Rchr
J-GLOBAL ID：201801002571248671
Update date: Oct. 30, 2024
Masatake Fujimura
フジムラ マサタケ | Masatake Fujimura
Affiliation and department：
Job title：
Director
Homepage URL (1)：
http://nimd.env.go.jp/kakubu/kiso/fujimura.html
Research field (3)：
Pharmaceuticals - health and biochemistry
, Environmental effects of chemicals
, Environmental effects of radiation
Research keywords (3)：
Methylmercury
, Neuropharmacology
, Neurotoxicology
Research theme for competitive and other funds (11)：
- 2022 - 2025 Development of biomarkers that can objectively determine differences in individual susceptibility to methylmercury poisoning
- 2019 - 2022 Experimental research on regenerative treatment of axon and muscle fiber for nerve and muscle dysfunction by methylmercury
- 2018 - Fundamental research on effect of fructo-oligosaccharide and wheat bran on tissue mercury concentration under low level methylmercury exposure from fish eating.
- 2017 - A new development toward mechanism elucidation on subsequent generation of methylmercury toxicity and sex difference: significance of glucocorticoid variation
- 2014 - 2016 Research on inciting factor of neurological symptoms following low dose methylmercury exposure in fetal period.
- 2012 - 2016 Molecular mechanism on sex immature imprinting and childcare collapse induced by environmental pollutant
- 2013 - 2015 Research on variation of mRNA surveillance by environmental stress and its effect for pathological condition.
- 2012 - 2013 Examination on vascular endothelial growth factor as a new molecular target for methylmercury poisoning
- 2011 - 2013 Experimental research on selective neuronal damage by methylmercury using microdissection method
- 2008 - 2010 Experimental research on effect of Rho kinase inhibitors against neurological impairment by environmental toxins
- 2005 - Santéenvironnement et santé-travail" program
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Papers (81)：
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Ryohei Miki, Ryosuke Nomura, Yuta Iijima, Sho Kubota, Nobumasa Takasugi, Takao Iwawaki, Masatake Fujimura, Takashi Uehara. Therapeutic potential of 4-phenylbutyric acid against methylmercury-induced neuronal cell death in mice. Archives of Toxicology. 2024
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Hisaka Kurita, Haruka Masuda, Ayu Okuda, Suzuna Go, Kazuki Ohuchi, Hiroki Yoshioka, Masatake Fujimura, Isao Hozumi, Masatoshi Inden. Epigenetic alternations in the SYP and DLG4 genes due to low-level methylmercury exposure during neuronal differentiation in vitro. Journal of applied toxicology : JAT. 2024
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Yuta Iijima, Ryohei Miki, Nobumasa Takasugi, Masatake Fujimura, Takashi Uehara. Characterization of pathological changes in the olfactory system of mice exposed to methylmercury. Archives of Toxicology. 2024
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Masatake Fujimura, Takamitsu Unoki. BDNF specifically expressed in hippocampal neurons is involved in methylmercury neurotoxicity resistance. Environmental Toxicology. 2024. 39. 5. 3149-3159
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Yuta Iijima, Ryohei Miki, Masatake Fujimura, Seiichi Oyadomari, Takashi Uehara. Methylmercury-induced brain neuronal death in CHOP-knockout mice. The Journal of Toxicological Sciences. 2024. 49. 2. 55-60
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MISC (12)：
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鵜木隆光, 秋山雅博, 熊谷嘉人, 藤村成剛. メチル水銀によるタンパク質結合性超硫黄分子の変動. Fundamental Toxicological Sciences (Web). 2022. 9. Supplement
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鵜木隆光, 秋山雅博, 新開泰弘, 熊谷嘉人, 藤村成剛. Protective role of reactive sulfur species under electrophilic stress. Journal of Toxicological Sciences. 2020. 45. Supplement
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鵜木隆光, 秋山雅博, 熊谷嘉人, 藤村成剛. 活性イオウ分子の脳内分布とメチル水銀感受性の連関. Fundamental Toxicological Sciences (Web). 2020. 7. Supplement
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鵜木隆光, 秋山雅博, 熊谷嘉人, 藤村成剛. メチル水銀の細胞傷害特異性に対する活性イオウ分子の影響. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
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T. Takahashi, M. Fujimura, F. Usuki, M. Koyama, M. Kanazawa, M. Nishizawa, T. Shimohata. BLOOD-BRAIN BARRIER DYSFUNCTION CAUSED BY VASCULAR ENDOTHELIAL GROWTH FACTOR UPREGULATION IN RAT MODELS OF SUBACUTE METHYLMERCURY INTOXICATION. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2016. 36. 268-268
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Patents (6)：
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Condensed thiophene compounds and medicinal use thereof.
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Takanashi S. Aromatic amid compounds.
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Dihydropyrazolopyridine compounds and medicinal use thereof.
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Fused thiophene compounds and medicinal use thereof.
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Condensed thiophene compounds and pharmaceutical use thereof.
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Lectures and oral presentations (140)：
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培養大脳皮質神経細胞と海馬神経細胞を用いたメチル水銀毒性と遺伝子発現プロファイルの比較検討
(令和3年度メチル水銀研究ミーティング 2022)
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高濃度メチル水銀曝露によるマウス中枢小胞体ストレス惹起
(令和3年度メチル水銀研究ミーティング 2022)
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メチル水銀毒性センサーの開発
(令和3年度メチル水銀研究ミーティング 2022)
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BDNF specifically expressed in hippocampal neurons is involved in its resistance to methylmercury neurotoxicity.
(61st Society of Toxicology 2022)
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メチル水銀曝露における細胞内サルフェン硫黄の遷移
(第49回日本毒性学会(2022) 2022)
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Education (3)：
- - 2001 Kyushu University Doctor of Pharmacology
- 1987 - 1989 Kagoshima University Master of Science
- 1983 - 1987 Kagoshima University Bachelor of Science
Professional career (1)：
Work history (10)：
- 2023/04 - 現在 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences Affiliate Professor
- 2022/04 - 現在 National Institute for Minamata Disease
- 2018/04 - 現在 National Institute for Minamata Disease
- 2018/04 - 現在 National Institute for Minamata Disease Department of Basic Medical Science Director for Research General Coordination/Director
- 2013/04 - 2018/03 National Institute for Minamata Disease Toxicologic Pathology Section Chief
- 2005/04 - 2013/03 National Institute for Minamata Disease Pathology Section Chief
- 2008/04 - 2009/09 Bordeaux University in France Visiting professor
- 2004/09 - 2005/03 National Institute for Minamata Disease Physiology Section Chief
- 1989/04 - 2004/08 Mitsubishi Tanabe pharma corporation Senior researcher
- 2001/04 - 2002/03 YRING in United Kingdom, present PsyRING Senior researcher
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Committee career (5)：
- 2019/10 - 現在 The Japanese Society of Toxicology, Metal Bioscience group Standing Executive
- 2019 - 現在 日本毒性学会 評議員
- 2018 - 現在 国際水銀会議 運営委員
- 2018 - 現在 日本毒性学会, 生体金属部会 幹事
- 2014 - 現在 Fundamental Toxicological Sciences 編集委員
Association Membership(s) (2)：
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE SOCIETY OF TOXICOLOGY
