Ikeda Yoshiki

イケダヨシキ | Ikeda Yoshiki

Affiliation and department：

Research field (1)： Pharmaceuticals - chemistry and drug development

Research theme for competitive and other funds (6)：

2021 - 2026 Development of next-generation-antibodies based on shark VNAR platform
2022 - 2024 Novel GBM therapeutic drug development targeting on Integrin
2020 - 2023 Talin1によるインテグリン活性化を介した神経膠(芽)腫悪性化メカニズムの解明
2021 - 2022 未利用水産資源を有効活用する次世代抗体作製技術のフィージビリティスタディ
2020 - 2022 Discovery and Development of Drugs for Glioblastoma based on Integrin inhibition

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Papers (15)：

Koh Takeuchi, Yoshiki Ikeda, Miki Senda, Ayaka Harada, Koji Okuwaki, Kaori Fukuzawa, So Nakagawa, Hong Yang Yu, Lisa Nagase, Misaki Imai, et al. The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity. Structure (London, England : 1993). 2022. 30. 6. 886-899
Yoshiki Ikeda, Akiyoshi Hirayama, Satoshi Kofuji, Yoshihisa Hirota, Ryo Kamata, Natsuki Osaka, Yuki Fujii, Mika Sasaki, Satsuki Ikeda, Eric P Smith, et al. SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides. The Journal of Biochemistry. 2021
Natsuki Osaka, Yoshihisa Hirota, Doshun Ito, Yoshiki Ikeda, Ryo Kamata, Yuki Fujii, Venkat R. Chirasani, Sharon L. Campbell, Koh Takeuchi, Toshiya Senda, et al. Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification. Frontiers in Molecular Biosciences. 2021. 8
Kentaro Kawai, Mami Tomonou, Yume Machida, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Yoshiki Ikeda, Tatsuo Kinashi, Masaaki Omote. Effect of Learning Dataset for Identification of Active Molecules: A Case Study of Integrin αIIbβ3 Inhibitors. Molecular informatics. 2021
Masanori A. Murayama, Nagisa Arimitsu, Jun Shimizu, Naruyoshi Fujiwara, Kenji Takai, Yoshiki Ikeda, Yoko Okada, Chieko Hirotsu, Erika Takada, Tomoko Suzuki, et al. Female dominance of both spatial cognitive dysfunction and neuropsychiatric symptoms in a mouse model of Alzheimer’s disease. Experimental Animals. 2021. 70. 3. 398-405

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MISC (5)：

竹内恒, 池田幸樹, 千田美紀, 原田彩佳, 奥脇弘次, 福澤薫, 中川草, 長瀬里沙, 今井美咲, 廣田佳久, et al. Molecular evolution of PI5P4Kβ that underlies the GTP resilience. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
Yoshiki Ikeda, Tatsuo Kinashi. Drug discovery strategy for transmembrane proteins from the perspective of integrin drug discovery. SAR News. 2020. 39. 17-23
小藤智史, 小藤智史, 池田幸樹, WOLFE Kara, RANDHAWA Jaskirat, 河口理紗, 河口理紗, 島田裕子, 小藤香織, 佐々木美加, et al. がん特異的な代謝 7.GTP代謝. 実験医学. 2017. 35. 10. 1633-1641
S. Kofuji, M. Warren, K. Sumita, A. Ramkissoon, M. Sasaki, N. Majd, H. Yoshino, K. Kofuji, K. Okumura, Y. Ikeda, et al. GTP metabolic switch promotes malignant growth of brain tumors. MOLECULAR BIOLOGY OF THE CELL. 2015. 26
IKEDA YOSHIKI, OKADA YASUHIRO, SATO ASAKO, KANAI TAMOTSU, TOMITA MASARU, ATOMI HARUYUKI, KANAI AKIO. ArchaeaにおけるRNA binding proteinであるFAU-1はRibosomal RNAのprocessingに関わる新規RNaseである. 日本分子生物学会年会プログラム・要旨集(Web). 2014. 37th. 1P-0285 (WEB ONLY)

Patents (2)：

Books (2)：

Lectures and oral presentations (10)：

Toward establishment for in silico-oriented Science
(2021)
インテグリン関連疾患治療薬開発に向けた薬剤スクリーニング法の開発
(スクリーニング学研究会 2019)
アカデミア創薬・インテグリン創薬コンソーシアム事業から学ぶアカデミア創薬研究の流れ
(スクリーニング学研究会 2019)
The physiological role of GTP sensing activity of PI5P4Kβ and its evolutional aspects
(The Molecular Biology Society of Japan 2018 2018)
Structure-based screening to identify inhibitor against GTP-sensor kinase, PI5P4Kβ, for cancer therapy.
(UC symposia conference 2018 2018)

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Professional career (1)：

Awards (1)：

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