SHIMAZU Tadahiro

シマヅタダヒロ | SHIMAZU Tadahiro

Research field (3)： Metabolism and endocrinology , Molecular biology , Genomics

Research keywords (5)： acetylation , mitochondria , metabolism , methylation , epigenetics

Research theme for competitive and other funds (4)：

2020 - 2023 Role of protein histidine methylation
2016 - 2018 Role of Histidine methylation by METTL9
2015 - 2018 Development of the chemical detectors and inhibitors for protein methylation toward chemical epigenomics
2004 - 2006 動物細胞における新規アセチル化およびメチル化蛋白質の同定とその機能解析

Papers (31)：

Tadahiro Shimazu, Rei Yoshimoto, Kaoru Kotoshiba, Takehiro Suzuki, Shogo Matoba, Michiko Hirose, Mai Akakabe, Yoshihiro Sohtome, Mikiko Sodeoka, Atsuo Ogura, et al. Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism. Genes & Development. 2023
Qi Fang, Yusuke Kimura, Tadahiro Shimazu, Takehiro Suzuki, Ayumi Yamada, Naoshi Dohmae, Shintaro Iwasaki, Yoichi Shinkai. Mammalian HEMK1 methylates glutamine residue of the GGQ motif of mitochondrial release factors. Scientific reports. 2022. 12. 1. 4104-4104
Yoshihiro Sohtome, Tadahiro Shimazu, Yoichi Shinkai, Mikiko Sodeoka. Propargylic Se-adenosyl-l-selenomethionine: A Chemical Tool for Methylome Analysis. Accounts of chemical research. 2021. 54. 20. 3818-3827
Eriko Matsuura-Suzuki, Tadahiro Shimazu, Mari Takahashi, Kaoru Kotoshiba, Takehiro Suzuki, Kazuhiro Kashiwagi, Yoshihiro Sohtome, Mai Akakabe, Mikiko Sodeoka, Naoshi Dohmae, et al. METTL18-mediated histidine methylation on RPL3 modulates translation elongation for proteostasis maintenance. 2021
Erna Davydova, Tadahiro Shimazu, Maren Kirstin Schuhmacher, Magnus E Jakobsson, Hanneke L D M Willemen, Tongri Liu, Anders Moen, Angela Y Y Ho, Jędrzej Małecki, Lisa Schroer, et al. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Nature communications. 2021. 12. 1. 891-891

ｍore...

MISC (5)：

島津忠広, 五月女宜裕, 袖岡幹子, 眞貝洋一. メチル化酵素の新規標的分子の網羅的解析. 実験医学別冊エピジェネティクス実験スタンダード: もう悩まない!ゲノム機能制御の読み解き方. 2017. 379-388
Masanari Takahashi, Yasushi Takemoto, Tadahiro Shimazu, Hisashi Kawasaki, Makoto Tachibana, Yoichi Shinkai, Motoki Takagi, Kazuo Shin-Ya, Yasuhiro Igarashi, Akihiro Ito, et al. Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines (vol 65, pg 263, 2012). JOURNAL OF ANTIBIOTICS. 2014. 67. 10. 737-738
T. Shimazu, Y. Komatsu, K. I. Nakayama, H. Fukazawa, S. Horinouchi, M. Yoshida. Regulation of SV40 large T-antigen stability by reversible acetylation (vol 25, pg 7391, 2006). ONCOGENE. 2014. 33. 29. 3886-3886
Jing-Yi Huang, Matthew D. Hirschey, Tadahiro Shimazu, Linh Ho, Eric Verdin. Mitochondrial sirtuins. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. 2010. 1804. 8. 1645-1651
島津忠広, 堀之内末治, 吉田稔. 阻害剤が明らかにした蛋白質リジンアセチル化の多様性. 蛋白質核酸酵素 10月号増刊. 2007. 52. 13. 1751-1757

Professional career (1)：

Work history (1)：

Association Membership(s) (2)：

The Japanese Society for Epigenetics , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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