Rchr
J-GLOBAL ID:201801002197958511   Update date: Nov. 10, 2024

Akihiro Sugai

スガイ アキヒロ | Akihiro Sugai
Affiliation and department:
Research field  (1): Neurology
Research theme for competitive and other funds  (5):
  • 2024 - 2027 Deciphering Synaptic Pruning and Neurodegeneration from Human Cryptic Exons
  • 2022 - 2025 脳小血管線維化促進細胞の同定による脳小血管老化の解明
  • 2020 - 2023 選択的スプライシングの操作により天然変性領域を制御するALS治療戦略の検証
  • 2017 - 2020 Therapeutic strategy for ALS with nucleic acid technology focusing on the vulnerability of TDP-43 autoregulation
  • 2015 - 2017 Modeling ALS with TDP-43 proteinopathy
Papers (34):
  • Akihiro Sugai, Takuma Yamagishi, Shingo Koide, Osamu Onodera. The Multifaceted Regulation of TDP-43 Condensates at the Intersection of Physiology and Pathology: Implications for Neurodegenerative Diseases. Phase Separation in Living Cells. 2023. 253-270
  • 小出 眞悟, 須貝 章弘, 小野寺 理. 【いま新薬で加速する 神経変性疾患研究 異常タンパク質の構造、凝集のしくみから根本治療の真の標的に迫る】(第1章)タンパク質構造と病態 ALS病態のカギを握る液-液相分離. 実験医学. 2023. 41. 12. 1883-1889
  • 小出 眞悟, 須貝 章弘, 小野寺 理. 【ALS-どこまでわかり,どこまで治るか】原因と発症機序 TDP-43. Clinical Neuroscience. 2023. 41. 3. 338-341
  • Yuka Koike, Akihiro Sugai, Norikazu Hara, Junko Ito, Akio Yokoseki, Tomohiko Ishihara, Takuma Yamagishi, Shintaro Tsuboguchi, Mari Tada, Takeshi Ikeuchi, et al. Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex. Communications Biology. 2021. 4. 1. 1107-1107
  • Taisuke Kato, Ri-Ichiroh Manabe, Hironaka Igarashi, Fuyuki Kametani, Sachiko Hirokawa, Yumi Sekine, Natsumi Fujita, Satoshi Saito, Yusuke Kawashima, Yuya Hatano, et al. Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model. The Journal of clinical investigation. 2021. 131. 22
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MISC (31):
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Professional career (1):
  • 博士(医学) (新潟大学)
Work history (6):
  • 2023/04 - 現在 新潟大学医歯学総合病院 脳神経内科
  • 2019/10 - 2023/03 Niigata University Brain Research Institute Center for Bioresources Brain Science Branch Department of Molecular Neuroscience
  • 2019/04 - 2019/09 Niigata University Medical and Dental Hospital
  • 2017/11 - 2019/03 Niigata University University Medical and Dental Hospital Advanced Disaster Medical and Emergency Critical Care Center Specially Appointed Assistant Professor
  • 2016/06/01 - 2017/10/31 Niigata University University Medical and Dental Hospital Neurology Specially Appointed Assistant Professor
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Awards (1):
  • 2019/12 - 第3回せりか基金
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