Imataka Hiroaki

イマタカヒロアキ | Imataka Hiroaki

Affiliation and department：
Homepage URL (1)： http://www.eng.u-hyogo.ac.jp/group/group37/

Research field (1)： Systems genomics

Research keywords (5)： artificial cells , reconstitution , translation , protein synthesis , synthetic biology

Research theme for competitive and other funds (19)：

2021 - 2027 Comprehensive study of in vivo protein folding in proteostasis network
2022 - 2026 Development of the reconstituted folding/translation-coupled system to analyze relevant diseases
2021 - 2026 Analysis of non-domain type RNA sequences in the mRNA untranslated region
2022 - 2025 ポリアミンが誘導するリピート病の発症機構とその制御による病態抑制効果の解明
2020 - 2024 Molecular mechanism of RAN translation

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Papers (90)：

Kodai Machida, Rin Tanaka, Seraya Miki, Shotaro Noseda, Mayumi Yuasa-Sunagawa, Hiroaki Imataka. High-throughput screening for a SARS-CoV-2 frameshifting inhibitor using a cell-free protein synthesis system. BioTechniques. 2024. 76. 4. 161-168
Hayato Ito, Kodai Machida, Mayuka Hasumi, Morio Ueyama, Yoshitaka Nagai, Hiroaki Imataka, Hideki Taguchi. Reconstitution of C9orf72 GGGGCC repeat-associated non-AUG translation with purified human translation factors. Scientific reports. 2023. 13. 1. 22826-22826
Akihiro Kimura, Takeshi Takagi, Thiprampai Thamamongood, Satoshi Sakamoto, Takumi Ito, Iwao Seki, Masahiro Okamoto, Hiroyuki Aono, Satoshi Serada, Tetsuji Naka, et al. Extracellular aaRSs drive autoimmune and inflammatory responses in rheumatoid arthritis via the release of cytokines and PAD4. Annals of the rheumatic diseases. 2023. 82. 9. 1153-1161
Yosuke Ito, Yuhei Chadani, Tatsuya Niwa, Ayako Yamakawa, Kodai Machida, Hiroaki Imataka, Hideki Taguchi. Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes. Nature communications. 2022. 13. 1. 7451-7451
Kodai Machida, Shoma Miyawaki, Kuru Kanzawa, Taiki Hakushi, Tomonori Nakai, Hiroaki Imataka. An in Vitro Reconstitution System Defines the Defective Step in the Biogenesis of Mutated β-Actin Proteins. ACS synthetic biology. 2021. 10. 11. 3158-3166

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MISC (7)：

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Lectures and oral presentations (12)：

C9orf72-GGGGCC リピートで生じるRepeat Associated Non-AUG(RAN)翻訳のヒト翻訳因子による再構成型翻訳系を用いた分子機構解析
(第18 回無細胞生命科学研究会 2024)
CAG リピート由来フレームシフトの試験管内解析
(第18 回無細胞生命科学研究会 2024)
ER連動型ヒト因子由来・再構成型翻訳システムの開発
(第18 回無細胞生命科学研究会 2024)
Elucidation of the effects of polyamines on CAG repeat-derived translation
(2023)
Development of an ER-coupled in vitro translation system reconstituted with human factors
(2023)

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Professional career (1)：

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