professor
- 2012/04 - 現在 大阪大学大学院理学研究科化学専攻 助教
- 2011/04 - 2012/03 九州大学大学院理学研究院化学部門 学術研究員
- 2008/03 - 2011/03 東北大学大学院理学研究科 日本学術振興会特別研究員DC1
Awards (2)：
- 2021/12 - 有機合成化学奨励賞
- 2020/05 - 日本糖質学会 奨励賞
Return to Previous Page
