Nakadai Tomoyoshi

ナカダイトモヨシ | Nakadai Tomoyoshi

Affiliation and department：
Job title：博士研究員

Research field (1)： Genetics

Research keywords (5)： Cancer biology , Epigenetics , Biochemistry , Gene expression regulation , Transcription regulation

Research theme for competitive and other funds (9)：

2022 - 2025 転移性乳癌で生じる多様な変異体タンパク質の機能異常性の網羅的解析と病的意義の解明
2020 - 2023 Stratification of breast cancer based on single-cell analysis
2019 - 2022 Comprehensive analysis of mutant ERa found in cancers to reveal their aberrant functions
2006 - 2007 新規コアクチベーターによる転写過程の包括的調節機構の解析
2004 - 2006 組み換え蛋白質によるRNAポリメラーゼII再構成と各サブユニットの新規機能の探索

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Papers (38)：

Calvin Jon A Leonen, Miho Shimada, Caroline E Weller, Tomoyoshi Nakadai, Peter L Hsu, Elizabeth L Tyson, Arpit Mishra, Patrick MM Shelton, Martin Sadilek, R David Hawkins, et al. Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts. eLife. 2021. 10
Kenichi Miyata, Yoshinori Imai, Satoshi Hori, Mika Nishio, Tze Mun Loo, Ryo Okada, Liying Yang, Tomoyoshi Nakadai, Reo Maruyama, Risa Fujii, et al. Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer. Proceedings of the National Academy of Sciences of the United States of America. 2021. 118. 35
Jean-Pierre Etchegaray, Lei Zhong, Catherine Li, Telmo Henriques, Eileen Ablondi, Tomoyoshi Nakadai, Capucine Van Rechem, Christina Ferrer, Kenneth N Ross, Jee-Eun Choi, et al. The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. Molecular cell. 2019. 75. 4. 683-699
Miho Shimada, Wei-Yi Chen, Tomoyoshi Nakadai, Takashi Onikubo, Mohamed Guermah, Daniela Rhodes, Robert G Roeder. Gene-Specific H1 Eviction through a Transcriptional Activator→p300→NAP1→H1 Pathway. Molecular cell. 2019. 74. 2. 268-283
Lorna A Farrelly, Robert E Thompson, Shuai Zhao, Ashley E Lepack, Yang Lyu, Natarajan V Bhanu, Baichao Zhang, Yong-Hwee E Loh, Aarthi Ramakrishnan, Krishna C Vadodaria, et al. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. 2019. 567. 7749. 535-539

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Books (5)：

分子生物学: ゲノミクスとプロテオミクス
東京化学同人 2018
改訂版遺伝子工学実験ノート上
羊土社 2009
転写因子・転写制御キーワードブック
羊土社 2006
分子生物学イラストレイテッド
羊土社 2002
遺伝子工学実験ノート上
羊土社 2001

Lectures and oral presentations (5)：

Two transcription activation mechanisms by orphan nuclear receptor ERRthrough cofactor PGC-1a and basal transcription factor TFIIH
(2017)
Biochemical analysis to elucidate multiple step transcription activation mechanism by orphan nuclear receptor ERR
(2017)
Biochemical analysis to elucidate multiple step transcription activation mechanism by orphan nuclear receptor ERR
(2017)
オルファン核内受容体ERRによる転写コファクターPGC-1αと基本転写因子TFIIHを介した多段階転写活性化機構の発見
(米国日本人医師会ニューヨークライフサイエンスフォーラム (NY州立大学) 2017)
Transcription activation mechanism by orphan nuclear receptor ERRa through cofactors
(2015)

Education (4)：

1999 - 2003 Chiba University
1998 - 1999 アメリカ合衆国ミネソタ大学分子生物学神経科学研究生
1996 - 1998 Chiba University
1992 - 1996 Chiba University Faculty of Science Department of Biology

Work history (4)：

2018/02 - 現在 Japanese Foundation for Cancer Research
2013/05 - 2018/01 アメリカ合衆国ロックフェラー大学生化学分子生物学研究室リサーチアソシエイト
2008/05 - 2013/01 アメリカ合衆国ロックフェラー大学生化学分子生物学研究室ポストドクター
2003/04 - 2008/04 Saitama Medical University Faculty of Medicine

Awards (1)：

2016/04 - Best poster award Molecular mechanism of transcription activation by orphan nuclear receptor ERR thorough cofactors

Association Membership(s) (5)：

Cold Spring Harbor Meeting , Keystone symposia , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE CANCER ASSOCIATION , 日本エピジェネティクス研究会

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