Rchr
J-GLOBAL ID:201801002417181521   Update date: Jun. 19, 2024

Sawako Goto

ゴトウ サワコ | Sawako Goto
Affiliation and department:
Research field  (1): Nephrology
Research keywords  (6): 糖尿病性腎臓病 ,  慢性腎臓病 ,  急性腎障害 ,  質量分析 ,  メガリン ,  近位尿細管
Research theme for competitive and other funds  (3):
  • 2022 - 2025 メガリンと腎毒性リガンドの結合様式とメガリン拮抗薬の薬理機序の立体構造学的解析
  • 2021 - 2025 メガリンの構造と機能の精密解析に基づく腎臓病の病態解明と診断・治療の新たな創薬
  • 2019 - 2022 Investigation of the role of megalin in the renal renin-angiotensin system
Papers (43):
  • Sawako Goto, Akihisa Tsutsumi, Yongchan Lee, Michihiro Hosojima, Hideyuki Kabasawa, Koichi Komochi, Satoru Nagatoishi, Kazuya Takemoto, Kouhei Tsumoto, Tomohiro Nishizawa, et al. Cryo-EM structures elucidate the multiligand receptor nature of megalin. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 22. e2318859121
  • Sawako Goto, Michihiro Hosojima, Hideyuki Kabasawa, Kaho Arai, Kazuya Takemoto, Hiroyuki Aoki, Koichi Komochi, Ryota Kobayashi, Nanako Sugita, Taeko Endo, et al. Megalin-related mechanism of hemolysis-induced acute kidney injury and the therapeutic strategy. The Journal of pathology. 2024
  • Marcel Bokhove, Takashi Kawamura, Hideo Okumura, Sawako Goto, Yoshiaki Kawano, Stefan Werner, Franziska Jarczowski, Victor Klimyuk, Akihiko Saito, Takashi Kumasaka. The structure of the rat vitamin B12 transporter TC and its complex with glutathionylcobalamin. The Journal of biological chemistry. 2024. 300. 5. 107289-107289
  • Masafumi Tsuchida, Shin Goto, Hirofumi Watanabe, Sawako Goto, Hiroki Yamaguchi, Ichiei Narita. Defective C3d caused by <i>C3</i> p.<scp>W1034R</scp> in inherited atypical hemolytic uremic syndrome. Molecular Genetics & Genomic Medicine. 2023
  • Sawako Goto, Yutaka Yoshida, Michihiro Hosojima, Shoji Kuwahara, Hideyuki Kabasawa, Hiroyuki Aoki, Tomomichi Iida, Ryuhei Sawada, Daisuke Ugamura, Yuta Yoshizawa, et al. Megalin is involved in angiotensinogen-induced, angiotensin II-mediated ERK1/2 signaling to activate Na+-H+ exchanger 3 in proximal tubules. Journal of hypertension. 2023
more...
MISC (22):
Patents (5):
  • 横紋筋融解により誘発される腎障害の抑制
  • 溶血反応により誘発される腎障害の抑制
  • 造影剤腎症のコバラミンを用いた新規予防法の開発
  • 腎障害の抑制におけるシラスタチンの利用
  • 質量分析計による腎臓,血液,尿のアンジオテンシンペプチドの定量法の開発
Books (1):
  • 体重管理が困難な透析患者への支援[総論]I 透析療法における体重管理の諸問題(1)血液透析療法における体重管理
    臨床透析 2014
Lectures and oral presentations  (10):
  • The role of Megalin in the Regulation of Renal RAS: Investigation Using LC/MS-Based Multiple-Reaction Monitoring Quantification of Angiotensin Peptides
    (Annual Meeting of American Society of Nephrology 2018)
  • Investigation of the role of megalin in the renal RAS by LC/MS-based multiple-reaction monitoring quantification of angiotensin peptides
    (第61回日本腎臓学会学術総会 2018)
  • LC/MSを用いた選択的反応モニタリングによる臓器・体液の内因性アンジオテンシンペプチド定量法
    (第42回日本医用マススペクトル学会年会 2017)
  • Stewart-Fencl法を利用した血液透析導入時における酸塩基平衡異常の検
    (第58回日本腎臓学会学術総会 2015)
  • 血液透析施行中の運動による循環動態および循環血液量変化の観察
    (第43回埼玉透析医学会学術 集会・総会 2014)
more...
Education (3):
  • 2014 - 2019 Niigata University Graduate School of Medical and Dental Sciences Course of Biological Functions and Medical Control
  • 2005 - 2011 Niigata University Faculty of Medicine School of Medicine
  • 2002 - 2005 山形県立山形東高等学校
Professional career (1):
  • 博士(医学) (新潟大学)
Work history (6):
  • 2024/04 - 現在 東北大学大学院医歯学系研究科 腎臓内科学分野/腎臓・高血圧内科 助教
  • 2019/04 - 2024/03 Niigata University Graduate School of Medical and Dental Sciences
  • 2015/04 - 2019/03 Niigata University Graduate School of Medical and Dental Sciences
  • 2014/04 - 2015/03 Jichi Medical University
  • 2013/04 - 2014/03 日本海総合病院 循環器内科・腎臓膠原病内科 後期研修医
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Association Membership(s) (5):
JAPANESE SOCIETY FOR BIOMEDICAL MASS SPECTROMETRY ,  JAPAN COLLEGE OF RHEUMATOLOGY ,  THE JAPANESE SOCIETY FOR DIALYSIS THERAPY ,  JAPANESE SOCIETY OF NEPHROLOGY ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE
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