Ohashi Akihiro

Affiliation and department：
Job title： Division Head
Homepage URL (1)： https://www.ncc.go.jp/jp/epoc/division/translational_genomics/kashiwa/members/20180914101020.html

Research field (1)： Tumor biology

Research theme for competitive and other funds (4)：

2022 - 2025 癌細胞における染色体不安定性が引き起こす細胞内ストレス反応
2020 - 2024 A novel germline mutation in the non-coding region of BRCA2 is associated with hereditary breast cancer
2020 - 2023 新規CDC7キナーゼ阻害剤TAK-931の併用療法開発に向けた橋渡し研究
2019 - 2021 癌細胞における染色体不安定性が引き起こす細胞内ストレス反応

Papers (56)：

Kosuke Tanaka, Yasuki Adachi, Miyuki Yoshiya, Takuya Owari, Tomoko Yamamori-Morita, Akihiro Ohashi, Susumu Kobayashi, Shohei Koyama, Hiroyoshi Nishikawa. Abstract 5265: Targeting mtDNA dynamics enhances immunogenicity and sensitizes KRAS mutant cancers to PD-1 blockade. Cancer Research. 2024. 84. 6_Supplement. 5265-5265
Pinyi Lu, Ryo Kamata, Michael R. Weil, Naomi Ohashi, Akihiro Ohashi, Eric A. Stahlberg. Abstract 4945: Computational modeling-based discovery of novel anticancer drug candidates targeting centromere-associated protein E. Cancer Research. 2024. 84. 6_Supplement. 4945-4945
Ryo Kamata, Hitoshi Saito, Yumi Hakozaki, Yukie Kashima, Gaku Yamamoto, Tomoko Yamamori Morita, Pinyi Lu, Akihiro Ohashi. Abstract 411: PI3K-AKT-mTOR signaling pathways play important roles in chromosomal instability-induced innate immune response in cancer cells. Cancer Research. 2024. 84. 6_Supplement. 411-411
Gaku Yamamoto, Kosuke Tanaka, Ryo Kamata, Takehiro Nakao, Shunta Mori, Jie Liu, Susumu S. Kobayashi, Akihiro Ohashi. Abstract 1938: WEE1 inhibition prevents and overcomes resistance to KRAS inhibitors in lung cancer by enhancing MCL1-mediated apoptosis. Cancer Research. 2024. 84. 6_Supplement. 1938-1938
Ryo Kamata, Toyohiro Yamauchi, Yuta Sakae, Ross Breckenridge, Martin Treder, Akihiro Ohashi. Abstract B148: Novel low-atomic cluster Ag5 induced oxidative stress and antiproliferation in Esophageal Squamous Cell Carcinoma Cells. Molecular Cancer Therapeutics. 2023. 22. 12_Supplement. B148-B148

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MISC (10)：

Hiroki Yamashita, Jason Guoqiang Zhang, Chiaki Mashima, Ryo Kamata, Tomoko Yamamori, Izuma Nakayama, Akihito Kawazoe, Kohei Shitara, Tomonori Yano, Qunli Xu, et al. Abstract 5075: Transcriptomic landscape of tumor microenvironment in gastric cancer in treatment with different types of cancer drugs. Cancer Research. 2024. 84. 6_Supplement. 5075-5075
Gaku Yamamoto, Kosuke Tanaka, Ryo Kamata, Shunta Mori, Jie Liu, Toyohiro Yamauchi, Yuta Sakae, Akihiro Ohashi, Susumu S. Kobayashi. Abstract 5739: Targeting WEE1 to improve the therapy of KRAS G12C mutant non-small cell lung cancer. Cancer Research. 2023. 83. 7_Supplement. 5739-5739
山盛智子[森田], 大橋紹宏, 波江野洋, 牧野嶋秀樹, 鈴木絢子, 小林進. がん細胞内の代謝変化が関与する染色体不安定性ストレスへの適応機構. 日本癌学会総会記事. 2020. 79回. PJ6-8
N Minami, R Ihara, H Takayama, A Ohashi, A Aizawa, H Imai. Nuclear localization of Oogenesin, an oocyte- and embryo-specific novel gene in mouse preimplantation embryo. BIOLOGY OF REPRODUCTION. 2003. 68. 261-262
A Ohashi, N Minami, H Imai. Phosphorylation of cyclin A2 is in accordance with the activation of CDC2 klnase. BIOLOGY OF REPRODUCTION. 2002. 66. 103-104

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Patents (3)：

Method of predicting effects of cdc7 inhibitor
Therapeutic agent for cance
Cancer treatment methods based on tp53 mutation status and hypermutation status

Education (2)：

1997 - 2001 Kyoto University Gradulate School of Agriculture Applied Bioscience
1993 - 1997 Kyoto University Department of Agriculture

Work history (8)：

2018/09 - 現在 National Cancer Center Exploratory Oncology Research & Clinical Trial Center Division Head
2017/05 - 2018/08 Takeda Pharmaceuticals Internationals Inc. Oncology Drug Disovery Unit Senior Scientist
2016/01 - 2017/04 Takeda Pharmaceutical Company Ltd. Oncology Drug Discovery Unit Molecular Pharmacology Group Head
2014/04 - 2015/12 Takeda Pharmaceutical Company Ltd. Oncology Drug Disovery Unit Molecular Function Subgourp Head
2007/10 - 2014/03 Takeda Pharmaceutical Company Ltd. Oncology Drug Discovery Unit Principal Research Scientist

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Association Membership(s) (3)：

日本分子生物学会 , THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER , THE JAPANESE CANCER ASSOCIATION

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