Yosuke Shikama

Research field (1)： Oral medicine (pathology)

Research theme for competitive and other funds (6)：

2021 - 2024 Common molecular mechanisms underlying age- and autoimmune-related disturbance of salivary secretion
2019 - 2023 Inflammatory transformation of myofibers via neutrophil fusion - Elucidation of the onset mechanism of chronic myalgia-
2018 - 2021 Potential role of interleukin-29 in oral mucosal defense against viruses
2016 - 2018 Possible involvement of palmitate in the pathogenesis of primary Sjogren's Syndrome
2014 - 2015 飽和脂肪酸がシェーグレン症候群の病態増悪に関与する可能性:モデルマウスによる解析

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Papers (48)：

Masae Furukawa, Hirobumi Tada, Resmi Raju, Jingshu Wang, Haruna Yokoi, Mitsuyoshi Yamada, Yosuke Shikama, Takashi Saito, Takaomi C Saido, Kenji Matsushita. Effects of tooth loss on behavioral and psychological symptoms of dementia in app knock-in mice. Journal of oral biosciences. 2024
Haruna Yokoi, Jingshu Wang, Yoriko Ikuyo, Mitsuyoshi Yamada, Yosuke Shikama, Masae Furukawa, Kenji Matsushita. Long-term sorbitol consumption affects the hippocampus and alters cognitive function in aged mice. Genes to cells : devoted to molecular & cellular mechanisms. 2024
Masae Furukawa, Haruna Yokoi, Jingshu Wang, Yoriko Ikuyo, Hirobumi Tada, Mitsuyoshi Yamada, Yosuke Shikama, Kenji Matsushita. Premature gray hair development in the interbrow region owing to the loss of maxillary first molars in young mice. Genes to cells : devoted to molecular & cellular mechanisms. 2024
Haruna Yokoi, Masae Furukawa, Jingshu Wang, Yu Aoki, Resmi Raju, Yoriko Ikuyo, Mitsuyoshi Yamada, Yosuke Shikama, Kenji Matsushita. Erythritol Can Inhibit the Expression of Senescence Molecules in Mouse Gingival Tissues and Human Gingival Fibroblasts. Nutrients. 2023. 15. 18
Masae Furukawa, Hirobumi Tada, Resmi Raju, Jingshu Wang, Haruna Yokoi, Yoriko Ikuyo, Mitsuyoshi Yamada, Yosuke Shikama, Kenji Matsushita. Long-Term Capsaicin Administration Ameliorates the Dysfunction and Astrogliosis of the Brain in Aged Mice with Missing Maxillary Molars. Nutrients. 2023. 15. 11. 2471-2471

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MISC (28)：

中本真理子, 森更紗, 首藤恵泉, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, et al. 日本人勤労者の大豆イソフラボン摂取行動に寄与する食事関連因子の探索的検討-Soy and Isoflavone Intake and Lifestyle and Health Awareness in Japanese Workers-第24回研究報告会記録. 大豆たん白質研究 / 不二たん白質研究振興財団 [編]. 2022. 24. 42. 154-161
古川匡恵, 田淵拓也, 山田三良, 四釜洋介, 松下健二. 歯周組織の細胞老化について若齢および老齢マウスと培養ヒト歯肉線維芽細胞における検討. 日本歯周病学会会誌. 2021. 63. 秋季特別. 119-119
中本真理子, 森更紗, 大河内章充, 首藤恵泉, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 四釜洋介, 板東由記子, et al. The Association between Intake of Soy and Isoflavones and Hyperuricemia and Renal Function in Japanese Male Workers: a Longitudinal Study. 大豆たん白質研究. 2021. 23
黒澤実愛, 古川匡恵, 松下健二, 四釜洋介. Cellular senescence in salivary gland epithelial cells may induce the accumulation of senescence-associated T cells (SA-Ts) in murine submandibular glands. Journal of Oral Biosciences Supplement (Web). 2020. 2020
Yasuo Endo, Hiromi Funayama, Kouji Yamaguchi, Yuko Monma, Zhiqian Yu, Xue Deng, Takefumi Oizumi, Yosuke Shikama, Yukinori Tanaka, Satoshi Okada, et al. [Basic Studies on the Mechanism, Prevention, and Treatment of Osteonecrosis of the Jaw Induced by Bisphosphonates]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2020. 140. 1. 63-79

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Education (2)：

2006 - 2010 Tohoku University Graduate School of Dentistry
2000 - 2006 Tohoku University Faculty of Dentistry Department of Dentistry

Professional career (1)：

歯学博士 (東北大学)

Work history (7)：

2023/04 - 現在東北大学大学院歯学研究科長寿口腔科学講座客員教授
2021/04 - 現在国立長寿医療研究センター口腔疾患研究部副部長
2010 - 現在東北大学歯学研究科歯内歯周治療学分野非常勤講師
2016/10 - 2021/03 国立長寿医療研究センター口腔疾患研究部口腔感染制御研究室室長
2016/04 - 2016/09 徳島大学病院糖尿病対策センター特任講師

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Awards (6)：

2022/11 - 第27回日本エンドトキシン・自然免疫研究会最優秀賞
2020/10 - ドライアイ研究会 2020年ドライアイリサーチアワード
2017/09 - Finalist in the 2017 Research Forum Poster Competition. 103rd Annual Meeting of The American Academy of Periodontology. Boston, MA September 2017
2017/07 - 第29回歯科基礎医学会学会奨励賞
2014/01 - The excellent poster award. The 5th International Symposium for Interface Oral Health Science. Sendai, Japan, January 2014

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