Rchr
J-GLOBAL ID：201801002870614080
Update date: Aug. 29, 2024
HIRATA YOSHIYUKI
ヒラタ ヨシユキ | HIRATA YOSHIYUKI
Affiliation and department：
Research field (1)：
Pharmaceuticals - chemistry and drug development
Research keywords (5)：
natural products
, medicinal chemistry
, protein-protein interactions
, HDAC 1/2-selective inhibitors
, Histone Deacetylase
Research theme for competitive and other funds (3)：
- 2022 - 2025 新可溶性発現技術を用いたケモエンザイマティック反応によるアミド化合物合成法の開発
- 2019 - 2022 Development of chemoenzymatic synthesis of amino acids and derivatives based on enzyme engineering
- 2016 - 2018 Novel therapy for neurological disorders by protein-protein interaction inhibitor
Papers (22)：
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Kota Sato, Yuto Sasaki, Michiko Ohno-Oishi, Kuniyuki Kano, Junken Aoki, Kosuke Ohsawa, Takayuki Doi, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Chihiro Kawano, et al. New Dihydropyridine Derivative Attenuates NF-κB Activation via Suppression of Calcium Influx in a Mouse BV-2 Microglial Cell Line. The Tohoku journal of experimental medicine. 2024. 263. 2. 151-160
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Hiroshi Tawarayama, Yoshiyuki Hirata, Keiko Uchida, Noriko Himori, Shinichi Uesato, Toru Nakazawa. Isozyme-specific histone deacetylase 1/2 inhibitor K560 attenuates oxidative stress-induced retinal cell death. Neuroscience Letters. 2023. 793. 136978-136978
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Haomin Yan, Tsutomu Sasaki, Hideaki Kanki, Yoshiyuki Hirata, Kumiko Nishiyama, Sunao Hisada, Shigenobu Matsumura, Yasuo Nagaoka, Takaaki Sumiyoshi, Seiichi Nagano, et al. MDMX elevation by a novel Mdmx-p53 interaction inhibitor mitigates neuronal damage after ischemic stroke. Scientific reports. 2022. 12. 1. 21110-21110
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Yoshiyuki Hirata, Hinata Nishino, Tsutomu Sasaki, Yasuo Nagaoka, Shinichi Uesato, Masahiko Taniguchi. Sirtuin inhibition and neurite outgrowth effect as new biological activities for Areca catechu nut alkaloids. Phytomedicine Plus. 2022. 2. 3. 100294-100294
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Hinata Nishino, Yoshiyuki Hirata, Yasuo Nagaoka, Shinichi Uesato. [Isoform Selectivity of HDAC Inhibitors Has a Significant Effect on PD-L1 Expression in the Triple-negative Cancer Cell Line MDA-MB-231]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2022. 142. 4. 431-437
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MISC (43)：
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石田斉, 平田佳之. ルテニウムポリピリジル錯体の抗がん活性. 関西大学先端科学技術シンポジウム講演集. 2024. 28th
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平田佳之, 宇藤春香, 波方志保里, 谷口雅彦. Search for molecules related to neurodegenerative diseases that interact with aporphine alkaloids derived from Ziziphus jujuba Miller var. spinosa Hu ex H. F. Chou. 日本薬学会年会要旨集(Web). 2024. 144th
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石田斉, 平田佳之. 先端科学技術推進機構医工薬連携研究センター研究費 抗がん活性を目指した新規ルテニウム錯体の開発. 技苑. 2024. 158
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平田佳之, 上里新一, 谷口雅彦. Picrasidine Lのp53/DRAM経路を介したオートファジー誘導メカニズムについて. 日本生薬学会年会講演要旨集. 2023. 69th
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平田佳之, 宇藤春香, 谷口雅彦. Chemical constituents of seeds from Zizyphus jujuba Mill. var. spinosa Hu ex H.F.Chou. 日本薬学会年会要旨集(Web). 2023. 143rd
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Professional career (1)：
Work history (5)：
- 2024/04 - 現在 大阪医科薬科大学 薬学部 講師
- 2021/04 - 現在 大阪医科薬科大学 薬学部 助教
- 2014/04 - 2021/03 大阪薬科大学 薬学部 助教
- 2009/04 - 2014/03 Kansai university Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University
- 2005/04 - 2009/03 Kansai university
Association Membership(s) (5)：
日本生物工学会
, 日本化学会
, 日本ケミカルバイオロジー学会
, 日本生薬学会
, 日本薬学会
