Research theme for competitive and other funds (14)：
2018 - 2028 Multi-omics association of cardiovascular diseases for next-generation precision medicine
2023 - 2026 Single-cell multi-omics stratification in cardiovascular disease
2023 - 2026 Elucidation of the molecular mechanism of the onset and pathogenesis of arrhythmogenic right ventricular cardiomyopathy by two-hit theory using the genomic bank with cell lines
2022 - 2025 Novel diagnostic and prognostic factors in chronic thromboembolic pulmonary hypertension based on genomic information.
2022 - 2025 Integrated understanding of cardiac system structure and its control through other complex approaches
2022 - 2025 Multilayered and Integrative Evidence Generation Research to Prevent Atrial Fibrillation and Serious Complications
2021 - 2024 Elucidation of genetic factors that define myocardial vulnerability as a basis for the development of heart failure
2021 - 2024 Pathophysiology and Precision Medicine by Multi-Omics Analysis in Intractable Cardiovascular Diseases
2021 - 2024 GENESIS-J-DCM: A national consortium for investigating genetic diversity in Japanese patients with dilated cardiomyopathy
2022 - 2023 Study to evaluate the usefulness and necessity of genomic and omics research in cardiovascular disease
2020 - 2023 Research on disease onset prediction and prevention programs for the realization of personalized medicine for cardiovascular diseases
2021 - 2022 Pathophysiology and precision medicine of atrial fibrillation by whole genome analysis and tissue omics analysis
2016 - 2019 The innovative drug development that targeted molecules associated with coronary artery diseases and its functional analysis
Show all
Papers (74)：
Xiaoxi Liu, Satoshi Koyama, Kohei Tomizuka, Sadaaki Takata, Yuki Ishikawa, Shuji Ito, Shunichi Kosugi, Kunihiko Suzuki, Keiko Hikino, Masaru Koido, et al. Decoding triancestral origins, archaic introgression, and natural selection in the Japanese population by whole-genome sequencing. Science advances. 2024. 10. 16. eadi8419
Shuji Ito, Xiaoxi Liu, Yuki Ishikawa, David D Conti, Nao Otomo, Zsofia Kote-Jarai, Hiroyuki Suetsugu, Rosalind A Eeles, Yoshinao Koike, Keiko Hikino, et al. Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects. Nature communications. 2023. 14. 1. 4863-4863
Johanna L Smith, Catherine Tcheandjieu, Ozan Dikilitas, Kruthika Lyer, Kazuo Miyazawa, Austin Hilliard, Julie Lynch, Jerome I Rotter, Yii-Der Ida Chen, Wayne Huey-Herng Sheu, et al. A Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization. medRxiv : the preprint server for health sciences. 2023
Min Young Jang, Parth N Patel, Alexandre C Pereira, Jon A L Willcox, Alireza Haghighi, Angela C Tai, Kaoru Ito, Sarah U Morton, Joshua M Gorham, David M McKean, et al. Contribution of Previously Unrecognized RNA Splice-Altering Variants to Congenital Heart Disease. Circulation. Genomic and precision medicine. 2023. 16. 3. e003924-231
Shohei Kojima, Satoshi Koyama, Mirei Ka, Yuka Saito, Erica H Parrish, Mikiko Endo, Sadaaki Takata, Misaki Mizukoshi, Keiko Hikino, Atsushi Takeda, et al. Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk. Nature genetics. 2023. 55. 6. 939-951
Kaoru Ito. The World of Super "A new health indicator called X-ray age - easily calculated from a single radiograph.". Journal of society of automotive engineers of Japan. 2023. 77. 11. 132-134
Kaoru Ito. Genetic risk of coronary artery disease. Nippon Rinsho. 2023. 81. 1241. 101-108
Kaoru Ito. What is the Polygenic Risk Score (PRS) to "visualize" genetic risk?. ournal of Clinical and Experimental Medicine(IGAKU NO AYUMI). 2022. 283. 14. 1241-1247
Nobuyuki Enzan, Kaoru Ito. Past, Present, and Future Perspectives on Genomic and Omics Research in Cardiovascular Disease. Heart. 2022. 54. 10. 1086-1093
Methods and systems for determining the risk of arrhythmia or arrhythmia-related disorders
Radiographic age estimation learning device, radiographic age estimation device, image age estimation learning device, image age estimation device, radiographic system, evaluation device, radiographic age estimation learning method, radiographic age estimation method and program
Genetic risk score to predict the onset and prognosis of ischemic heart disease
Books (1)：
内科学 第12版
朝倉書店 2022
Lectures and oral presentations (53)：
Scientific Committee Planning Symposium 5 "Prospects for Genomic Medicine in Vascular Disease" "Clinical Implementation and Prospects for Polygenic Risk Scores for Ischemic Heart Disease"
(The 64th Annual Meeting of Japanese College of Angiology 2023)
Symposium 16 Genetics of Complex Diseases “Genomic analysis and polygenic score application in cardiovascular diseases”
(Human Genetics Asia 2023 2023)
Innovations in Heart Failure and Cardiovascular Disease Based on Genomic and Omics Associations
(The 27th Annual Scientific Meeting of the Japanese Heart Failure Society 2023)
Educational Lecture 6 "Cardiovascular Genomics Research and Clinical Applications"
(The 71st Annual Scientifc Session of the Japanese College of Cardiology 2023)
Future Vision Committee Planning [Young Members' Session] 3 / Building a New Cardiology through Collaboration of Clinical and Basic Research "Genome Analysis of Cardiovascular Multifactorial Diseases and the Road to Realization of Precision Medicine"
(The 71st Annual Scientifc Session of the Japanese College of Cardiology 2023)
2019/07 - 現在 RIKEN Center For Integrative Medicial Sciences Laboratory for Cardiovascular Genomics and Informatics Team Leader
2019/04 - 現在 Graduate School of Medicine, Yokohama City University Department of Genetics
2018/04 - 2019/06 RIKEN Center for Integrative Medical Sciences Laboratory for Cardiovascular Diseases Team Leader
2017/04 - 2019/03 School of Medicine, Yokohama City University Department of Genetics Part-time lecturer, Graduate school of Medicine
2016/04 - 2018/03 RIKEN Center for Integrative Medical Sciences Laboratory for Cardiovascular Diseases Team Leader
2011/05 - 2016/03 Broad Institute Medical Population Genetics Research Associate
2011/04 - 2016/03 Harvard Medical School Department of Genetics Postdoctoral Fellow
Show all
Committee career (4)：
2023/03 - 現在 The Japanese Circulation Society Genetic Testing Guidelines Subcommittee
2022/07 - 現在 Japan Circulation Society Member of Sub-Working Group (SWG) for Strengthening Clinical and Basic Research, Five-Year Plan to Conquer Cardiovascular Disease
2022/06 - 現在 Japan Circulation Society Scientific Committee Collaborator
2023/10 - The Japan Heart Failure Society The 11th Academic Award Innovations in Heart Failure and Cardiovascular Disease Based on Genomic and Omics Associations
2021/02 - Springer Nature Communications Biology Reviewer of the Month
2021 - RIKEN RIKEN-BAIHOU AWARD A Multinational Study to Elaborate Risk Factors for Coronary Artery Disease
2021 - Japanese Circulation Society Circulation journal. Best reviewers award for 2021
2017 - International Heart Journal Best reviewer Award 2017
2009 - Japan Heart Foundation Japanese Heart Foundation Research Encouragement Award
2006 - Japanese Heart Failure Society Young Investigator Award
Show all
Association Membership(s) (9)：
Japanese Society of Human Genetics
, JAPANESE HEART FAILURE SOCIETY
, American Heart Association
, American Society of Human Genetics
, The Japanese Circulation Society
, THE JAPANESE SOCIETY OF INTERNAL MEDICINE
, Japanese College of Cardiology
, Japanese Society of Bioinfomatics
, European Society of Cardiology
